Results 91 to 100 of about 4,998,430 (314)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Relationships between ocular surface sphingomyelinases, Meibum and Tear Sphingolipids, and clinical parameters of meibomian gland dysfunction

, 2022
Sphingolipids (SPL) are a class of lipid molecules that play important functional and structural roles in our body and are a component of meibum. Sphingomyelinases (SMases) are key enzymes in sphingolipid metabolism that hydrolyze sphingomyelin (SM) and ...
Mondal, Koushik, Mandal, Nawajes, Galor, Anat, Jensen, Katherine, Sanchez, Victor, Nawajes Mandal, Victor Sanchez, Koushik Mondal, Katherine Jensen, Anat Galor   +9 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

New Developments in Ocular Surface Squamous Neoplasia

, 2014
Ocular surface squamous neoplasia originates from conjunctiva epithelium and covers a broad spectrum of disease ranging from dysplasia to squamous cell carcinoma. Clinical features may vary from case to case.
Ayşe Yağcı, Yağcı A.
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Managing ocular surface disease: a common sense approach

, 2017
Many diseases can cause ocular surface disorders. The poster on pages 50–51 provides an overview of the most common diseases, and other articles in this issue focus on the management of individual diseases. In this article, the authors offer a systematic
Hon Shing Ong, John KG Dart
core  

Modification of the technique for detection and follow-up of diseases of the anterior ocular segment using the conjunctival autofluorescence method [PDF]

, 2019
Every person is in constant interaction with the environmental factors, with the sun being the highest energy source. The electromagnetic spectrum includes rays of different wavelengths, with shortwave ultraviolet rays being an invisible, potential ...
Neshkinski, Evgeni; Medical University of Varna, Radeva, Mladena; Medical University of Varna, Grupcheva, Christina; Medical University of Varna, Andreev, Jordan; Medical University of Varna, Boyadzhieva, Mariya; Medical University of Varna   +4 more
core   +7 more sources

Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders

, 2022
Substance P (SP) is a tachykinin expressed by various cells in the nervous and immune systems. SP is predominantly released by neurons and exerts its biological and immunological effects through the neurokinin receptors, primarily the neurokinin-1 ...
Musayeva A., Chen, Yihe, Dana R., Naderi A., Singh R. B., Cho W., Dohlman, Thomas H., Ferrari, Giulio, Cho, Wonkyung, Ortiz G., Dana, Reza, Ferrari G., Naderi, Amirreza, Musayeva, Aytan, Singh, Rohan Bir, Dohlman T. H., Chen Y., Ortiz, Gustavo, Aytan Musayeva, Rohan Bir Singh, Reza Dana, Amirreza Naderi, Giulio Ferrari, Yihe Chen, Gustavo Ortiz, Thomas H. Dohlman, Wonkyung Cho   +26 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Discriminative performance of ocular surface staining and lid wiper epitheliopathy in dry eye disease: an investigator-masked, prospective registry-based, diagnostic accuracy study.

Purpose: To evaluate the diagnostic performance of corneal and conjunctival staining, and lid wiper epitheliopathy (LWE) in detecting dry eye disease, as defined by the global consensus Tear Film and Ocular Surface Society Dry Eye Workshop II (TFOS ...
Power, Barry, Craig, Jennifer P, Xue, Ally L, Wang, Michael TM   +3 more
core   +1 more source