Results 131 to 140 of about 2,025,517 (288)
The Yeshiva University Observer ; April 2024
One of two, independent undergraduate student-run newspapers of Yeshiva University's Stern College for Women, Yeshiva College, and Sy Syms School of BusinessYeshiva University’s Stern College in 1958, The YU Observer is the independent newspaper of ...
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
The Yeshiva University Observer ; March 2024
One of two, independent undergraduate student-run newspapers of Yeshiva University's Stern College for Women, Yeshiva College, and Sy Syms School of BusinessYeshiva University’s Stern College in 1958, The YU Observer is the independent newspaper of ...
core
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
MachinesMotor temperature prediction is critical for ensuring the reliability and safe operation of high-power-density electric drives. Since direct measurement of internal temperatures, especially rotor and magnet temperatures, is often impractical, virtual ...
Yaofei Han +6 more
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Disentangling Brillouin’s Negentropy Law of Information and Landauer’s Law on Data Erasure
EntropyThe link between information and energy introduces the observer and their knowledge into the understanding of a fundamental quantity in physics. Two approaches compete to account for this link—Brillouin’s negentropy law of information and Landauer’s law ...
Didier Lairez
doaj +1 more source
This work establishes a minimal, physically grounded definition of an observer—finite, local, interaction-driven, and relational—and shows that from these conditions alone, the core structures of physics necessarily follow. Quantum mechanics (Hilbert space, linearity, Born rule, no-cloning, uncertainty), thermodynamics (the second law, Landauer’s ...
openaire +5 more sources