Results 121 to 130 of about 1,380,158 (388)

The Prevalence of the Alpha-1 Antitrypsin Deficiency in Patients with Chronic Obstructive Pulmonary Disease

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2011
Background and Objectives: Alpha 1-antitrypsin deficiency (AATD) is one of the genetic risk factors in the patients suffering from chronic obstructive pulmonary disease (COPD).
E Nadi, M Hajilui, S Abdoli, Z Basiri
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

European Respiratory Journal, 2017
C. Vogelmeier, G. Criner, F. Martinez, A. Anzueto, P. Barnes, J. Bourbeau, B. Celli, Rongchang Chen, M. Decramer, L. Fabbri, P. Frith, David M.G. Halpin, M. V. Lopez Varela, M. Nishimura, N. Roche, R. Rodríguez-Roisín, D. Sin, Dave Singh, R. Stockley, J. Vestbo, J. Wedzicha, A. Agustí   +21 more
semanticscholar   +2 more sources

Comparative assessment of changes in pharyngeal airway space in cases of obstructive sleep apnoea with a customized mandibular repositioning appliance - a clinical study [PDF]

Sleep Science
Objectives: The present study aims at evaluating the effects of a customized mandibular repositioning appliance on the pharyngeal airway, nocturnal sleep patterns, daytime discomfort and occlusal changes in established cases of adult obstructive sleep ...
Rezeen Aziz, Sanju Somaiah, Anmol S Kalha, Goutham Reddy, Sunil Muddaiah, Balakrishna Shetty   +5 more
doaj   +1 more source

Simple predictors of obstructive sleep apnea in obese patients

, 2022
Hakan Şilek, Fatma Ferda Kartufan, Arzu Güntürk, Ayşegül Görmez, Ferda Fatma, Yunus Kartufan, Mah Emre, Ltfi, S Jehan, F Zizi, S Pandi-Perumal, S Wall, Auguste Myers, A, V Kapur, D Auckley, S Chowdhuri, D Kuhlmann, R Mehra, K Ramar, E Paschetta, P Belci, A Alisi, D Liccardo, R Cutrera, G Musso, A Arsoy, B Sertoullarndan, S Ekin, M zgke, M Bulut, M Huyut, C Bilgin, U Erkorkmaz, M Ucar, N Akin, A Nalbant, A Annakkaya, M Kapoor, G Greenough, D Sommermeyer, D Zou, D Eder, J Hedner, J Ficker, W Randerath, M Bosi, G Milioli, S Riccardi, A Melpignano, A Vaudano, P Cortelli, D Pitson, N Chhina, S Knijn, M Van Herwaaden, J Stradling, B Izci, S Ardic, H Firat, A Sahin, M Altinors, I Karacan, G Pillar, A Bar, A Shlitner, R Schnall, J Shefy, P Lavie, D Singh, C Das, M Baruah, D Adler, P Bridevaux, O Contal, M Georges, E Dupuis-Lozeron, E Claudel, A Delessert, F Espa, A Rossetti, G Lavigne, M Tafti, R Heinzer, P Halsz, M Terzano, L Parrino, R Bdizs, A Soylu, E Levent, N Sarman, S Yurtlu, S Alparslan, A Sayg, ztrk, S Tuna, H Alki, M Has, H Balcolu, H Trkkahraman   +99 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Swallowing disorders in patients with obstructive sleep apnea: a critical literature review [PDF]

Sleep Science
Patients with obstructive sleep apnea (OSA) may show signs and symptoms of altered swallowing function since repetitive episodes of OSA may cause hypoxia (decreased oxygen concentration in the blood) and hypercapnia (increased carbon dioxide ...
Gabriele Ramos de Luccas, Giédre Berretin-Felix   +1 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Wind Instrument Training and Sound-Based Interventions for Sleep Quality and Obstructive Sleep Apnoea: A Narrative Synthesis

Noise and Health
Background: Tolerability issues with continuous positive airway pressure (CPAP) therapy for obstructive sleep apnoea (OSA) have spurred interest in nonpharmacological alternatives like sound-based interventions (wind instrument training, singing and ...
Yi Ding, KaiLi Jiang
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source