Results 41 to 50 of about 543,570 (317)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Translating and Standardizing the Persian Version Measure of Process of Care for Service Providers (MPOC-SP) in Down Syndrome [PDF]
Journal of Advanced Biomedical Sciences, 2019 Background & Objective: Down syndrome is the most common type of chromosomal abnormality that causes mental disability. In recent years, the life expectancy of these children has increased, so their special needs will also increase.
sahar sadeghi +4 more
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
, 2023 To critically review the evidence for occupation-based interventions in improving occupational performance and participation outcomes in the hospital setting. Five databases were searched from 2000–2022.
Gemma Wall (16716943) +3 more
core +1 more source
Pathogens, 2022 Helicobacter pylori (Hp) is a grade Ι carcinogen of gastric cancer (GC), and its high infection rate seriously affects human health. Cytotoxin-associated gene A (CagA) plays a key role in the carcinogenesis of Hp as one of its main virulence factors. miR-
Leilei Wu, Fei Jiang, Xiaobing Shen
doaj +1 more source
Occupational balance of Spanish occupational therapists – a challenge
Scandinavian Journal of Occupational Therapy, 2022 Occupational balance is a central aspect in occupational therapy. Awareness of occupational balance/imbalance among occupational therapists could influence the orientation of their professional interventions.To describe and compare the occupational balance status of occupational therapists working in Spain.Cross-sectional descriptive study using an ...
Loreto González-Román +5 more
openaire +3 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Occupational Prestige and Gender-Occupational Segregation
Work, Employment and Society, 2017 The purpose of this article is to determine whether there is a relationship between the proportion of women working in an occupation and the prestige assigned to that occupation. Based on a representative sample of Spanish employees from the Spanish Quality of Working Life Survey, pooled-sample data (2007–2010) are used to show that occupations with ...
García Mainar, Inmaculada +2 more
openaire +3 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source