Results 51 to 60 of about 2,140 (193)

Real‐world evidence for the efficacy and tolerability of an isobutylamido‐thiazolyl‐resorcinol (Thiamidol)‐containing skincare regimen on facial hyperpigmentation and overall skin appearance: A multi‐centre study in 11 European countries

International Journal of Cosmetic Science, EarlyView.
A Thiamidol‐containing skincare regimen showed significant improvement in facial hyperpigmentation in a real‐world study across 11 European countries. The treatment led to a significant reduction in mMASI scores, enhanced overall skin condition and demonstrated high tolerability.
B. Schuster, T. Rogers, C. Vendruscolo, D. Roggenkamp, W. G. Philipp‐Dormston, F. Al‐Niaimi, S. Roussel, N. Kiss, H. Malik, D. Grozeva, K. S. Berger, C. Rauscher, L. Kolbe   +12 more
wiley   +1 more source

Ochronotic Chondropathy: A Case Report

Biomedicines, 2023
Endogenous ochronosis, also known as alkaptonuria, is a rare disease known for its bluish-black discoloration of the skin, sclerae, and pinnae, as well as urine that turns black upon standing.
Jake Littman, John Pietro, Jon Olansen, Chanika Phornphutkul, Roy K. Aaron   +4 more
doaj   +1 more source

Exogenous ochronosis

Journal of the American Academy of Dermatology, 2000
Ochronosis is an uncommon condition characterized by yellow-brown pigment deposits in the dermis. It occurs in exogenous and endogenous forms. We report a case of exogenous ochronosis in a Hispanic woman and discuss the different forms of this condition. We treated the lesions with Q-switched ruby laser.
K E, Kramer, A, Lopez, C M, Stefanato, T J, Phillips   +3 more
openaire   +2 more sources

Expert Consensus on the Management of Hyperpigmentation Disorders in India: A Modified Delphi Study by the Pigmentary Disorders Society

International Journal of Dermatology, EarlyView.
Delphi‐based expert consensus for diagnosis and management of common hyperpigmentation disorders in Indian dermatology practice, integrating evidence review, iterative voting, and consensus‐driven recommendations. ABSTRACT Hyperpigmentation disorders are prevalent in individuals with skin of color and are associated with considerable psychosocial ...
Rashmi Sarkar, Sunil Dogra, Surabhi Sinha, Keshavamurthy Vinay, Indrashis Podder, Anupam Das, Bhavesh Swarnkar, B. S. Chandrashekar, Hitaishi Mehta, Madhuri Agarwal, Muthu Sendhil Kumaran, Sonali Langar, Seemal R. Desai   +12 more
wiley   +1 more source

Exogenous Ochronosis (EO)

Autopsy and Case Reports, 2021
Ochronosis is a cutaneous disorder caused by the accumulation of phenols, either endogenously as homogentisic acid in patients with alkaptonuria (autosomal recessive disorder with deficiency of the enzyme homogentisic acid oxidase), or exogenously in ...
Amir Qorbani, Adnan Mubasher, George Peter Sarantopoulos, Scott Nelson, Maxwell Alexander Fung   +4 more
doaj  

Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria

Metabolites, 2022
Changes in the phenylalanine (PHE)/tyrosine (TYR) pathway metabolites before and during homogentisic acid (HGA)-lowering by nitisinone in the Suitability of Nitisinone in Alkaptonuria (AKU) 2 (SONIA 2) study enabled the magnitude of the flux in the ...
Lakshminarayan R. Ranganath, Andrew T. Hughes, Andrew S. Davison, Milad Khedr, Richard Imrich, Mattias Rudebeck, Birgitta Olsson, Brendan P. Norman, George Bou-Gharios, James A. Gallagher, Anna M. Milan   +10 more
doaj   +1 more source

Hyperpigmentation Disorders Management in India: A Delphi Based Expert Consensus on Epidemiology, Therapeutic Challenges, and the Evolving Role of Dermocosmetics

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Introduction Hyperpigmentation disorders impose a substantial clinical and psychosocial burden in individuals with darker skin phototypes, yet remain underrepresented in dermatological research. In India, where a large proportion of the population reports pigmentary concerns, conditions such as post‐inflammatory hyperpigmentation (PIH ...
Mukta Sachdev, Neena Khanna, Niti Khunger, Sushil Tahiliani, Anil Ganjoo, Nina Madnani, Maya Vedamurthy, Abhishek De, Rajesh Kumar, Delphine Kerob, Davinder Prasad   +10 more
wiley   +1 more source

Alkaptonuria: A case report

Indian Journal of Ophthalmology, 2017
Alkaptonuria is a rare inborn error of metabolism with autosomal recessive inheritance with a mutation in homogentisate 1,2-dioxygenase. It results in accumulation of homogentisic acid in connective tissues (ochronosis). Most common ocular manifestations
Nirupama Damarla, Prathima Linga, Mallika Goyal, Sanjay Reddy Tadisina, G Satyanarayana Reddy, Hymavathi Bommisetti   +5 more
doaj   +1 more source

Glucuronyl Glucosyloleanolate: A Safe and Potent AI‐Discovered Depigmenting Saponin

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Purpose Saponins are amphiphilic glycosides found in plants. They have long been used in traditional Asian remedies for their anti‐inflammatory, protective, and rejuvenating properties. One representative, Glucuronyl Glucosyloleanolate (GGO), was recently discovered using a combination of artificial intelligence and experimental testing as a ...
Yannick Quesnel, Michael Gold
wiley   +1 more source

Recent advances in understanding the pathogenesis of ochronosis : Najnowsze postępy w zrozumieniu patogenezy ochronozy

, 2012
Alkaptonuria (AKU) is an iconic disease caused by deficiency of the enzyme homogentisate 1,2-dioxygenase (HGD). Deficiency results in an increase in the circulating concentration of homogentisic acid (HGA), which over time is deposited as pigmented ...
Taylor, Adam, Boyde, Alan, Gallagher, James, Jarvis, Jonathan, Ranganath, Lakshminarayan   +4 more
core   +4 more sources