Results 51 to 60 of about 2,466,202 (266)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Surveillance for ocular hypertension : an evidence synthesis and economic evaluation [PDF]

, 2012
OBJECTIVES: To determine effective and efficient monitoring criteria for ocular hypertension [raised intraocular pressure (IOP)] through (i) identification and validation of glaucoma risk prediction models; and (ii) development of models to determine ...
Banister, K, Burr, JM, Kotecha, A, Garway-Heath, D., H Lemij, M Ryan, Tuulonen, A., Vale, L., Fraser, C., R Sanders, Crabb, D, Kotecha, A., Cook, J, Y Takwoingi, S Vernon, Takwoingi, Y., Banister, K., Fraser, C, Deeks, J, Sanders, R, A Tuulonen, Cook, J., Hernández, R, Glasziou, P, Tuulonen, A, Lemij, H., Vale, L, Burr, Jennifer Margaret, Elders, A., Burr, J.M., R Asaoka, Takwoingi, Y; id_orcid, Azuara-Blanco, A, P Glasziou, Botello-Pinzon, P, Garway-Heath, D, Ryan, Mandy, Vazquez-Montes, M, Lemij, H, Deeks, J., Takwoingi, Y, D Crabb, Azuara-Blanco, A.; id_orcid, L Vale, A Azuara-Blanco, Perera, R., Ryan, M, van der Schoot, J, Perera, R, Sanders, R., Crabb, D., Elders, A, D Garway-Heath, Ryan, M., R Hernández, K Banister, C Fraser, J Cook, J van der Schoot, Botello-Pinzon, P., A Elders, A Kotecha, Glasziou, P., Azuara-Blanco, A., King, A., J Deeks, JM Burr, A King, Burr, J M, Glasziou, Paul, King, A, Vernon, S, Asaoka, R., Vazquez-Montes, M., van der Schoot, J., Vernon, S., M Vazquez-Montes, Perera, Rafael, R Perera, Asaoka, R, Hernandez, R., P Botello-Pinzon, Azuara-Blanco, Augusto; id_orcid, King, Anthony J, Deeks, Jonathan J, Burr, Jennifer M, Azuara-Blanco, Augusto, Botello, Adriana P, Sanders, Roshini, Takwoingi, Yemisi, Garway-Heath, David F, Takwoingi, Yemisi; id_orcid, Lemij, Hans G   +92 more
core   +1 more source

Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases [PDF]

, 2020
Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressant ...
Hoz Montañana, María Rosa De, Pinazo Durán, María Dolores, Fernández Albarral, José, Salazar Corral, Juan José, Ramírez Sebastián, Ana Isabel, Ramírez Sebastián, José Manuel, López Cuenca, Inés, García Martín, Elena Salobrar   +7 more
core   +1 more source

Associations between vision impairment and multimorbidity among older Chinese adults: results from the China health and retirement longitudinal study

BMC Geriatrics, 2023
Background Although several studies have reported the relationship between vision impairment (VI) and multimorbidity in high-income countries, this relationship has not been reported in low- and middle-income countries.
Kun Xiong, Huiyan Mao, Qi’ao Zhang, Changrong Lei, Yuanbo Liang   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The effect of corneal power on the accuracy of 14 IOL power formulas

BMC Ophthalmology
Background This study evaluates the impact of corneal power on the accuracy of 14 newer intraocular lens (IOL) calculation formulas in cataract surgery.
Jialin Xu, Lu Zhang, Er Mo, Kaiyi Zhu, Yitong Zhu, Ke Feng, Zunting Wu, Yangran Zheng, Fang Huang, Xianhui Gong, Jin Li   +10 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Ocular rosacea

, 2005
Rosacea is a common skin disease that frequently involves the eye. Although the pathogenesis of the disease remains undefined, recent findings suggest that an altered inflammatory response plays an important role in both cutaneous and ocular rosacea ...
Mannis, Mark J. [UNIFESP], Alvarenga, Lênio Souza [UNIFESP]   +1 more
core   +1 more source

In vivo biomechanical property detection of the ciliary muscle based on optical coherence tomography and digital image correlation technology

Eye and Vision
Background This study aimed to develop and validate a digital image correlation (DIC) methodology based on swept-source optical coherence tomography (SS-OCT) for quantifying in vivo ciliary muscle (CM) deformation and strain during accommodation. Methods
Jingsong Wang, Shenglong Luo, Yixin Li, Shenao Yi, Ning Xu, Tong Wang, Yang Gao, Ruyu Yan, Fan Lu, Junjie Wang, Yilei Shao   +10 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source