Results 31 to 40 of about 7,435 (127)

Black Femoral Head Due to Ochronotic Arthropathy: A Case Report

Journal of Orthopedic and Spine Trauma, 2021
Background: Ochronotic arthropathy is a rare complication in patients with alkaptonuria (AKU) that occurs as a result of ochronotic pigment accumulation in the joints.
Mahlisha Kazemi, Hamid Rabie, Mohammad Hasan sharafi   +2 more
doaj   +1 more source

An Unusual Case of Bilateral Ochronotic Arthropathy of the Hip Successfully Managed by a Staged Bilateral Total Hip Replacement- An Insight with a Surgical Note. [PDF]

J Orthop Case Rep, 2018
Ochronosis is an inherited metabolic disease that causes a brownish-black pigmentation of the connective tissue. There is currently no specific treatment for ochronosis. The goal of treatment is to control the progress of disease with a multidisciplinary
Fernando OSF, Supreeth N, David GD, Borja L, Ricardo L.   +4 more
europepmc   +2 more sources

Ipsilateral hip and knee joints ochronotic arthropathy treated by total joint replacement, a case report

Bulletin of the National Research Centre, 2022
Background Ochronotic arthropathy affecting the hip and knee joints is one of the musculoskeletal manifestations of alkaptonuria which results from a tyrosine amino acid metabolism disorder.
Ahmed A. Khalifa, Mohamed M. A. Moustafa, Hatem Bakr, Ahmed M. Abdelaal   +3 more
doaj   +1 more source

Increased prevalence of Parkinson's disease in alkaptonuria

JIMD Reports, Volume 64, Issue 4, Page 282-292, July 2023., 2023
Abstract Amongst a cohort of 88 alkaptonuria (AKU) patients attending the United Kingdom National Alkaptonuria Centre (NAC), four unrelated patients had co‐existing Parkinson's disease (PD). Two of the NAC patients developed PD before receiving nitisinone (NIT) while the other two developed overt PD during NIT therapy.
Lakshminarayan Ranganath, Milad Khedr, Anna M. Milan, Andrew S. Davison, Brendan P. Norman, Mirian C. H. Janssen, Edward Lock, George Bou‐Gharios, James A. Gallagher   +8 more
wiley   +1 more source

The black bone disease: a case report of ochronotic hip arthropathy [PDF]

, 2022
Ochronotic arthropathy is a rare complication in patients with alkaptonuria (AKU) that arises as a result of accumulation of ochronotic pigment in the joints. This case report presented a 70-year-old female patient with chronic pain in B/L knee and right
Kumar, B. L., Garg, Shivam, Rathi, Rahul, ., Vishwas, Vishwas ., Shivam Garg, B. L. Kumar, Rahul Rathi   +7 more
core   +1 more source

Dilemmas in the diagnosis and management of osteoporosis in a patient with alkaptonuria: Successful treatment with teriparatide

Clinical Case Reports, Volume 10, Issue 12, December 2022., 2022
We report the first case of long‐term follow‐up of a 69‐year‐old woman who developed fragility fractures despite receiving bisphosphonate therapy and was successfully treated with teriparatide, an anabolic agent. Abstract Management of osteoporosis in patients with alkaptonuria can be challenging.
Ismail C. Ebrahim, Thanh D. Hoang, Nicole O. Vietor, John P. Schacht, Mohamed K. M. Shakir   +4 more
wiley   +1 more source

Blue man: Ochronosis in Otolaryngology

Clinical Case Reports, Volume 10, Issue 4, April 2022., 2022
There are several physical examination findings indicative of ochronosis in Otolaryngology. Although these discoveries can be alarming, they are not harmful and can be observed. When young patients are found to have ochronosis, a newly discovered medication can be taken to lessen the development of these physical manifestations.
Karuna Dewan, Charles Bruce MacDonald, Courtney B. Shires   +2 more
wiley   +1 more source

Vitiligo, alkaptonuria, and nitisinone—A report of three families and review of the literature

JIMD Reports, Volume 61, Issue 1, Page 25-33, September 2021., 2021
Abstract Four patients, from three families, with alkaptonuria receiving 4‐hydroxyphenylpyruvate dioxygenase‐inhibiting nitisinone therapy, which lowers homogentisic acid and increases tyrosine, developed vitiligo. Three of the four patients were receiving nitisinone 2 mg daily, while the fourth was on 10 mg daily.
Lakshminarayan Ranganath, Milad Khedr, Leanne A. Evans, Helen Bygott, Emily Luangrath, Elizabeth West   +5 more
wiley   +1 more source

Hip and knee replacement in patients with ochronosis: Clinical experience and literature review

Orthopedic Reviews, 2020
Patients with alkaptonuria can present ochronotic degenerative arthropathy due to the accumulation of pigments in the cartilages. Ochronotic arthropathy initially affects the spine, then there is the involvement of the other large joints, with greater ...
Cesare Meschini, Michele Cauteruccio, Maria Serena Oliva, Giuseppe Sircana, Raffaele Vitiello, Giuseppe Rovere, Francesco Muratori, Giulio Maccauro, Antonio Ziranu   +8 more
doaj   +1 more source

Prótesis total de rodilla en paciente diagnosticada de artropatía ocronótica

Revista Española de Cirugía Ortopédica y Traumatología, 2021
Resumen: La ocronosis es una enfermedad genética rara del metabolismo de la fenilamina y de la tirosina en la que se produce una acumulación de ácido homogentísico. La acumulación de este provoca alcaptonuria y depósito en el tejido conectivo, provocando
M. Sabater, A. Alías, J.M. Segur
doaj   +1 more source