Results 21 to 30 of about 2,691 (207)
Pigmented Rings With Central Clearing: A Dermoscopic Feature of Melasma. [PDF]
Australas J DermatolABSTRACT Melasma, a challenging pigmentary disorder affecting the face, often poses diagnostic difficulties due to its similarity to numerous other conditions. This study aimed to introduce and evaluate a novel dermoscopic feature, pigmented rings with central clearing (PRCC), in aiding the diagnosis of melasma and distinguishing it from similar ...
Punchihewa N +5 more
europepmc +2 more sources
Tyrosinase, could it be a missing link in ochronosis in alkaptonuria? [PDF]
, 2016 The hypothesis that is proposed is that tyrosinase, an enzyme widely found within the human body is implicated in the ochronosis that occurs in alkaptonuria; an autosomal recessive condition first used by Archibald Garrod to describe the theory of ...
Bleakley, Aaron +2 more
core +1 more source
A role for interleukins in ochronosis in a chondrocyte in vitro model of alkaptonuria [PDF]
, 2016 Objectives Alkaptonuria is a rare autosomal recessive condition resulting from inability to breakdown homogentisic acid (HGA); an intermediate in tyrosine degradation.
Bukhari, Marwan +3 more
core +1 more source
Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice. [PDF]
, 2015 Alkaptonuria (AKU) is an ultrarare autosomal recessive disorder resulting from a deficiency of homogentisate 1,2 dioxygenase (HGD), an enzyme involved in the catabolism of phenylalanine and tyrosine.
A Schulz +10 more
core +1 more source
Long-term follow-up of bilateral hip and knee arthroplasty secondary to ochronotic arthropathy
Arthroplasty Today, 2020 Alkaptonuria is a rare metabolic disorder caused by the deficiency of homogentisic acid oxidase enzyme, which is responsible for eliminating homogentisic acid from the body through the renal system.
Imran Ilyas, MD +5 more
doaj +1 more source
Alkaptonuuriast põhjustatud aordiklapi kitsenemus, südame pärgarteri haigus, teisene osteoartroos ja nende kirurgiline ravi [PDF]
, 2013 Alkaptonuuria on haruldane, progresseeruv ja pöördumatu geneetiline ainevahetushaigus. Klassikalise kliinilise triaadina esinevad selle korral homogentisiinhappe eritus uriiniga, sidekoe (eriti kõhrkoe) pigmentatsioon ning degeneratiivne liigesepõletik ...
Jõeste, Enn +5 more
core +2 more sources
JIMD Reports, 2020 Background Increased homogentisic acid (HGA) causes ochronosis. Nitisinone decreases HGA. The aim was to study the effect of nitisinone on the ochronosis progression.
Lakshminarayan R. Ranganath +8 more
doaj +1 more source
, 2013 Alkaptonuria (AKU) is a rare disorder of autosomal recessive inheritance. It is caused by a mutation in a gene that results in the accumulation of homogentisic acid (HGA).
Bukhari, Marwan +2 more
core +1 more source
Targeting Melasma: Innovations in Pigment Deposition and Photoaging in Cosmetic Dermatology. [PDF]
J Cosmet DermatolABSTRACT Background Melasma is a chronic, relapsing hyperpigmentation disorder driven by complex interactions among genetic predisposition, hormonal fluctuations, UV exposure, oxidative stress, inflammation, and photoaging. Its psychosocial impact is substantial, especially among women with darker skin types, and treatment remains challenging due to ...
Liao T, Luo R, Deng Y, Yang H, Du Y.
europepmc +2 more sources
Ochronotic Arthropathy: A Report of Two Cases
Southern Clinics of Istanbul Eurasia, 2020 Ochronosis is an entity characterized by deposition of homogentisic acid and metabolites in connective tissues, such as joint cartilage, skin and sclera.
Selma Şengiz Erhan +3 more
doaj +1 more source