Results 21 to 30 of about 6,939 (158)

Ochronotic Chronic Tendoachilles Rupture Management: A Case Series [PDF]

Journal of Foot and Ankle Surgery (Asia Pacific)
Background: Alkaptonuria is a rare inherited genetic disorder in which there is a deficiency of the enzyme homogentisate 1,2-dioxygenase. The three characteristics of alkaptonuria are homogentisic-aciduria, ochronosis, and ochronotic arthropathy ...
Jeremy B Dorai, Issac Jebaraj
doaj   +2 more sources

Non-cemented Total Hip Arthroplasty in a Rare Case with Black Hip, A Case Report [PDF]

Advanced Biomedical Research
Alkaptonuria is a metabolic disorder characterized by homogentisic acid accumulation in connective tissue. Ochronotic arthropathy, a rare condition reported in alkaptonuria, mostly affects the knee joint.
Ramin Shayan-Moghadam, Hasan Zolghadr, Erfan Babaei-Nejad, Hossein Shafiee   +3 more
doaj   +2 more sources

First Documented Hip Replacement in a Palestinian Patient with Ochronotic Alkaptonuria Arthropathy: A Case Report [PDF]

Journal of Orthopaedic Case Reports
Introduction: Alkaptonuria (AKU) is a genetic disease caused by a deficiency in the homogentisate 1,2-dioxygenase enzyme. This deficiency leads to elevated levels of homogentisic acid and its oxidized form, benzoquinone acetic acid.
Saleh Shalalfa, Neveen Shalalfa, Javid Mohammadzadeh Azarabadi, Ahmed Nafiz Barakat   +3 more
doaj   +2 more sources

Ochronotic Arthropathy [PDF]

Arthritis & Rheumatology, 2017
Jafri, Kashif, Gensler, Lianne S, Link, Thomas M   +2 more
core   +5 more sources

Black Femoral Head Due to Ochronotic Arthropathy: A Case Report

Journal of Orthopedic and Spine Trauma, 2021
Background: Ochronotic arthropathy is a rare complication in patients with alkaptonuria (AKU) that occurs as a result of ochronotic pigment accumulation in the joints.
Mahlisha Kazemi, Hamid Rabie, Mohammad Hasan sharafi   +2 more
doaj   +1 more source

An Unusual Case of Bilateral Ochronotic Arthropathy of the Hip Successfully Managed by a Staged Bilateral Total Hip Replacement- An Insight with a Surgical Note. [PDF]

J Orthop Case Rep, 2018
Ochronosis is an inherited metabolic disease that causes a brownish-black pigmentation of the connective tissue. There is currently no specific treatment for ochronosis. The goal of treatment is to control the progress of disease with a multidisciplinary
Fernando OSF, Supreeth N, David GD, Borja L, Ricardo L.   +4 more
europepmc   +2 more sources

Ipsilateral hip and knee joints ochronotic arthropathy treated by total joint replacement, a case report

Bulletin of the National Research Centre, 2022
Background Ochronotic arthropathy affecting the hip and knee joints is one of the musculoskeletal manifestations of alkaptonuria which results from a tyrosine amino acid metabolism disorder.
Ahmed A. Khalifa, Mohamed M. A. Moustafa, Hatem Bakr, Ahmed M. Abdelaal   +3 more
doaj   +1 more source

Increased prevalence of Parkinson's disease in alkaptonuria

JIMD Reports, Volume 64, Issue 4, Page 282-292, July 2023., 2023
Abstract Amongst a cohort of 88 alkaptonuria (AKU) patients attending the United Kingdom National Alkaptonuria Centre (NAC), four unrelated patients had co‐existing Parkinson's disease (PD). Two of the NAC patients developed PD before receiving nitisinone (NIT) while the other two developed overt PD during NIT therapy.
Lakshminarayan Ranganath, Milad Khedr, Anna M. Milan, Andrew S. Davison, Brendan P. Norman, Mirian C. H. Janssen, Edward Lock, George Bou‐Gharios, James A. Gallagher   +8 more
wiley   +1 more source

The black bone disease: a case report of ochronotic hip arthropathy [PDF]

, 2022
Ochronotic arthropathy is a rare complication in patients with alkaptonuria (AKU) that arises as a result of accumulation of ochronotic pigment in the joints. This case report presented a 70-year-old female patient with chronic pain in B/L knee and right
Kumar, B. L., Garg, Shivam, Rathi, Rahul, ., Vishwas   +3 more
core   +1 more source

Dilemmas in the diagnosis and management of osteoporosis in a patient with alkaptonuria: Successful treatment with teriparatide

Clinical Case Reports, Volume 10, Issue 12, December 2022., 2022
We report the first case of long‐term follow‐up of a 69‐year‐old woman who developed fragility fractures despite receiving bisphosphonate therapy and was successfully treated with teriparatide, an anabolic agent. Abstract Management of osteoporosis in patients with alkaptonuria can be challenging.
Ismail C. Ebrahim, Thanh D. Hoang, Nicole O. Vietor, John P. Schacht, Mohamed K. M. Shakir   +4 more
wiley   +1 more source