Results 221 to 230 of about 83,343,124 (294)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intra- and Interobserver Reliability of the CT-Based Glenoid Arc-Angle Method Using Injured-Side and Contralateral Reference Circles: A Diagnostic Reliability Study. [PDF]

Diagnostics (Basel)
Strasser S, Pallua JD, Aschaber A, Kralinger F, Dammerer D, Krappinger D, Arora R, Hengg C.   +7 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

High-fidelity but hypometric spatial localization of afterimages across saccades. [PDF]

Sci Adv
Schweitzer R, Seel T, Raisch J, Rolfs M.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Observer-based control of linear complementarity systems. [PDF]

Camlibel, M.K., Heemels, W.P.M.H., Brogliato, B., Schumacher, J.M.   +3 more
core  

Evaluation of the Diagnostic Performance and Validation of an AI-Assisted Fluorescence Imaging Device for Fecal Egg Counts Against the Manual McMaster Reference Method in Kiko Male Goats. [PDF]

Animals (Basel)
Mirzaei A, Rahmani Shahraki A, Maunsell FP, Diehl BN.   +3 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Bio-Inspired Event-Based Visual Servoing for Ground Robots. [PDF]

IEEE Control Syst Lett
Mordad M, Behzad K, Biswas D, Cowan NJ, Siami M.   +4 more
europepmc   +1 more source