Results 41 to 50 of about 669,107 (251)

Phage Therapy for Multi-Drug Resistant Respiratory Tract Infections

Viruses, 2021
The emergence of multi-drug resistant (MDR) bacteria is recognised today as one of the greatest challenges to public health. As traditional antimicrobials are becoming ineffective and research into new antibiotics is diminishing, a number of alternative ...
Joshua J. Iszatt, Alexander N. Larcombe, Hak-Kim Chan, Stephen M. Stick, Luke W. Garratt, Anthony Kicic   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The phosphorylation of Smad3 by CaMKIIγ leads to the hepatocyte pyroptosis under perfluorooctane sulfonate exposure

Ecotoxicology and Environmental Safety
Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant and accumulated in the liver of mammals. PFOS exposure is closely associated with the development of pyroptosis. Nevertheless, the underlying mechanism is unclear. We found here that PFOS
Siyu Ren, Peiyao Liang, Ruzhen Feng, Wei Yang, Tianming Qiu, Jingyuan Zhang, Qiujuan Li, Guang Yang, Xiance Sun, Xiaofeng Yao   +9 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Occupation

, 2014
Occupation explores arguably the most potent vocal expression of public protest – music and song – through social media. Five composers, from diverse musical genres, will compose original works in parallel to acts of protest and crisis across the world ...
Tim Hopkins (4462162)
core   +1 more source

Identify customer requirements for information and library services, archive services and records management functions [PDF]

, 2008
Descripción exhaustiva de lo que se espera del personal de una biblioteca de acuerdo con sus responsabilidades funcionales y no con sus categorías contractuales.
National Occupation Standards
core   +3 more sources

Qualitative realist evaluation of an occupational therapy intervention programme (ABLE), addressing ability to perform activities of daily living among persons with chronic conditions

BMC Health Services Research
Background Chronic conditions are associated with problems related to performance of activities of daily living (ADL) stressing a need to develop and evaluate intervention programmes addressing such problems.
Vita Hagelskjær, Eva Ejlersen Wæhrens, Cecilie von Bülow, Kristina Tomra Nielsen   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Therapists’ experiences and needs with regard to providing work-focused care: a focus group study

BMC Musculoskeletal Disorders, 2021
Background Musculoskeletal disorders (MSDs) can create a temporary or permanent disability that reduce a person’s ability to work. Physiotherapists (PTs), occupational therapists (OTs) and exercise therapists (ETs) are often involved in the early ...
Wiebke Oswald, Inez Ummels, Tamara Raaijmakers, Paul Baart, J. Bart Staal, Hendrik J. Bieleman, Maria W. G. Nijhuis - van der Sanden, Yvonne F. Heerkens, Nathan Hutting   +8 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source