Results 21 to 30 of about 2,076 (188)

Ochronotic Arthropathy of the Knee: A Case Report [PDF]

Orthopaedic Journal of Sports Medicine
Alkaptonuria (AKU) is a low-prevalence genetic inherited disease expressed in an autosomal recessive and monogenic manner, characterized by a tissue accumulation of homogentisic acid (HGA).
MARZO NUNES SANTOS, RICARDO DAVID COUTO, DANIELE BRUSTOLIM   +2 more
doaj   +2 more sources

The not so familiar silent joint killer: Ochronosis – A case report with review of literature

Journal of Orthopaedic Diseases and Traumatology, 2022
Ochronosis is rarely considered a cause for knee synovitis due to its rare occurrence. It starts affecting the joint from the third decade onward causing premature joint damage.
Gowtham Bandi, Ram Kartheek Randhi, Jameer Shaik, Varun Kumar Paka, Raviteja V S. Seerapu   +4 more
doaj   +1 more source

Dermabrasion in exogenous ochronosis: a therapeutic option [PDF]

Surgical & Cosmetic Dermatology, 2023
Exogenous ochronosis is a stigmatizing dermatosis characterized by asymptomatic, bluish-black, or grayish macules in photoexposed areas. Associated with the prolonged use of hydroquinone for the treatment of dyschromias, it has a broad therapeutic ...
Cintia Navarro Lamas, Fatima Maria de Oliveira Rabay, Elisangela Manfredini Andraus de Lima, Flávia Regina Ferreira, Veridiana de Paula Santos Miranda, Fernanda da Rocha Gonçalves   +5 more
doaj   +1 more source

An Unusual Presentation of Ochronosis with Palmar Pigmentation [PDF]

Journal of Clinical and Diagnostic Research, 2019
Ochronosis is the deposition of homogentisic acid in connective tissues resulting in bluish black discolouration. Hereby a case of ochronosis over the palmar surface of hand in 41-year-old male patient has been reported.
Mohan Rao Nandam, Shanthi Vissa, Syam Sundara Rao Byna, Bhavana Grandhi, Sujitha Raguraman   +4 more
doaj   +1 more source

Alkaptonuric ochronosis

Journal of Research in Medical Sciences, 2015
Ahad Azami, Nasrollah Maleki
doaj   +3 more sources

Subclinical Ochronosis Features In Alkaptonuria: A Cross-Sectional Study [PDF]

, 2019
Background Alkaptonuria (AKU) is present from birth, yet clinical effects are considered to appear later in life. Morbidity of AKU, considered irreversible, is secondary to ochronosis. Age of ochronosis onset is not clearly known.
Gallagher, JA, West, E, Rhodes, N, Milan, AM, Cox, TF, Taylor, S, Giustarini, D, Khedr, M, Misty, A, Braconi, D, Santucci, A, Shepherd, HR, Barton, GJ, Dillon, J, Hughes, A, Cox, T, Psarelli, EE, Rossi, R, Mistry, A, Ranganath, L, Robinson, MA, Taylor, LF, Sireau, N, Barton, G, Milan, A, Shepherd, H, Robinson, M, Dillon, JP, Genovese, F, Ranganath, LR   +29 more
core   +2 more sources

Exogenous Ochronosis: Characterizing a Rare Disorder in Skin of Color

, 2023
Exogenous ochronosis is a rare dyschromia that primarily impacts those with skin of color. It is characterized by blue–black pigmentation and is associated with the long-term application of skin-lightening creams containing hydroquinone.
Michelle Lazar, Neelam A. Vashi, Henriette De La Garza   +2 more
core   +1 more source

Advances in Skin Whitening Agents: Mechanisms, Clinical Applications, and Future Perspectives [PDF]

J Cosmet Dermatol
ABSTRACT Background Skin hyperpigmentation disorders are common cosmetic and clinical concerns caused by excessive melanin production, abnormal pigment distribution, or persistent pigment after inflammation. Their heterogeneous pathogenesis and tendency to recur complicate treatment, particularly in patients with darker phototypes.
Chen Y, Wang E, Li Y, Yang Y, Zhang Z, Wang J, Jiang Y, Zhao C.   +7 more
europepmc   +2 more sources

Reversal of ochronotic pigmentation in alkaptonuria following nitisinone therapy: Analysis of data from the United Kingdom National Alkaptonuria Centre

JIMD Reports, 2020
Background Increased homogentisic acid (HGA) causes ochronosis. Nitisinone decreases HGA. The aim was to study the effect of nitisinone on the ochronosis progression.
Lakshminarayan R. Ranganath, Anna M. Milan, Andrew T. Hughes, Milad Khedr, Andrew S. Davison, Peter J. Wilson, Jane P. Dillon, Elizabeth West, James A. Gallagher   +8 more
doaj   +1 more source

Long-term follow-up of bilateral hip and knee arthroplasty secondary to ochronotic arthropathy

Arthroplasty Today, 2020
Alkaptonuria is a rare metabolic disorder caused by the deficiency of homogentisic acid oxidase enzyme, which is responsible for eliminating homogentisic acid from the body through the renal system.
Imran Ilyas, MD, Syed Kashif, MD, Majed F. Algashiri, MD, Samar A. Rabbani, MD, Sahar S. Aldakhil, MD, Omar A. Al-Mohrej, MD   +5 more
doaj   +1 more source