Results 51 to 60 of about 177,226 (317)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Parenthood Penalty in Creative Occupations: How the Covid-19 Pandemic Made Existing Inequalities Worse [PDF]
Creative occupations are well-known for inequalities and exclusions. This article focuses on one such excluded group—creative workers who are the parents of young children—to examine the impact of the pandemic on their creative careers.
Florisson, R
core +1 more source
Asian Nursing Research, 2020 Purpose: This study explored the mediating effect of career calling in the relationship between family-supportive supervisor behaviors and turnover intention among nurses.
Leigang Zhang +2 more
doaj +1 more source
Occupational Prestige and Gender-Occupational Segregation
Work, Employment and Society, 2017 The purpose of this article is to determine whether there is a relationship between the proportion of women working in an occupation and the prestige assigned to that occupation. Based on a representative sample of Spanish employees from the Spanish Quality of Working Life Survey, pooled-sample data (2007–2010) are used to show that occupations with ...
García Mainar, Inmaculada +2 more
openaire +3 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Public Health ChallengesThe current study investigates the severe environmental and public health impacts resulting from the ongoing conflict in the Gaza Strip, with a particular focus on the rapid proliferation of rodents and insects.
Zuhair Dardona, Samia Boussaa
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
, 1935 This is a chart from a study done by Dr. Egerton Elliot Hall of the unequal distribution of employment across races, particularly concerning African Americans and white Americans throughout the 1910s through the early 1930s within New Jersey. During this
core +1 more source
Cuerpos de mujer en el mundo laboral bilbaíno bajomedieval y moderno (s. XIV –XVI).
Nuevo mundo - Mundos Nuevos, 2008 Women’s labor was highly regulated in the ordinances and municipal records, and becomes a useful source to appreciate the level of feminine participation in the urban world of Bilbao in the late Middle Ages and in Early Modern period.
Ana María Rivera Medina
doaj +1 more source
Asian Development Review, 2022 This paper uses the task-content-of-occupations framework to analyze trends in employment and wages of female and male workers in the Indian labor market from 1994 to 2017.
SHRUTI SHARMA
doaj +1 more source