Results 61 to 70 of about 4,998,430 (314)

Non-traumatic bilateral corneal flap dislocation 20 years after LASIK

BMC Ophthalmology
Backgroud This report describes a case of late non-traumatic dislocation of bilateral corneal flaps, occurring 20 years after LASIK surgery. Case presentation A 52-year-old woman underwent LASIK surgery on both eyes 20 years ago.
Dakun Ren, Xiangrong Xie, Xingtong Wang, Xuming Guo   +3 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Small fiber neuropathy in the cornea of Covid-19 patients associated with the generation of ocular surface disease

, 2022
[Purpose]: To describe the association between Sars-CoV-2 infection and small fiber neuropathy in the cornea identified by in vivo corneal confocal microscopy.[Methods]: Twenty-three patients who had overcome COVID-19 were recruited to this observational
Lozano Sanroma, J., Queiruga Piñeiro, J., Quirós Fernández, Luis Manuel, Alcalde Domínguez, Eugenio Ignacio, Barros, A., Fernández-Vega Cueto-Felgueroso, Luis, Alfonso Sánchez, José Fernando, Gallar, J., Merayo Lloves, Jesús, Juan Queiruga-Piñeiro, Gallar, Juana, Juana Gallar, Queiruga-Piñeiro, Juan, Lozano-Sanroma, Javier, Quirós, Luis M., Ignacio Alcalde, Luis M. Quirós, José F. Alfonso, Alfonso, José F., Jesús Merayo-Lloves, Javier Lozano-Sanroma, Merayo-Lloves, Jesús, Fernández-Vega Cueto, Luis, Alcalde, Javier, Luis Fernández-Vega Cueto, Alberto Barros, Barros, Alberto   +26 more
core   +1 more source

Corneal Subbasal Nerve Recovery in an Acute Case of Ultraviolet Keratitis Treated with Autologous Serum Eye Drops

Journal of Ophthalmology, 2018
Purpose. To report degeneration of subbasal corneal nerves and the subsequent neuroregeneration in a case of acute ultraviolet (UV) keratitis, treated with autologous serum eye drops. Methods. Case report. Results.
Farshad Abedi, Pedram Hamrah
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Antioxidant Defenses in the ocular surface [PDF]

The Ocular Surface, 2009
The human eye is subjected constantly to oxidative stress due to daily exposure to sunlight, high metabolic activities, and oxygen tension. Reactive oxygen species generated from environmental insults and pathological conditions render the human eye particularly vulnerable to oxidative damage.
Ying, Chen, Gaurav, Mehta, Vasilis, Vasiliou   +2 more
openaire   +2 more sources

Chronic inflammation as a proposed risk factor for ocular surface squamous neoplasia

Chronic inflammation is a predisposing factor for metaplastic changes and ultimately dysplasia. We describe cases of OSSN occurring in the setting of chronic ocular surface inflammation.
Theotoka, Despoina, De Arrigunaga, Sofia, Galor, Anat, Karp, Carol L., Dubovy, Sander, Friehmann, Asaf, Camacho, Matthew, Wall, Sarah   +7 more
core   +1 more source

Corrigendum to

The authors would like to add new affiliations for Dr. Giulio Ferrari as follows. 1. IRCCS San Raffaele Scientific Institute, Division of Neuroscience, Cornea and Ocular Surface Disease Unit, Eye Repair Lab, Milan, Italy2.
Naroo, S. A., Rocha, E. M., Tong, L., Na, Kyung-Sun, Galor, Anat, Gupta, P. K., Wang, M. T. M., Craig, Jennifer P, Britten-Jones, Alexis Ceecee, Merayo-Lloves, Jesus, Feng, Yun, Goldblum, David, Britten Jones, A. C., Feng, Y., Na, K. S., Nichols, Kelly K, Gupta, Preeya K, Galor, A., Ferrari, Giulio, Wang, Michael T M, Rocha, Eduardo M, Naroo, Shehzad A, Tong, Louis, Goldblum, D., Ferrari, G., Nichols, K. K., Merayo Lloves, Jesús, Craig, J. P., Goldblum D., Wang M. T. M., Tong L., Naroo S. A., Nichols K. K., Galor A., Ferrari G., Rocha E. M., Britten-Jones A. C., Feng Y., Craig J. P., Merayo-Lloves J., Na K. -S., Gupta P. K.   +41 more
core   +2 more sources

NF-κB/IL-6 axis drives impaired corneal wound healing in aqueous-deficient dry eye

Frontiers in Immunology
Dry eye disease (DED) commonly leads to compromised corneal epithelial integrity and chronic ocular surface inflammation; however, the precise molecular mechanisms underlying impaired corneal healing remain incompletely understood.
Cuipei Lin, Cuipei Lin, Jiaxin Wu, Jiaxin Wu, Yuxin Jing, Yuxin Jing, Jingbin Xie, Jingbin Xie, Jiayan Xiang, Jiayan Xiang, Qiwei Fan, Jiangman Liu, Jingheng Du, Xiukui Tan, Zhudan Zhuang, Yunxia Xue, Ting Fu, Jun Liu, Jun Liu, Zhijie Li, Zhijie Li   +20 more
doaj   +1 more source