Results 61 to 70 of about 1,894 (248)

Proteolytic Regulation of Synaptic Plasticity in the Mouse Primary Visual Cortex: Analysis of Matrix Metalloproteinase 9 Deficient Mice.

Frontiers in Cellular Neuroscience, 2015
The extracellular matrix (ECM) is known to play important roles in regulating neuronal recovery from injury. The ECM can also impact physiological synaptic plasticity, although this process is less well understood.
Emily A Kelly, Amanda S Russo, Cory D Jackson, Cassandra E Lamantia, Ania K Majewska   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Stable Learning of Functional Maps in Self-Organizing Spiking Neural Networks with Continuous Synaptic Plasticity

Frontiers in Computational Neuroscience, 2013
This study describes a spiking model that self-organizes for stable formation and maintenance of orientation and ocular dominance maps in the visual cortex (V1).
Narayan eSrinivasa, Qin eJiang
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Ocular dominance plasticity in mouse visual cortex is age-dependent.

, 2013
Representative experiments of animals in all four age groups studied (PD25, PD95, PD130 and PD215) are displayed. Optical imaging maps of responses to the ipsi- and contralateral eye in the binocular region of mouse visual cortex in both control animals (
Konrad Lehmann (53602), Siegrid Löwel (53603)   +1 more
core   +1 more source

Unraveling the mesoscale resting-state functional connectivity of ocular dominance columns in humans using high-resolution functional MRI

Communications Biology
Despite their importance for visual perception, functional connectivity between ocular dominance columns in human primary visual cortex remains largely unknown.
Marianna Elisa Schmidt, Iman Aganj, Jason Stockmann, Berkin Bilgic, Yulin Chang, William Scott Hoge, Evgeniya Kirilina, Nikolaus Weiskopf, Shahin Nasr   +8 more
doaj   +1 more source

Cholinergic Potentiation Alters Perceptual Eye Dominance Plasticity Induced by a Few Hours of Monocular Patching in Adults

Frontiers in Neuroscience, 2019
A few hours of monocular deprivation with a diffuser eye patch temporarily strengthens the contribution of the deprived eye to binocular vision. This shift in favor of the deprived eye is characterized as a form of adult visual plasticity.
Yasha Sheynin, Mira Chamoun, Alex S. Baldwin, Pedro Rosa-Neto, Robert F. Hess, Elvire Vaucher   +5 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Short-Term Monocular Deprivation Enhances Physiological Pupillary Oscillations

Neural Plasticity, 2017
Short-term monocular deprivation alters visual perception in adult humans, increasing the dominance of the deprived eye, for example, as measured with binocular rivalry.
Paola Binda, Claudia Lunghi
doaj   +1 more source