Results 41 to 50 of about 2,691 (207)

Ochronotic Chondropathy: A Case Report

Biomedicines, 2023
Endogenous ochronosis, also known as alkaptonuria, is a rare disease known for its bluish-black discoloration of the skin, sclerae, and pinnae, as well as urine that turns black upon standing.
Jake Littman, John Pietro, Jon Olansen, Chanika Phornphutkul, Roy K. Aaron   +4 more
doaj   +1 more source

A clinical case of ochronosis with involvement of the cardiac valvular apparatus and the musculoskeletal system in an 80-year-old patient

КардиоСоматика
BACKGROUND: Ochronosis is a rare disorder caused by an inherited defect in tyrosine metabolism, in which the biochemical degradation pathway is interrupted at the stage of homogentisic acid formation.
Amina M. Alieva, Irina V. Kovtyukh, Irina E. Baykova, Elvira A. Khachirova, Albina B. Sultangalieva, Alexander A. Melnikov, Igor G. Nikitin   +6 more
doaj   +1 more source

Exogenous ochronosis after prolonged use of topical hydroquinone (2%) in a 50-year-old Indian female

Indian Journal of Dermatology, 2012
Ochronosis is a rare disease characterized by speckled and diffuse pigmentation symmetrically over the face, neck, and photo-exposed areas. It is characterized histologically by banana-shaped ochre-colored deposits in the dermis.
Vijay Gandhi, Prashant Verma, Geetanjali Naik   +2 more
doaj   +1 more source

Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria

Metabolites, 2022
Changes in the phenylalanine (PHE)/tyrosine (TYR) pathway metabolites before and during homogentisic acid (HGA)-lowering by nitisinone in the Suitability of Nitisinone in Alkaptonuria (AKU) 2 (SONIA 2) study enabled the magnitude of the flux in the ...
Lakshminarayan R. Ranganath, Andrew T. Hughes, Andrew S. Davison, Milad Khedr, Richard Imrich, Mattias Rudebeck, Birgitta Olsson, Brendan P. Norman, George Bou-Gharios, James A. Gallagher, Anna M. Milan   +10 more
doaj   +1 more source

Phytochemical Composition of Selaginella spp. from Java Island Indonesia [PDF]

, 2012
For a long time, people in West Java, Indonesia have used Selaginella as a traditional cure for several ailments including fever, minor wounds, broken bones, women’s health disorders or postnatal bleeding.
Chikmawati, Tatik, Miftahudin,, Setyawan, Ahmad Dwi   +2 more
core   +3 more sources

Knee degenerative osteoarthritis secondary to ochronosis (case report)

Travmatologiâ i Ortopediâ Rossii, 2013
Alkaptonuria is rare disease with deficiency of homogentisate-1,2-dioxygenase enzyme, resulting in excess deposition of homogentisic acid in connective tissue. This deposition leads to ochronosis - brownish-black pigmentation of connective tissue.
V. V. Bliznyukov, A. N. Kovalenko, V. P. Rumakin   +2 more
doaj   +1 more source

Case Report: Ochronotic Arthropathy

Forbes Tıp Dergisi, 2021
Ochronosis is a rare metabolic disease caused by the deficiency of the homogentisic acid oxidase enzyme. It gives clinical findings related to the accumulation of homogentisic acid in soft tissues and excretion in urine. Patients with chronic arthropathy
Ülkü Dönmez, Ece Cinar, Cihat Ozturk, Simin Hepgüler   +3 more
doaj   +1 more source

The pathogenesis of tendinopathy. A molecular perspective [PDF]

, 2004
There are many publications that discuss the aetiology, diagnosis and treatment of the various forms of tendinopathy, but few are based on conclusive scientific evidence.
Riley, GP
core   +1 more source

Low Sunscreen Awareness and Misconceptions in Skin of Colour With Acne‐Related Post‐Inflammatory Hyperpigmentation: A Cross‐Sectional Study Highlighting the Need for Targeted Education

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Background/Objectives Post‐inflammatory hyperpigmentation (PIH) is a frequent sequela of acne in patients with skin of colour (SOC). While sunscreen is widely recommended for PIH prevention, little is known about real‐world sunscreen practices in this group. This study aimed to evaluate sunscreen use, barriers and factors influencing adherence
Xiaozhun Hang, Davin Sui Lim, Lisa Byrom
wiley   +1 more source

Okronotik Artropati: Sementsiz Total Diz Artroplastisi Uygulaması

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2010
Alkaptonuria is an autozomal recessive metabolic disease that goes with the deficiency of homo-gentisic acid oxidase. Collection of the metabolits of HGA in connective tissues results ochronosis.
Emrah Sayıt, Hakan Aslan, Erbil Aydın
doaj   +1 more source