Results 81 to 90 of about 4,753,165 (342)

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Diagnostic value of pyruvate kinase isoenzyme type M2 in colon cancer proven with colonoscopy

Advanced Biomedical Research, 2020
Background: Colonoscopy is the gold standard for colon cancer screening; it is also associated with a high cost and complication. Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed M2 pyruvate kinase ...
Hamid Kalantari, Mahsa Khodadoostan, Majid Yaran, Abdolrasoul Tavakoli   +3 more
doaj   +1 more source

Detection of Colorectal Serrated Polyps by Stool DNA Testing: Comparison with Fecal Immunochemical Testing for Occult Blood (FIT)

PLoS ONE, 2014
Objectives Precursors to 1/3 of colorectal cancer (CRC), serrated polyps have been under-detected by screening due to their inconspicuous, non-hemorrhagic, and proximal nature.
R. Heigh, Tracy C Yab, W. Taylor, F. T. Hussain, T. Smyrk, D. Mahoney, M. Domanico, B. Berger, G. Lidgard, D. Ahlquist   +9 more
semanticscholar   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Association of fecal occult blood tests results with colonoscopic findings in a general hospital and validation of the screening test

Journal of Coloproctology, 2019
Globally, colorectal cancer is the third leading cause of cancer death among men and the second among women, corresponding to about 10% of all cancers. The Brazilian Ministry of Health and National Cancer Institute recommend the screening of colorectal ...
Ana Flávia Saraceni, Rodrigo Azevedo, Clarissa Maria Gomes Almeida, Antônio Carlos Baraviera, Desiderio Roberto Kiss, Maristela Gomes Almeida   +5 more
doaj   +1 more source

Occult Hepatitis B virus infection in previously screened, blood donors in Ile-Ife, Nigeria: implications for blood transfusion and stem cell transplantation

Virology Journal, 2016
Hepatitis B virus (HBV) transmission through blood transfusion is reduced by screening for hepatitis B surface antigen (HBsAg). However this method cannot detect the presence of occult hepatitis B virus infection.
A. Olotu, A. Oyelese, L. Salawu, R. Audu, A. Okwuraiwe, A. Aboderin   +5 more
semanticscholar   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Alternative hepatitis B virus DNA confirmatory algorithm identified occult hepatitis B virus infection in Chinese blood donors with non-discriminatory nucleic acid testing [PDF]

, 2020
International audienceBackground: Multiplex viral nucleic acid testing (NAT) and a discriminatory testing algorithm have been used to detect viral infections in blood donors.
Zang, Liang, Li, Tingting, Guo, Xiaohan, Laperche, Syria, Candotti, Daniel, Deng, Xuelian   +5 more
core   +1 more source

Evaluation of the incidence of occult bacteremia among children with fever of unknown origin

Brazilian Journal of Infectious Diseases
We reviewed the incidence of occult bacteremia, to identify the most frequent etiological agents of bacteremias in otherwise healthy children from one month to 10 years old, who had fever of unknown origin attended at the emergency ward of an urban ...
Eitan Naaman Berezin, Marco Antonio Iazzetti   +1 more
doaj   +1 more source

A Comparative Study of Three Fecal Occult Blood Tests in Upper Gastrointestinal Bleeding

Kaohsiung Journal of Medical Sciences, 2006
The purpose of this study was to evaluate the performance characteristics of three fecal occult blood tests (FOBTs): the chemical o-toluidine test, the immunochemical OC-Hemodia test, and the immunochromatographic Quick Chaser Occult Blood (QCOB) test ...
Chien-Hua Chiang, Jen-Eing Jeng, Wen-Ming Wang, Bing-Hong Jheng, Wan-Ting Hsu, Bai-Hsiun Chen   +5 more
doaj   +1 more source