Results 71 to 80 of about 2,140 (193)

Comparison of the Efficacy of Kligman's Formula Combined With 30% Topical Metformin Versus Kligman's Formula Alone in the Treatment of Melasma

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Melasma is a common hyperpigmentation disorder primarily affecting women, influenced by ultraviolet exposure, hormones, and genetics. Kligman's formula is a first‐line therapy, but emerging evidence suggests that topical metformin, an antidiabetic with antimelanogenic effects, may enhance treatment outcomes.
Fariba Iraji, Fatemeh Mokhtari, Zeinab Kassab, Sarah Seyedyousefi, Jaleh Varshosaz   +4 more
wiley   +1 more source

Hydroquinone‐Free, Tetrahexyldecyl Ascorbate Antioxidant Serum for Hyperpigmented and Photodamaged Skin to Achieve Skin Health

Journal of Cosmetic Dermatology, Volume 25, Issue 4, April 2026.
ABSTRACT Background Ascorbic acid (AA) has protective and corrective functions critical for counteracting extrinsic and intrinsic skin aging and hyperpigmentation, but it is highly unstable, making it challenging to formulate into skincare products.
McKenzie E. Maloney, May Hall, Ryan C. Kelm, Tatiana Kononov, Alisar Zahr   +4 more
wiley   +1 more source

Lumbar disc herniation in ochronosis

Indian Spine Journal, 2019
Alkaptonuria is a rare metabolic, autosomal recessive disorder caused by the deficiency of homogentisic acid oxidase and it is characterized by bluish-black discoloration of cartilages, skin (Ochronosis), degenerative changes in the articular, extra ...
Subbiah Jayakumar, Sathish Devadoss, Annamalai Devadoss   +2 more
doaj   +1 more source

Patient With A Diagnosis Of Ochronosis After Lumbar Dyscectomy: Case Report

, 2020
Ochronosis is the black discoloration of connective tissues seen with alkaptonuria, a metabolic disorder. Alkaptonuria is a rare autosomal recessive metabolic disorder caused by the lack of homogentisic acid oxidase enzyme.
Küçükyıldız, Halil Can, Eğilmez, Reyhan, Özüm, Ünal, Başpınar, Nisa, Yeldir, Neşe, KÜÇÜKYILDIZ, HALİL CAN, EĞİLMEZ, HATİCE REYHAN, BAŞPINAR, NİSA   +7 more
core   +1 more source

Long‐Term Efficacy of Arthroscopic Microfracture Combined With Autologous Collagen‐Induced Chondrogenesis for Knee Cartilage Defects: A 5‐Year Prospective Pilot Randomized Controlled Trial

Orthopaedic Surgery, Volume 18, Issue 4, Page 631-640, April 2026.
Arthroscopic microfracture combined with autologous collagen‐induced chondrogenesis provides superior long‐term cartilage regeneration and sustained clinical improvement in knee cartilage defects, as evidenced by 5‐year MRI and functional outcomes. ABSTRACT Objectives Cartilage defect of the knee joint is a common cause of knee pain and can result in ...
Shuofang Ren, Zhuosong Bai, Xin Lu, Yan Zhang, Xu Sun, Rui Tang, Bo Yang, Jun Qian, Guixing Qiu   +8 more
wiley   +1 more source

Exploring the Effectiveness, Tolerability, and Safety of the Adjunctive Use of Microneedling With Tranexamic Acid in the Treatment of Melasma

Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
ABSTRACT Background Melasma is a chronic pigment disorder associated with significant psychosocial burden. The gold standard triple combination cream is effective but limited by relapse and adverse effects. Tranexamic acid (TXA) and microneedling have independently shown promise in the treatment of melasma, and their combined use may provide enhanced ...
Sharon Dhaliwal, Navneet Dhanoa, Zaina Rashid   +2 more
wiley   +1 more source

The Harmful Trifecta of Skincare in African and Asian Populations: Triple Action Creams, Skin‐Lightening Creams, and Antiseptic Soaps

JEADV Clinical Practice, Volume 5, Issue 3, Page 991-993, September 2026.
Olufolakemi Cole‐Adeife, Monisha Madhumita, Doreen Mapunda, Daudi Mavura, Fatimata Ly   +4 more
wiley   +1 more source

Tranexamic Acid for Hyperpigmentation Disorders: A Literature Review on Efficacy and Safety in Melasma and PIH

Journal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background Hyperpigmentation disorders, including melasma and post‐inflammatory hyperpigmentation (PIH), are common dermatologic conditions associated with significant cosmetic and psychological burden. Tranexamic acid (TXA), an antifibrinolytic agent, has gained increasing attention due to its anti‐inflammatory and antimelanogenic properties.
Ahmed AlJabr, Aseel Muhana I. AlAnazi, Rakan Abdulkarim A. AlEtebi   +2 more
wiley   +1 more source

Ochronotic arthropathy of the hip with multiple joint involvement: a rare case report and literature review [PDF]

The Egyptian Orthopaedic Journal
Ochronosis is a rare inherited genetic disorder that affects tyrosine and phenylalanine metabolism. It leads to the deposition of dark pigments in connective tissues and articular cartilage, which are rich in collagen.
Plaban N. Chowdhury, Abhishek Vaish, Pankaj Baweja, Raju Vaishya   +3 more
doaj   +1 more source

Cardiac ochronosis: not so benign

, 2009
A 78-year-old patient with ochronosis has developed symptomatic aortic stenosis. He has undergone an aortic valve replacement that was highly complicated by a severe aortic calcification.
Mathonet, Perrine, Deuvaert, Frank, Wauthy, Pierre, Seghers, Valérie   +3 more
core   +1 more source