Results 51 to 60 of about 6,939 (158)

Treatment of Nongout Joint Deposition Diseases: An Update

Arthritis, Volume 2014, Issue 1, 2014., 2014
This update develops the actual therapeutic options in the management of the joint involvement of calcium pyrophosphate deposition disease (CPPD), basic calcium phosphate (BCP) deposition disease, hemochromatosis (HH), ochronosis, oxalosis, and Wilson’s disease. Conventional pharmaceutical treatment provides benefits for most diseases.
Tristan Pascart, Pascal Richette, René-Marc Flipo, Ruben Burgos-Vargas   +3 more
wiley   +1 more source

Haemophilia and joint disease: pathophysiology, evaluation and management [PDF]

, 2011
In patients with haemophilia, regular replacement therapy with clotting factor concentrates (prophylaxis) is effective in preventing recurrent bleeding episodes into joints and muscles.
Erik Berntorp, Knobe, Karin, Karin Knobe, Berntorp, Erik   +3 more
core   +1 more source

Total Knee Arthroplasty in Alkaptonuric Ochronosis: the First Case Report in Thailand and Literature Review

Siriraj Medical Journal, 2016
Ochronosis is a musculoskeletal manifestation found in alkaptonuria which is a rare autosomal recessive disorder caused by the deficiency of homogentistic acid oxidase enzyme. This leads to accumulation and deposition of homogentistic acid (HGA) pigments
Witchuree Wejjakul, Anuwat Pongkunakorn
doaj   +3 more sources

Patients with Black Hip and Black Knee Due to Ochronotic Arthropathy: Case Report and Review of Literature [PDF]

, 2020
Ochronotic arthropathy is a manifestation of longstanding alkaptonuria. With increasing age, an accumulation of pigment deposits of homogentisic acid in the joint cartilage results in ochronotic osteoarthritis.
Ali Mehmet, Hakan Altan, Ömer Faruk Acar, Mehmet Elmadağ, Egemen Aydin, Nuh Şenaran, Bahattin Kerem Erkocak   +6 more
core  

Raman Spectroscopy identifies differences in ochronotic and non-ochronotic cartilage : a potential novel technique for monitoring ochronosis [PDF]

, 2019
Objective Alkaptonuria (AKU) is a rare, inherited disorder of tyrosine metabolism, where patients are unable to breakdown homogentisic acid (HGA), which increases systemically over time.
Jenks, Daniel, Dillon, Jane, Taylor, Adam Michael, Kammath, Vishnu, Gallagher, James, Norman, Brendan, Kerns, Jemma Gillian, Ranganath, Lakshminarayan   +7 more
core   +4 more sources

An anatomical investigation of alkaptonuria: Novel insights into ochronosis of cartilage and bone

Journal of Anatomy, Volume 246, Issue 6, Page 1053-1074, June 2025.
Examination of an alkaptonuria body highlights the susceptibility of all cartilage types and associated perichondrium to ochronotic pigmentation and the heterogeneity of ochronotic pigment distribution both within and between tissues. In joints, calcified cartilage pigments before non‐calcified cartilage.
Juliette H. Hughes, Gemma Charlesworth, Amanda Prior, Claire M. Tierney, Paul D. Rothwell, Neil P. Thomas, Lakshminarayan R. Ranganath, James A. Gallagher, Alistair P. Bond   +8 more
wiley   +1 more source

Alkaptonuria and Ochronotic Arthropathy: The Path to Pain-Free Mobility

Case Reports in Clinical Practice
This article discusses a case of ochronotic arthropathy, a manifestation of alkaptonuria. Alkaptonuria is characterized by the accumulation of homogentisic acid [HGA] in tissues, leading to a distinctive blue-black pigmentation and early joint ...
Mohammad Poursalehian, Mohammadreza Barzegar, Mohammadreza Razzaghof, Seyed Mohammad Javad Mortazavi   +3 more
doaj   +1 more source

An in vitro cell model for exploring inflammatory and amyloidogenic events in alkaptonuria

Journal of Cellular Physiology, Volume 239, Issue 12, December 2024.
Abstract Alkaptonuria (AKU) is a progressive systemic inherited metabolic disorder primarily affecting the osteoarticular system, characterized by the degeneration of cartilage induced by ochronosis, ultimately leading to early osteoarthritis (OA).
Pierfrancesco Mastroeni, Michela Geminiani, Tommaso Olmastroni, Luisa Frusciante, Alfonso Trezza, Anna Visibelli, Annalisa Santucci   +6 more
wiley   +1 more source

Ochronotic arthropathy, an approach to osteoarthritis bone remodelling [PDF]

, 2018
The objective is to use hip ochronotic arthropathy for an indirect approach to osteoarthritis bone remodelling in a human joint via an identified causal chondropathy.
Lagier, René
core  

Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment.

, 2010
SIR, we report a female with known alkaptonuria (AKU) undergoing routine hip replacement surgery due to alkaptonuric arthropathy. AKU is caused by a deficiency in the enzyme that breaks down homogentisic acid (HGA), resulting in elevated circulation of ...
Taylor, Adam, Wilson, P. J. M., Ranganath, L. R., Gallagher, J. A., Prior, Ian A., Jarvis, Jonathan C., Wlodarski, Brenda   +6 more
core   +4 more sources