Results 51 to 60 of about 7,435 (127)

Black Colouration of the Knee Articular Cartilage after Spontaneously Recurrent Haemarthrosis

Case Reports in Orthopedics, Volume 2016, Issue 1, 2016., 2016
Mild discolouration of the articular cartilage is known to gradually occur during aging. However, pathological tissue pigmentation is occasionally induced under several specific conditions. In the present case, we performed total knee replacement in a patient with recurrent haemarthrosis.
Kazu Matsumoto, Daichi Ishimaru, Hiroyasu Ogawa, Haruhiko Akiyama, Paul E. Di Cesare   +4 more
wiley   +1 more source

Patients with Black Hip and Black Knee Due to Ochronotic Arthropathy: Case Report and Review of Literature [PDF]

, 2020
Ochronotic arthropathy is a manifestation of longstanding alkaptonuria. With increasing age, an accumulation of pigment deposits of homogentisic acid in the joint cartilage results in ochronotic osteoarthritis.
Ali Mehmet, Hakan Altan, Ömer Faruk Acar, Mehmet Elmadağ, Egemen Aydin, Nuh Şenaran, Bahattin Kerem Erkocak   +6 more
core  

In Vivo Confocal Microscopy and Anterior Segment Optic Coherence Tomography Findings in Ocular Ochronosis

Case Reports in Ophthalmological Medicine, Volume 2015, Issue 1, 2015., 2015
Purpose. To report clinical and in vivo confocal microscopy (IVCM) findings of two patients with ocular ochronosis secondary due to alkaptonuria. Materials and Methods. Complete ophthalmologic examinations, including IVCM (HRT II/Rostock Cornea Module, Heidelberg, Germany), anterior segment optical coherence tomography (AS‐OCT) (Topcon 3D spectral ...
Elif Demirkilinc Biler, Suzan Guven Yilmaz, Melis Palamar, Pedram Hamrah, Afsun Sahin, Alexander A. Bialasiewicz   +5 more
wiley   +1 more source

Amyloidosis, Inflammation, and Oxidative Stress in the Heart of an Alkaptonuric Patient

Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
Background. Alkaptonuria, a rare autosomal recessive metabolic disorder caused by deficiency in homogentisate 1,2‐dioxygenase activity, leads to accumulation of oxidised homogentisic acid in cartilage and collagenous structures present in all organs and tissues, especially joints and heart, causing a pigmentation called ochronosis.
Lia Millucci, Lorenzo Ghezzi, Eugenio Paccagnini, Giovanna Giorgetti, Cecilia Viti, Daniela Braconi, Marcella Laschi, Michela Geminiani, Patrizia Soldani, Pietro Lupetti, Maurizio Orlandini, Chiara Benvenuti, Federico Perfetto, Adriano Spreafico, Giulia Bernardini, Annalisa Santucci, Giuseppe Valacchi   +16 more
wiley   +1 more source

Spinal Abnormalities Similar To Ankylosing-Spondylitis In a 58-Year-Old Woman With Ochronosis

, 1995
Ochronotic arthropathy (spondylosis or peripheral arthropathy) is a late complication of alkaptonuria. There is a tendency for HLA-B27 positive patients with alkaptonuria to develop ochronotic spondylosis.
Ozmen, D, Kabasakal, Y, Yagci, A, Gumusdis, G, Kiyici, I   +4 more
core   +2 more sources

Patellar ligament rupture during total knee arthroplasty in an ochronotic patient

Acta Orthopaedica et Traumatologica Turcica, 2020
Ochronotic arthropathy mainly involves the spine and large joints. Along with blackening of the joint, degeneration rapidly progresses mostly in the knee, resulting in symptoms by the 4th or 5th decade.
Madan Mohan Sahoo, Sudhir Kumar Mahapatra, Gopal Chandra Sethi, Sunil Kumar Dash   +3 more
doaj   +1 more source

Analysis of the Phenotype Differences in Siblings with Alkaptonuria

Metabolites, 2022
Alkaptonuria (AKU) is a rare autosomal recessive disorder caused by mutations within a gene coding for homogentisate 1,2-dioxygenase (HGD). To date, 251 different variants of this gene have been reported.
Andrea Zatkova, Birgitta Olsson, Lakshminarayan R. Ranganath, Richard Imrich   +3 more
doaj   +1 more source

Treatment of Nongout Joint Deposition Diseases: An Update

Arthritis, Volume 2014, Issue 1, 2014., 2014
This update develops the actual therapeutic options in the management of the joint involvement of calcium pyrophosphate deposition disease (CPPD), basic calcium phosphate (BCP) deposition disease, hemochromatosis (HH), ochronosis, oxalosis, and Wilson’s disease. Conventional pharmaceutical treatment provides benefits for most diseases.
Tristan Pascart, Pascal Richette, René-Marc Flipo, Ruben Burgos-Vargas   +3 more
wiley   +1 more source

An anatomical investigation of alkaptonuria: Novel insights into ochronosis of cartilage and bone

Journal of Anatomy, Volume 246, Issue 6, Page 1053-1074, June 2025.
Examination of an alkaptonuria body highlights the susceptibility of all cartilage types and associated perichondrium to ochronotic pigmentation and the heterogeneity of ochronotic pigment distribution both within and between tissues. In joints, calcified cartilage pigments before non‐calcified cartilage.
Juliette H. Hughes, Gemma Charlesworth, Amanda Prior, Claire M. Tierney, Paul D. Rothwell, Neil P. Thomas, Lakshminarayan R. Ranganath, James A. Gallagher, Alistair P. Bond   +8 more
wiley   +1 more source

An in vitro cell model for exploring inflammatory and amyloidogenic events in alkaptonuria

Journal of Cellular Physiology, Volume 239, Issue 12, December 2024.
Abstract Alkaptonuria (AKU) is a progressive systemic inherited metabolic disorder primarily affecting the osteoarticular system, characterized by the degeneration of cartilage induced by ochronosis, ultimately leading to early osteoarthritis (OA).
Pierfrancesco Mastroeni, Michela Geminiani, Tommaso Olmastroni, Luisa Frusciante, Alfonso Trezza, Anna Visibelli, Annalisa Santucci   +6 more
wiley   +1 more source