Results 81 to 90 of about 4,998,430 (314)

Clinical Correlations of Novel Autoantibodies in Patients with Dry Eye

Journal of Immunology Research, 2019
Background. Diagnostic criteria for Sjögren’s syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications.
Sezen Karakus, Alan N. Baer, Esen K. Akpek   +2 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Common and Important ocular surface conditions

, 2017
Poster of common and important ocular surface ...
Jeremy Hoffman, Matthew Burton
core  

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Topical Chemotherapy for Ocular Surface Squamous Neoplasia

, 2022
Treatment for ocular surface squamous neoplasia (OSSN) has traditionally consisted of surgical excision; however, recent advances have poised several chemotherapeutic agents as viable alternatives to surgical treatment. These topical chemotherapies offer
Alvarez, Osmel P., Galor, Anat, Karp, Carol L., AlBayyat, Ghada, Osmel P. Alvarez, Ghada AlBayyat, Anat Galor, Carol L. Karp   +7 more
core   +1 more source

Analysis of Cancer Stromal Reaction Using an O-ring Co-culture Assay

Bio-Protocol, 2017
We have developed a 2D heterotypic co-culture technique between fibroblasts and cancer cells that enables the study of the stromal reaction. For such, stromal cells are seeded and cultured immediately around a tumour cell line, and the cells establish ...
Vivien Coulson-Thomas
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Long-Term Clinical Outcomes of nDSAEK and Machine Learning-Based Prediction of Graft Survival in Corneal Endothelial Decompensation

Clinical Ophthalmology
Yuan Lin,1– 6,* Yiming Hu,7,* Zhiwen Xie,1– 6,* Xie Fang,1– 6 Shunrong Luo,1– 6 Xianwen Xiao,1– 6 Zhirong Lin,1– 6 Huping Wu1– 6 1Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, People’s ...
Lin Y, Hu Y, Xie Z, Fang X, Luo S, Xiao X, Lin Z, Wu H   +7 more
doaj  

Advancing vision care in children – bridging science, policy, and practice

BMC Pediatrics
Pediatric vision health is a cornerstone of child development, learning, and social well-being. This editorial synthesizes current advances, challenges, and emerging frontiers in childhood vision care as reflected in this collection, emphasizing equity ...
Bharat Gurnani, Dipesh Patel
doaj   +1 more source