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2016
Although the eye is an accessible organ for direct drug application, ocular drug delivery remains a major challenge due to multiple barriers within the eye. Key barriers include static barriers imposed by the cornea, conjunctiva, and retinal pigment epithelium and dynamic barriers including tear turnover and blood and lymphatic clearance mechanisms ...
Burcin, Yavuz, Uday B, Kompella
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Although the eye is an accessible organ for direct drug application, ocular drug delivery remains a major challenge due to multiple barriers within the eye. Key barriers include static barriers imposed by the cornea, conjunctiva, and retinal pigment epithelium and dynamic barriers including tear turnover and blood and lymphatic clearance mechanisms ...
Burcin, Yavuz, Uday B, Kompella
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Review of Ocular Drug Delivery
Current Drug Delivery, 2006Successful treatment of eye diseases requires effective concentration of drug at the eye for sufficient period of time. Conventional ocular drug delivery including eye drops, systemic administration, ophthalmic ointments, is no longer sufficient to combat ocular diseases.
Yasmin, Sultana +3 more
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Advances in Ocular Drug Delivery
Current Eye Research, 2012Eye drops have long been the primary ocular drug delivery dosage form used to treat ocular disorders ranging from superficial conditions to intravitreal diseases. The ocular anatomical structure and physiological protective mechanisms are one of the most formidable barriers to drug penetration that have significantly reduced the drug's efficacy and ...
Rawas-Qalaji, Mutasem +1 more
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Nanomaterials for Ocular Drug Delivery
Macromolecular Bioscience, 2012AbstractEfficient drug delivery to the eye remains a challenging task for pharmaceutical scientists. Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye, conventional drug delivery systems, such as eye drop solutions, suffer from low bioavailability.
Shengyan, Liu +2 more
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Drug delivery from ocular implants
Expert Opinion on Drug Delivery, 2006Developing an intraocular drug delivery system (DDS) is urgently needed because most vitreoretinal diseases are refractory to conventional pharmacological approaches; eye drops and systemically administered drugs cannot deliver therapeutic drug concentrations into vitreoretinal tissue. Intraocular DDSs address this problem.
Tsutomu, Yasukawa +4 more
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Nanotechnology in ocular drug delivery
Drug Discovery Today, 2008Despite numerous scientific efforts, efficient ocular drug delivery remains a challenge for pharmaceutical scientists. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions and ointment. These conventional dosage forms suffer from the problems of poor ocular bioavailability, because of various anatomical and
Sanjeeb K, Sahoo +2 more
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Recent advances in ocular drug delivery
Drug Development and Industrial Pharmacy, 2012Amongst the various routes of drug delivery, the field of ocular drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientist. Recent research has focused on the characteristic advantages and limitations of the various drug delivery systems, and further research will be required before the ideal system can ...
Djamila, Achouri +3 more
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Ocular drug delivery conventional ocular formulations
Advanced Drug Delivery Reviews, 1995Abstract Within the last few decades, in response to the advent of potent and versatile therapeutic agents, the diversity of conventional ophthalmic formulations has gradually evolved, extending well beyond simple solutions, and now includes a variety of types of drug administration.
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Redefining ocular drug delivery
The Ocular Surface, 2022Allisa J. Song +2 more
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Ocular drug delivery in veterinary medicine
Advanced Drug Delivery Reviews, 1997This paper provides a comprehensive overview of the various approaches currently used in the development of ocular drug delivery systems for the treatment of ocular diseases in animals. It is obvious from the literature that most of the products that are currently available are derived from human medicine without consideration given to the differences ...
Baeyens, Vincent +5 more
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