Results 71 to 80 of about 103,625 (269)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Leisure-time Physical Activity of Polish White-collar Workers: A Cross-sectional Study

Hong Kong Journal of Occupational Therapy, 2017
Objective/background: The aim of this study was to assess the leisure-time physical activity of Polish white-collar workers in relation to various health recommendations.
Agnieszka Nawrocka, Arkadiusz Mynarski, Jarosław Cholewa, Wiesław Garbaciak   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A changing occupation: the artisanal fishing told by those who practice (Pelotas, RS)

Revista Mundos do Trabalho, 2019
In our society, because of fast technological changes, more and more manual occupations are becoming obsolete, changing or about to disappear. This article intends to discuss these labor transformations, based on the narratives of the professional ...
Lorena Almeida Gill
doaj   +1 more source

Occupational Consciousness [PDF]

Journal of Occupational Science, 2015
Occupational consciousness refers to ongoing awareness of the dynamics of hegemony and recognition that dominant practices are sustained through what people do every day, with implications for personal and collective health. The emergence of the construct in post-apartheid South Africa signifies the country's ongoing struggle with negotiating long ...
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

الوظائف التى شغلها اﻵراميين في العراق القديم خلال العصر اﻵشوري الحديث (911–612) ق.م [PDF]

Buḥūṯ
شكلت الوظائف بكل ماتحمله الكلمة من دلالات ، جانباًﹰﹰ مهماًﹰ من الحياة اليومية في العالم كله عبر عصوره التاريخية ، ولأن مسألة الوظائف جزءاً مهماً من حياة الناس ، فمثل اﻵراميين العديد من الوظائف في العصر اﻵشوري ، ولاسيما ما قام به اﻵراميون من أعمال منها ...
عزه الحسن محمد علي كرار, عائشة محمود عبد العال ., ثناء جمعة الرشيدى .   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A construção de si pela atividade de trabalho: a socialização profissional The construction of self through work activity: the professional socialization

Cadernos de Pesquisa, 2012
A sociologia funcionalista das profissões distingue dois tipos muito diferentes de atividades de trabalho: as profissões e as ocupações (ambas no sentido que os ingleses lhes dão).
Claude Dubar
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source