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Immunotoxic activity of ochratoxin A

Journal of Veterinary Pharmacology and Therapeutics, 2006
Ochratoxin A (OTA) is an immunosuppressant fungal compound, produced by toxigenic species ofAspergillusandPenicilliumfungi in a wide variety of climates and geographical regions. The contamination of food by this mycotoxin takes place primarily during preharvest periods. Almost all types of food can be contaminated.
Ernst Petzinger, L Al-Anati
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Effect of ochratoxin A and ochratoxin C on the monocyte and lymphocyte function

Mycotoxin Research, 2002
The effect of practically relevant mycotoxin concentrations on functions of immune cells was studied in in vitro experiments. Porcine mononuclear cells were exposed to a crudeAspergillus-ochraceus toxin containing OTA, a HPLC fraction identical with OTC derived from the crude toxin (RE2), as well as pure OTA and OTC in a concentration range from 0.46 ...
H. Rosner   +5 more
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OCHRATOXIN A IN TURKISH WINES

Journal of Food Biochemistry, 2005
In this research, 47 wine samples produced from 2001 to 2002 harvest period in four Turkish regions were analyzed for the presence of ochratoxin A (OTA). Based on the results, the OTA levels of red wines are generally higher than those of white and rose wines.
Vural, NİLÜFER   +3 more
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The fate of ochratoxin A in rats

Food and Cosmetics Toxicology, 1977
Abstract The fate of ochratoxin A was studied in rats given a single ip injection of 1 mg labelled with 14 C. Ochratoxin A reached its highest levels in serum (accounting for up to 90% of the 14 C dose), liver (4·5%) and kidney (4·4%) 30 min after the injection and then decreased gradually.
F.C. Chang, F.S. Chu
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Ochratoxins: A global perspective

Mycopathologia, 2006
Ochratoxins have been overshadowed by better-known mycotoxins, but they are gaining importance. Here we consider ochratoxins in the context of aflatoxins, which are better understood than ochratoxins on many levels. We review recent work on taxonomic distribution, contamination of commodities, biosynthesis, toxicity and regulatory aspects of ...
Paul Bayman, James L. Baker
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Synthesis of ochratoxins TA and TC, analogs of ochratoxins A and C

Experientia, 1974
Zwei Ochratoxinanaloge, Ochratoxin TA (OTA) und TC (OTC) wurden aus Ochratoxin-α chemisch synthetisiert indem Phenylalanin und sein Athylester im Molekul durch Tyrosin und Tyrosinathylester substituiert wurden. Der Huhnerembryonentest ergab, dass OTC etwas toxischer und OTA etwas weniger toxisch ist als Ochratoxin A (OA).
Ru-Dong Wei, F. S. Chu
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Ochratoxin A and Epigenetics

2017
Ochratoxin A is a thermoresistant mycotoxin produced by ubiquitous molds of Aspergillus and Penicillium genera. It contaminates foodstuffs and feedstuffs worldwide and therefore is of human and animal concern. Ochratoxin A induces oxidative stress, inflammation, and fibrosis, and is nephrotoxic, hepatotoxic, and neurotoxicin particularly in male ...
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Aspergilli as Ochratoxin Producers

Mycologia, 1972
To determine whether ochratoxin is produced by species of Aspergillus other than Asp. ochraceus, 44 strains representative of the 9 spp. composing the Asp. ochraceus group were grown on both pearled wheat and cracked corn in duplicate shaken flasks at 28°C for 5 days. Rice was a poor substrate for ochratoxin production.
M. L. Smith   +4 more
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Ochratoxin A and Related Mycotoxins

2014
Ochratoxins are toxins produced by fungal species belonging not only to Aspergilli but also to Penicillia with ochratoxin A (OTA) being the main toxin of the group followed by ochratoxin B (OTB) and ochratoxin C (OTC). These mycotoxins are formed in a variety of plant products as well as in some animal-derived products following fungal invasion.
REVERBERI, Massimo   +2 more
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Ochratoxin A in Wines

Food Reviews International, 2009
Mycotoxins are produced by fungi, commonly known as mold. Ochratoxins are a dangereous group of mycotoxins produced as secondary metabolites by several fungi of the Aspergillus or Penicillium families. Ochratoxin have been detected in foods and beverages, including grape juice and wine.
Mustafa Bayram, Ertan Anli
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