Results 71 to 80 of about 4,998,430 (314)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

TFOS lifestyle. Impact of cosmetics on the ocular surface

, 2023
In this report the use of eye cosmetic products and procedures and how this represents a lifestyle challenge that may exacerbate or promote the development of ocular surface and adnexal disease is discussed.
Markoulli M., Murthy R., McGee S. R., da Costa A. X., Del Duca E., Lazreg S., Ng A., Sullivan D. A., Narang P., Shen J., O'Dell L., Doll T., Roos J., Nistico S., Grupcheva C. N., Liu S. -H., da Costa, Alexandre X., Grupcheva, Christina N., McGee, Selina R., Murthy, Rachna, O'Dell, Leslie, Markoulli, Maria, Doll, Tracy, O’Dell, Leslie, Narang, Purvasha, Ng, Alison, Nistico, Steven, Roos, Jonathan, Lazreg, Sihem, Sullivan, David A., Liu, Su-Hsun, Shen, Joanne, Del Duca, Ester   +32 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Preservatives and ocular surface disease: a review

Ocular surface disease (OSD) is a complex condition that can cause a range of symptoms (eg, dryness, irritation, and pain) and can significantly impact the quality of life of affected individuals.
Messmer, Elisabeth M., Galor, Anat, Radcliffe, Nathan M., Baudouin, Christophe, Rapuano, Christopher J., Kahook, Malik Y.   +5 more
core   +1 more source

Immunoregulation on the Ocular Surface: 2nd Cullen Symposium

, 2009
A one-day symposium with 20 invited participants was held to review current knowledge regarding immunoregulation in the ocular surface and cornea. The program consisted of 11 lectures on various aspects of ocular and systemic immunoregulation, followed ...
Pflugfelder, Stephen C, The Symposium Participants, Stern, Michael E   +2 more
core   +1 more source

Modulation of corneal sensory processing and pain responses by dry eye and corneal wounding

Frontiers in Cellular Neuroscience
BackgroundDry eye disease (DED) is a multifactorial disorder of the ocular surface in which tear film instability, epithelial barrier disruption, and neurosensory dysfunction contribute to symptom generation.
Ebru Yaman, Yangluowa Qu, Kaylin C. Arpaia, Fairouz Elsaeidi, Uma Lakshmi Balakrishnan, Lance He, Henry Skrehot, Jehan Alam, Rui Chen, Mary Ann Stepp, Cintia S. de Paiva, Stephen C. Pflugfelder   +11 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease

Journal of Ophthalmology, 2017
Purpose. To evaluate the efficacy of self-retained cryopreserved amniotic membrane (CAM) in promoting corneal nerve regeneration and improving corneal sensitivity in dry eye disease (DED). Methods.
Thomas John, Sean Tighe, Hosam Sheha, Pedram Hamrah, Zeina M. Salem, Anny M. S. Cheng, Ming X. Wang, Nathan D. Rock   +7 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source