Results 91 to 100 of about 8,353,130 (346)

Enrichment protocols for human conjunctival extracellular vesicles and their characterization

Scientific Reports
The understanding of the role played by extracellular vesicles (EVs) in different tissues has improved significantly in the last years, but remains limited concerning the conjunctiva, a complex eye tissue whose role is pivotal for corneal protection ...
Ismael Romero-Castillo, Antonio López-García, Yolanda Diebold, Laura García-Posadas   +3 more
doaj   +1 more source

Ocular Surface Infection and Antimicrobials

Antibiotics, 2022
Infection of the ocular surface can have devastating consequences if not appropriately treated with antimicrobials at an early stage [...]
Dutta, D, Stapleton, F, Willcox, M
openaire   +4 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Relationships between ocular surface sphingomyelinases, Meibum and Tear Sphingolipids, and clinical parameters of meibomian gland dysfunction

, 2022
Sphingolipids (SPL) are a class of lipid molecules that play important functional and structural roles in our body and are a component of meibum. Sphingomyelinases (SMases) are key enzymes in sphingolipid metabolism that hydrolyze sphingomyelin (SM) and ...
Mondal, Koushik, Mandal, Nawajes, Galor, Anat, Jensen, Katherine, Sanchez, Victor   +4 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Non-traumatic bilateral corneal flap dislocation 20 years after LASIK

BMC Ophthalmology
Backgroud This report describes a case of late non-traumatic dislocation of bilateral corneal flaps, occurring 20 years after LASIK surgery. Case presentation A 52-year-old woman underwent LASIK surgery on both eyes 20 years ago.
Dakun Ren, Xiangrong Xie, Xingtong Wang, Xuming Guo   +3 more
doaj   +1 more source

Ageing and ocular surface immunity [PDF]

British Journal of Ophthalmology, 2016
The prevalence of ocular surface immunopathologies is enhanced in the elderly. This increased prevalence has been attributed to age-related dysregulation of innate and adaptive immune system responses. Age-related changes in ocular surface immunity have similar and distinct characteristics to those changes seen in other mucosal tissues.
Alireza, Mashaghi, Jiaxu, Hong, Sunil K, Chauhan, Reza, Dana   +3 more
openaire   +2 more sources

Exploring topical anti-glaucoma medication effects on the ocular surface in the context of the current understanding of dry eye

, 2018
PURPOSE:To assess tear film parameters, ocular surface characteristics, and dry eye symptomology in patients receiving topical anti-glaucoma medications.
Wong, Aaron BC, Wang, Michael, Aaron B.C. Wong, Jennifer P. Craig, Liu, Kevin, Kevin Liu, Danesh-Meyer, Helen, Michael T.M. Wang, Zak J. Prime, Prime, Zak J, Craig, Jennifer, Helen V. Danesh-Meyer   +11 more
core   +1 more source

Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions [PDF]

, 2021
Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy (AAK).
Ashery-Padan, R.,, Lagali, N, Ferrari, Stefano, Latta, Lorenz, Daniels, J., Aberdam, D, Figueiredo, F. C.,, Solá, Susana, Latta, L., Xapelli, Sara, Ashery-Padan, R, Lagali, Neil, Ferrari, S.,, Xapelli, S., Daniels, J, Collinson, J. M., Szentmary, N., Shalom-Feuerstein, R., Aberdam, D.,, Xapelli, S, Daniels, J.,, Solá, S, Ferrari, S., Collinson, JM, Szentmáry, N, Sola, S., Collinson, Jon, Xapelli, S.,, Shalom-Feuerstein, R, Latta, L.,, Lako, M., Szentmary, N.,, Lako, M, Ashery-Padan, R., Shalom-Feuerstein, R.,, Ferrari, S, Lagali, N., Figueiredo, FC, Sola, S.,, Figueiredo, F. C., Collinson, J. M.,, Latta, L, Lako, M.,, Lagali, Neil,, Aberdam, D.   +44 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source