Results 101 to 110 of about 1,380,158 (388)

Therapeutic alternatives with CPAP in obstructive sleep apnea [PDF]

, 2019
Obstructive Sleep Apnea (OSA), characterized by airflow cessation (apnea) or reduction (hypopnea) due to repeated pharyngeal obstructions during sleep, causes frequent disruption of sleep and hypoxic events. The condition is linked to many adverse health
Aluas, Maria, Bordea, Roxana I, Budin, Corina E, Ciumarnean, Lorena, Cozma, Angela, Gergely, Bianca D, Maierean, Anca, Man, Milena, Rajnovean, Ruxandra   +8 more
core   +3 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Low lung function in Bipolar Disorder and Schizophrenia: a hidden risk

Frontiers in Physiology
Introduction: People with serious mental illness (SMI), such as schizophrenia and bipolar disorder, have a higher risk of premature morbidity and mortality.
Cristina Ruiz-Rull, Cristina Ruiz-Rull, María José Jaén-Moreno, María José Jaén-Moreno, Gloria Isabel del Pozo, Gloria Isabel del Pozo, Cristina Gómez, Cristina Gómez, Francisco Javier Montiel, Francisco Javier Montiel, Montserrat Alcántara, Montserrat Alcántara, Laura Carrión, Laura Carrión, Geli Marie Chauca, Geli Marie Chauca, Nuria Feu, Ipek Guler, Fernando Rico-Villademoros, Cristina Camacho-Rodríguez, Luis Gutierrez-Rojas, Luis Gutierrez-Rojas, David Mannino, Fernando Sarramea, Fernando Sarramea, Fernando Sarramea, Fernando Sarramea   +26 more
doaj   +1 more source

INTESTINAL OBSTRUCTION [PDF]

AJN, American Journal of Nursing, 1977
L H, Stahlgren, N W, Morris
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Pathophysiology of obstructive sleep apnoea syndrome: a review

Sultan Qaboos University Medical Journal, 2000
Sleep apnoea syndrome is a common disorder and a major health hazard that affects many body systems. It is particularly associated with increased cardiovascular and cerebrovascular morbidity and mortality. Among its other manifestations include increased
Al Riyami B, Al Rawas O, Hassan MO
doaj  

Preoperative decompression for left-sided obstructive colorectal cancer: a comparative study between a stent and a decompression tube

Videosurgery and Other Miniinvasive Techniques
Introduction: Stents and decompression tubes (DTs) are both commonly utilized for preoperative decompression in patients with left-sided obstructive colorectal cancer (OCRC).
Xin-Chun Guo, Qiang Lu, Yu-Fei Fu, Xin Lu   +3 more
doaj   +1 more source

Prognostic Factors Related to Sleep Quality in Patients With Obstructive Sleep Apnea After Positive Airway Pressure Therapy [PDF]

Journal of Rhinology
Background and Objectives This study aimed to evaluate the factors that influence deep sleep restoration in patients with obstructive sleep apnea (OSA) following positive airway pressure (PAP) therapy.
Dong Heun Park, Hangseok Choi, Kukjin Nam, Seung Hoon Lee, Min Young Seo   +4 more
doaj   +1 more source

The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases [PDF]

, 2013
[no ...
Abdala, Ana P, Burchell, Amy, Engleman, Zoar J, Fudim, Marat, Gourine, Alexander V, Hart, Emma C J, Lobo, Mel, Marina, Nepthali, McBryde, Fiona D, Nightingale, Angus, Patel, Nik, Paton, Julian F R, Ratcliffe, Laura E K, Sobotka, Paul A   +13 more
core   +2 more sources