Results 51 to 60 of about 2,076 (188)

Alkaptonuria: A case report

Indian Journal of Ophthalmology, 2017
Alkaptonuria is a rare inborn error of metabolism with autosomal recessive inheritance with a mutation in homogentisate 1,2-dioxygenase. It results in accumulation of homogentisic acid in connective tissues (ochronosis). Most common ocular manifestations
Nirupama Damarla, Prathima Linga, Mallika Goyal, Sanjay Reddy Tadisina, G Satyanarayana Reddy, Hymavathi Bommisetti   +5 more
doaj   +1 more source

Exogenous ochronosis: case report and literature review Ocronose exógena: relato de caso e revisão de literatura

Anais Brasileiros de Dermatologia, 2012
Exogenous ochronosis is a rare, cosmetically disfiguring condition, resulting from the longterm use of topical hydroquinone in treatment of melasma. It manifests as gray-brown or blue-black macules in hydroquinone-exposed regions.
Viviane Maria Rocha Martins, Antônio Renê Diógenes de Sousa, Natália de Carvalho Portela, Celina Aguiar Frota Tigre, Lucidi Maria Saraiva Gonçalves, Rômulo José de Lucena Castro Filho   +5 more
doaj   +1 more source

Case Report: Ochronotic Arthropathy

Forbes Tıp Dergisi, 2021
Ochronosis is a rare metabolic disease caused by the deficiency of the homogentisic acid oxidase enzyme. It gives clinical findings related to the accumulation of homogentisic acid in soft tissues and excretion in urine. Patients with chronic arthropathy
Ülkü Dönmez, Ece Cinar, Cihat Ozturk, Simin Hepgüler   +3 more
doaj   +1 more source

Low Sunscreen Awareness and Misconceptions in Skin of Colour With Acne‐Related Post‐Inflammatory Hyperpigmentation: A Cross‐Sectional Study Highlighting the Need for Targeted Education

Australasian Journal of Dermatology, Volume 67, Issue 5, Page e299-e306, August 2026.
ABSTRACT Background/Objectives Post‐inflammatory hyperpigmentation (PIH) is a frequent sequela of acne in patients with skin of colour (SOC). While sunscreen is widely recommended for PIH prevention, little is known about real‐world sunscreen practices in this group. This study aimed to evaluate sunscreen use, barriers and factors influencing adherence
Xiaozhun Hang, Davin Sui Lim, Lisa Byrom
wiley   +1 more source

Microcore Skin Biopsies: A Novel, Micro‐Invasive Skin Biopsy Technique Yielding Full‐Thickness Histology

Skin Research and Technology, Volume 32, Issue 7, July 2026.
ABSTRACT Background Punch biopsies are considered the primary technique to obtain full‐thickness skin specimens for dermatologic diagnoses. However, limitations include scarring, sampling error, poor margin identification, and post‐sampling deformations.
Rebecca Lapides, Ga Ram Ahn, Kenechi Iwelumo, Heather Downs, Roger Sumner, Michael McCormack, William G. Austen Jr., Elisabeth Roider, Michael Wang‐Evers, Dieter Manstein   +9 more
wiley   +1 more source

Treatment of Acne‐Induced Facial Post‐Inflammatory Hyperpigmentation With a New 2‐MNG‐Containing Routine Versus a Thiamidol‐Containing Routine—A Monocentric Prospective Double‐Blind Randomized Comparative Trial

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Acne‐induced post‐inflammatory hyperpigmentation (PIHP) is a frequent condition. 2‐mercaptonicotinoyl glycine (2‐MNG) is an innovative anti‐pigmenting molecule. Aims The aim of this study is to compare the efficacy and tolerability of two routines in the treatment of PIHP: 2‐MNG‐containing serum + SPF50+/UVA sunscreen versus ...
Thierry Passeron, Guénaëlle Le Dantec, Samir Salah, Beatrice Marie, Kate Randamy, Kim T. F. C. Dhin‐Kien, Ann' Laure Demessant‐Flavigny, Andrew Alexis   +7 more
wiley   +1 more source

Cucumber‐Derived Exosome‐Like Vesicles With Melanin‐Inhibitory Activity and an Acceptable in Vitro Safety Profile

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Skin hyperpigmentation disorders affect millions worldwide, driving demand for depigmentation products. However, many conventional skin‐lightening products contain dangerous ingredients, including mercury and unregulated hydroquinone.
Che‐Yuan Hsu, Wei‐Chen Chen, Horng‐Shen Chen, Yu‐Chen Liao, Cheng‐Han Hsieh, Donald Liu, Ya‐Wen Cheng   +6 more
wiley   +1 more source

Comparison of the Efficacy of Kligman's Formula Combined With 30% Topical Metformin Versus Kligman's Formula Alone in the Treatment of Melasma

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Melasma is a common hyperpigmentation disorder primarily affecting women, influenced by ultraviolet exposure, hormones, and genetics. Kligman's formula is a first‐line therapy, but emerging evidence suggests that topical metformin, an antidiabetic with antimelanogenic effects, may enhance treatment outcomes.
Fariba Iraji, Fatemeh Mokhtari, Zeinab Kassab, Sarah Seyedyousefi, Jaleh Varshosaz   +4 more
wiley   +1 more source

Hydroquinone‐Free, Tetrahexyldecyl Ascorbate Antioxidant Serum for Hyperpigmented and Photodamaged Skin to Achieve Skin Health

Journal of Cosmetic Dermatology, Volume 25, Issue 4, April 2026.
ABSTRACT Background Ascorbic acid (AA) has protective and corrective functions critical for counteracting extrinsic and intrinsic skin aging and hyperpigmentation, but it is highly unstable, making it challenging to formulate into skincare products.
McKenzie E. Maloney, May Hall, Ryan C. Kelm, Tatiana Kononov, Alisar Zahr   +4 more
wiley   +1 more source

Long‐Term Efficacy of Arthroscopic Microfracture Combined With Autologous Collagen‐Induced Chondrogenesis for Knee Cartilage Defects: A 5‐Year Prospective Pilot Randomized Controlled Trial

Orthopaedic Surgery, Volume 18, Issue 4, Page 631-640, April 2026.
Arthroscopic microfracture combined with autologous collagen‐induced chondrogenesis provides superior long‐term cartilage regeneration and sustained clinical improvement in knee cartilage defects, as evidenced by 5‐year MRI and functional outcomes. ABSTRACT Objectives Cartilage defect of the knee joint is a common cause of knee pain and can result in ...
Shuofang Ren, Zhuosong Bai, Xin Lu, Yan Zhang, Xu Sun, Rui Tang, Bo Yang, Jun Qian, Guixing Qiu   +8 more
wiley   +1 more source