Results 71 to 80 of about 669,107 (251)

Comment on Karthikeyan et al. Concordance between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. Toxics 2024, 12, 290

Toxics
Biodiesel exhaust toxicology is a difficult field of study, for which there is a paucity of literature, despite decades of research into the subject [...]
Katherine R. Landwehr, Alexander N. Larcombe   +1 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Strength of Occupation Indicators as a Proxy for Skill [PDF]

Labor economists have long used occupation indicators as a proxy for unobserved skills that a worker possesses. In this paper, we consider whether inter-occupational wage differentials that are unexplained by measured human capital are indeed due to ...
Levenson, Alec, Zoghi, Cindy
core  

Occupation and social sanctioning

This chapter explores discussions around non-sanctioned occupations, alongside the dark side of occupation, and the figured world of occupation. These terms emerged at a time when occupational therapists were increasingly voicing skepticism about ...
Nazabal Amores, Marcel, Sy, Michael Palapal, Benjamin-Thomas, Tanya Elizabeth, Kiepek, Niki, Valderrama Núñez, Cristian Mauricio   +4 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Functional Limit Theorems for Occupation Time Fluctuations of Branching Systems in the Cases of Large and Critical Dimensions [PDF]

Functional central limit theorem; Occupation time fluctuation; Branching particle system; Generalized Wiener process; Critical ...
Luis G. Gorostiza, A. Talarczyk, T. Bojdecki   +2 more
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Djadjiling Rockshelter: 35,000 ¹⁴C Years of Aboriginal Occupation in the Pilbara, Western Australia [PDF]

, 2010
The Pleistocene settlement of the arid zone is a prominent research theme in Australian archaeology (Hiscock 2008:45- 62; Hiscock and Wallis 2004; Marwick 2002a, 2002b; O’Connor et al. 1998; Smith 1987, 2005; Thorley 1998; Veth 1993, 1995, 2005).
Cropper, Dawn, Petchey, F., Cropper, D., Cropper, Dawn N., Law, W., Law, W. Boone, Petchey, Fiona   +6 more
core   +1 more source

Occupation-wise distribution of mood status of HCPs based on their gender.

, 2021
Occupation-wise distribution of mood status of HCPs based on their gender.
Sanjiv Rao (11495656), Prem Kumar B. N. (11495671), Sridhar K. (11495674), Manohar K. N. (11495647), Vivek Verma (575280), Sekhar Y. (11495659), Vijay Kumar K. (11495662), Amalselvam A. (11495665), Pradeep Kumar S. (11495677), Hemkumar T. R. (11495668), C. R. Satish Kumar (11495653), Neha Parashar (11495650), Judith (11495686), Shivam (11495683), Sangeeta K. (11495680), Chetan Kumar (13770)   +15 more
core   +1 more source