Results 181 to 190 of about 17,165 (264)

High‐Content SRS Imaging Unveils Altered Cholesterol Metabolism in Ovarian Cancers Under CAR‐T Treatment

open access: yesAdvanced Science, EarlyView.
High‐content Stimulated Raman Scattering (SRS) Imaging reveals that ovarian cancer cells surviving Chimeric Antigen Receptor (CAR) ‐T cell challenge exhibit increased cholesterol esterification. Pharmacological inhibition of this pathway with Avasimibe significantly enhances CAR‐T induced killing of ovarian cancer cells by reducing cancer cell ...
Chinmayee V. Prabhu Dessai   +8 more
wiley   +1 more source

Thermally Induced Creep and Viscoelastic Behavior of Copper Micropillar Arrays

open access: yesAdvanced Science, EarlyView.
Copper micropillar arrays are fabricated by electrodeposition within through‐glass‐via, and their thermally induced time‐dependent deformation is quantified. Nanoindentation creep, EBSD, and TEM reveal a heat‐treatment‐driven transition between grain‐boundary‐mediated deformation and dislocation‐dominated creep, while Kelvin modeling captures ...
Miao Wang   +14 more
wiley   +1 more source

Addressing Oxygen Embrittlement in Additively Manufactured Titanium via Cu‐Mediated Interstitial Site Engineering

open access: yesAdvanced Science, EarlyView.
A novel “Cu‐mediated interstitial site engineering” strategy is introduced to thermodynamically stabilize hexagonal oxygen (hex‐O) configurations in oxygen‐containing titanium alloys. The hex‐O configuration activates multiple slip systems and enhances dislocation pinning via long‐range repulsion.
Xiaobin Lin   +14 more
wiley   +1 more source

Feline‐Inspired Robot Enabled by Combustion‐Driven Actuators for Agile Motion and High‐Payload Obstacle Traversal

open access: yesAdvanced Science, EarlyView.
Inspired by nature's competitive maneuvers, this study introduces a combustion‐driven soft actuator that powers a multi‐modal “Jump‐and‐Fly Catbot” (JFC). With millisecond response, high‐force output (over 70 times its weight) and precise control (error within 5%), the robot can jump, fly, hover, and escape from challenging environments, achieving ...
Hongkuan Ma   +4 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu   +7 more
wiley   +1 more source

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