Results 41 to 50 of about 683,288 (260)

The VDAC1 oligomerization regulated by ATP5B leads to the NLRP3 inflammasome activation in the liver cells under PFOS exposure

Ecotoxicology and Environmental Safety
As a persistent organic pollutant, perfluorooctane sulfonate (PFOS) has a serious detrimental impact on human health. It has been suggested that PFOS is associated with liver inflammation. However, the underlying mechanisms are still unclear.
Yu Ma, Wei Yang, Peiyao Liang, Ruzhen Feng, Tianming Qiu, Jingyuan Zhang, Xiance Sun, Qiujuan Li, Guang Yang, Xiaofeng Yao   +9 more
doaj   +1 more source

Phage Therapy for Multi-Drug Resistant Respiratory Tract Infections

Viruses, 2021
The emergence of multi-drug resistant (MDR) bacteria is recognised today as one of the greatest challenges to public health. As traditional antimicrobials are becoming ineffective and research into new antibiotics is diminishing, a number of alternative ...
Joshua J. Iszatt, Alexander N. Larcombe, Hak-Kim Chan, Stephen M. Stick, Luke W. Garratt, Anthony Kicic   +5 more
doaj   +1 more source

Occupation-wise distribution of severity of secondary traumatic stress of HCPs based on their gender.

, 2021
Occupation-wise distribution of severity of secondary traumatic stress of HCPs based on their gender.
Sanjiv Rao (11495656), Prem Kumar B. N. (11495671), Sridhar K. (11495674), Manohar K. N. (11495647), Vivek Verma (575280), Sekhar Y. (11495659), Vijay Kumar K. (11495662), Amalselvam A. (11495665), Pradeep Kumar S. (11495677), Hemkumar T. R. (11495668), C. R. Satish Kumar (11495653), Neha Parashar (11495650), Judith (11495686), Shivam (11495683), Sangeeta K. (11495680), Chetan Kumar (13770)   +15 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The phosphorylation of Smad3 by CaMKIIγ leads to the hepatocyte pyroptosis under perfluorooctane sulfonate exposure

Ecotoxicology and Environmental Safety
Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant and accumulated in the liver of mammals. PFOS exposure is closely associated with the development of pyroptosis. Nevertheless, the underlying mechanism is unclear. We found here that PFOS
Siyu Ren, Peiyao Liang, Ruzhen Feng, Wei Yang, Tianming Qiu, Jingyuan Zhang, Qiujuan Li, Guang Yang, Xiance Sun, Xiaofeng Yao   +9 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Qualitative realist evaluation of an occupational therapy intervention programme (ABLE), addressing ability to perform activities of daily living among persons with chronic conditions

BMC Health Services Research
Background Chronic conditions are associated with problems related to performance of activities of daily living (ADL) stressing a need to develop and evaluate intervention programmes addressing such problems.
Vita Hagelskjær, Eva Ejlersen Wæhrens, Cecilie von Bülow, Kristina Tomra Nielsen   +3 more
doaj   +1 more source

Overview of Occupation-centered Practice

Occupation is at the core of the profession’s philosophy and occupation-centered practice is the term applied when occupation is at the core of occupational therapy practice.
Gustafsson, Louise, Molineux, Matthew
core   +1 more source

Occupation-wise distribution of mood status of HCPs based on their gender.

, 2021
Occupation-wise distribution of mood status of HCPs based on their gender.
Sanjiv Rao (11495656), Prem Kumar B. N. (11495671), Sridhar K. (11495674), Manohar K. N. (11495647), Vivek Verma (575280), Sekhar Y. (11495659), Vijay Kumar K. (11495662), Amalselvam A. (11495665), Pradeep Kumar S. (11495677), Hemkumar T. R. (11495668), C. R. Satish Kumar (11495653), Neha Parashar (11495650), Judith (11495686), Shivam (11495683), Sangeeta K. (11495680), Chetan Kumar (13770)   +15 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source