Results 101 to 110 of about 2,220,228 (297)

A preliminary assessment of a stool-based microRNA profile for early colorectal cancer screening

Scientific Reports
Colorectal cancer screening methods are well established worldwide as a fundamental pilar in CRC management, namely through non-invasive faecal occult blood testing.
Daniela A. R. Santos, Mariana Eiras, Miguel Gonzalez-Santos, Marlene Santos, Carina Pereira, Lúcio Lara Santos, Mário Dinis-Ribeiro, Luís Lima   +7 more
doaj   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Assessment of the adherence and willingness to participate in colorectal cancer screening programs among people living in prison.

PLoS ONE
This study aimed to assess the adherence and willingness to participate in colorectal cancer screening programs in people living in prison (PLP). This survey was conducted from October 2023 and July 2024.
Giovanna Paduano, Gabriella Di Giuseppe, Mario Postiglione, Giuseppe Nese, Sabrina Morra, Maria Pavia   +5 more
doaj   +1 more source

HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors

Brazilian Journal of Medical and Biological Research, 2006
Anti-HBc positivity is a frequent cause of donation rejection at blood banks. Hepatitis B virus (HBV) infection may also occur in HBsAg-negative patients, a situation denoted occult infection. Similarly, very low levels of HBV-DNA have also been found in
J.S.F. Pereira, N.S.L. Gonçales, C. Silva, M.S.K. Lazarini, M.H.P. Pavan, V.C. Fais, F.L. Gonçales Júnior   +6 more
doaj   +1 more source

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

Advanced Science, EarlyView.
This study demonstrates the generation of human alveolar organoids from nasal cells, which, when co‐cultured with monocyte‐derived macrophages, promotes maturation of both components and forms alveolar assembloids resembling native alveoli. These alveolar organoids and assembloids offer accessible, physiologically relevant in vitro systems for ...
Man Chun Chiu, Shuxin Zhang, Cun Li, Yifei Yu, Zhixin Wan, Jingjing Huang, Wei Xue, Ying Zhou, Xiaoxin Zhu, Qiaoshuai Lan, Jiali Wu, Zijun Zhao, Yuhong Liu, Xinjie Meng, Lin Huang, Hin Chu, Honglin Chen, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +19 more
wiley   +1 more source

Faecal immunochemical test to triage patients with possible colorectal cancer symptoms: insights from the New Zealand FIT for symptomatic pilot

Frontiers in Gastroenterology
BackgroundThe New Zealand (NZ) FIT for Symptomatic Pilot (FSP) aimed to determine the feasibility of using faecal immunochemical test (FIT) as a triaging tool to assess patients presenting with symptoms suspicious for colorectal cancer (CRC).MethodsThis ...
Kai Sheng Saw, Lu-ana Ngatai, Cathy Whiteside, Susan Parry, Susan Parry, Ian Bissett   +5 more
doaj   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Analysis of bowel cancer outcomes for the national bowel cancer screening program [PDF]

, 2014
Presents a comparison of the mortality outcomes and cancer characteristics for two populations: those invited to screen in the National Bowel Cancer Screening Program (NBCSP) in 2006–2008, and those of a similar age who had not been invited to screen in ...

core  

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Prevalence of Antibodies to Hepatitis B Virus Antigens and Occult Hepatitis B Virus Infection in Blood Donors

Diyala Journal of Medicine, 2019
Background: Occult hepatitis B virus (HBV) is the presence of HBV DNA in liver tissue and/or in serum in the absence of detectable hepatitis B surface antigen (HBsAg).
Abdulrazak SH Hasan
doaj   +2 more sources