Results 61 to 70 of about 464,609 (360)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Le travail et les métiers dans la télé-réalité : éléments pour une approche sociologique
Images du Travail, Travail des Images, 2018 This paper deals with representations of work, industrial relations and occupational groups in TV shows, particularly in reality TV. The first part of the text gives a quick overview of the different types of TV programs (serials, documentaries, etc ...
Marc Perrenoud
doaj +1 more source
Do Employer-Sponsored Immigrants Fare Better in Labor Markets Than Family-Sponsored Immigrants?
RSF: The Russell Sage Foundation Journal of the Social Sciences, 2020 Debates about revising U.S. legal immigration policies tend to question the economic value of immigrants sponsored by family members rather than by employers. To date, little evidence has been cited.
Julia Gelatt
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Segregação sexual do emprego em Portugal no último quarto de século – Agravamento ou abrandamento?
e-cadernos ces, 2018 This paper started off with the challenge of revisiting an article authored by Virgínia Ferreira in the book Portugal: um retrato singular [Portugal: a singular portrait] (Santos, 1993).
Lina Coelho, Virgínia Ferreira
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Occupational stress, occupational structure and occupational morbidity
International Congress Series, 2002 Abstract Occupational stress poses a substantial problem in many countries. Its rates of occurrence and its origins are therefore the subject of substantial research. Competitiveness is an increasingly prominent characteristic of many occupational environments and is considered by some to be essential for occupational advancement and achievement ...
openaire +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source