Results 71 to 80 of about 2,076 (188)
Targeting Melasma: Innovations in Pigment Deposition and Photoaging in Cosmetic Dermatology
Journal of Cosmetic Dermatology, Volume 25, Issue 1, January 2026.ABSTRACT Background Melasma is a chronic, relapsing hyperpigmentation disorder driven by complex interactions among genetic predisposition, hormonal fluctuations, UV exposure, oxidative stress, inflammation, and photoaging. Its psychosocial impact is substantial, especially among women with darker skin types, and treatment remains challenging due to ...
Ting Liao +4 more
wiley +1 more source
Patellar ligament rupture during total knee arthroplasty in an ochronotic patient
Acta Orthopaedica et Traumatologica Turcica, 2020 Ochronotic arthropathy mainly involves the spine and large joints. Along with blackening of the joint, degeneration rapidly progresses mostly in the knee, resulting in symptoms by the 4th or 5th decade.
Madan Mohan Sahoo +3 more
doaj +1 more source
Overlapping Hyperpigmented and Poikilodermatous Mycosis Fungoides
Case Reports in Dermatological Medicine, Volume 2026, Issue 1, 2026.Primary cutaneous T‐cell lymphomas (pCTCLs) are a heterogeneous group of rare clonal T‐cell disorders, among which mycosis fungoides (MF) is the most common subtype. Several clinicopathologic variants of MF have been described, including poikilodermatous and hyperpigmented forms, with occasional overlap between variants.
Joan Somja +2 more
wiley +1 more source
Ochronosis Masquerading as Osteoarthritis
Ochronosis is a rare metabolic disorder resulting from alkaptonuria due to a deficiency of homogentisate 1,2-dioxygenase, leading to accumulation and deposition of homogentisic acid in connective tissues. It commonly presents with progressive arthropathy
Manisha Sinha, Michelle Mathias
core +1 more source
Unrecognized Ochronosis - A Case Report [PDF]
, 2008 Alkaptonurija je rijedak poremećaj metabolizma koji nastaje zbog manjka oksidaze homogentizinske kiseline. Posljedica toga je nakupljanje homogentizinske kiseline u kolagenskim strukturama cijelog tijela, osobito u fibroznim i hrskavičnim tkivima.
Lucija Murgić +5 more
core +1 more source
Ochronotic Chronic Tendoachilles Rupture Management: A Case Series [PDF]
Journal of Foot and Ankle Surgery (Asia Pacific)Background: Alkaptonuria is a rare inherited genetic disorder in which there is a deficiency of the enzyme homogentisate 1,2-dioxygenase. The three characteristics of alkaptonuria are homogentisic-aciduria, ochronosis, and ochronotic arthropathy ...
Jeremy B Dorai, Issac Jebaraj
doaj +1 more source
The Use of Tranexamic Acid to Treat Melasma: A Systematic Review and Meta‐Analysis
Dermatologic Therapy, Volume 2026, Issue 1, 2026.Introduction Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits bleeding due to its effects on plasminogen conversion, approved by the FDA to treat menorrhagia and prevent bleeding in hemophilia patients undergoing dental extraction.
Nabila Scabine Pessotti +7 more
wiley +1 more source
Dermatologic Therapy, Volume 2026, Issue 1, 2026.Background Melasma treatment remains challenging with variable response to conventional lightening agents. Polyamine inhibition via ornithine decarboxylase 1 (ODC1) may offer an alternative approach, with eflornithine hydrochloride being an established ODC1 inhibitor. Objectives To compare the efficacy and safety of eflornithine hydrochloride 13% cream
Jonathan Yongwei Boey +7 more
wiley +1 more source
Exogenous Ochronosis With Ocular Involvement From Chronic Use of Teavigo.
, 2023 Exogenous ochronosis refers to accumulation of homogentisic acid metabolites in tissues, manifesting as pigmentation of affected tissues. Phenolic compounds are most commonly implicated, including hydroquinone, quinine, phenol, resorcinol, mercury, and ...
Laiton, Andrea +5 more
core +1 more source
The effects of superoxide dismutase on osteoarticular cells and structural analysis of ochronosis, in a disease model of alkaptonuria [PDF]
, 2017 Introduction: Alkaptonuria (AKU) is a rare autosomal recessive condition resulting from deficiency of homogentisate 1,2 dioxygenase, causing inability to metabolise homogentisic acid (HGA).
Taylor, Adam +2 more
core +3 more sources