Exogenous ochronosis after prolonged use of topical hydroquinone (2%) in a 50-year-old Indian female
Indian Journal of Dermatology, 2012 Ochronosis is a rare disease characterized by speckled and diffuse pigmentation symmetrically over the face, neck, and photo-exposed areas. It is characterized histologically by banana-shaped ochre-colored deposits in the dermis.
Vijay Gandhi +2 more
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A Dark Turn in the OR: Incidental Discovery of Ochronosis during Trauma Surgery: A Case Report [PDF]
Journal of Orthopaedic Case ReportsIntroduction: Alkaptonuria is a rare autosomal recessive metabolic disorder caused by deficiency of homogentisic acid (HGA) oxidase, leading to the accumulation of HGA. The polymerized oxidation products of HGA in connective tissues, a condition known as
Kumar Parth +5 more
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Cardiovascular involvement in Alcaptonuria: a case report on ochronotic aortic valve [PDF]
Journal of Cardiothoracic SurgeryAlcaptonuria is a rare autosomal recessive metabolic disorder. It is characterized by the accumulation of homogentisic acid–derived brown and bluish-black pigments in connective tissues, a condition known as ochronosis. This occurs due to a defect in the
Alizamin Yusifli +5 more
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Ochronosis as an unusual cause of valvular defect: a case report [PDF]
Journal of Medical Case Reports, 2009 Introduction Alkaptonuria (also known as ochronosis) is a genetic disorder characterised by the accumulation of homogentisic acid deposits in connective tissue. In rare cases, ochronosis can cause valvular heart disease.
Steverding Dietmar, Wilke Andreas
doaj +3 more sources
Ochronotic arthropathy: skeletal manifestations and orthopaedic treatment [PDF]
EFORT Open ReviewsAlkaptonuria is an extremely rare disorder of tyrosine metabolism caused by an autosomal recessive enzymatic deficiency of homogentisic acid (HGA) oxidase, causing its accumulation in collagenous structures, especially in hyaline cartilage.
Khaled Hamed Salem, Alyaa Diaa Elmoghazy
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Ochronotic arthropathy mimicking degenerative osteoarthritis in an older adult with alkaptonuria: diagnostic and perioperative lessons from a case report [PDF]
Frontiers in MedicineBackgroundAlkaptonuria is a rare inherited metabolic disorder caused by impaired homogentisic acid metabolism. Ochronotic arthropathy is a late musculoskeletal manifestation and may mimic ordinary degenerative osteoarthritis in older adults.
Yong-Ming Zhang +3 more
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Treatment modalities for exogenous ochronosis: A narrative review of current and emerging therapeutic approaches. (Treatment of exogenous ochronosis) [PDF]
Surgical & Cosmetic DermatologyExogenous ochronosis is a chronic skin disorder characterized by dermal hyperpigmentation, often resulting from prolonged use of hydroquinone. This review analyzed 29 studies (2000-2025) assessing treatments for exogenous ochronosis.
Emmanuela Dapomaa Asante +1 more
doaj +2 more sources
Ochronotic Arthropathy of the Shoulder – A Rare Case Report [PDF]
Journal of Orthopaedic Case ReportsIntroduction: Alkaptonuria is a metabolic disorder due to accumulation of homogentisic acid, leading to destruction of major joints. Very few cases of ochronosis with shoulder involvement have been reported in literature. Case Report: We report a 31-year-
Ayyappan V Nair +5 more
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Non-cemented Total Hip Arthroplasty in a Rare Case with Black Hip, A Case Report [PDF]
Advanced Biomedical ResearchAlkaptonuria is a metabolic disorder characterized by homogentisic acid accumulation in connective tissue. Ochronotic arthropathy, a rare condition reported in alkaptonuria, mostly affects the knee joint.
Ramin Shayan-Moghadam +3 more
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Ochronosis – a rare metabolic disease [PDF]
Romanian Journal of Rheumatology, 2021 Alkaptonuria is a rare disorder, an autosomal recessive condition with genetic determinism and hereditary transmission, having a prevalence of 1 per 1 million population in USA.
Patricia Richter +4 more
doaj +1 more source