Results 41 to 50 of about 4,746,381 (313)

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The use of high resolution optical coherence tomography (HR-OCT) in the diagnosis of ocular surface masqueraders

, 2022
Ocular surface masqueraders encompass any ocular surface lesion masquerading as another ocular surface lesion. High resolution optical coherence tomography (HR-OCT) has emerged as an adjunctive tool to clinical acumen. This study's purpose is to evaluate
Sander, Dubovy L, Theotoka, Despoina, Sripawadkul, Wathanee, Galor, Anat, Khzam, Rayan Abou, Tang, Vincent, Karp, Carol L, Wall, Sarah   +7 more
core   +1 more source

Efficacy of epidermal growth factor in suppressing inflammation and proliferation in pterygial fibroblasts through interactions with microenvironmental M1 macrophages

Scientific Reports
The protein epidermal growth factor (EGF), which plays a crucial role in promoting cell proliferation and survival, has recently demonstrated potential in reducing inflammation.
Soo Jin Lee, Ahra Koh, Seung Hyeun Lee, Kyoung Woo Kim   +3 more
doaj   +1 more source

Effects of Sodium Hyaluronate Eye Drops With or Without Preservatives on Ocular Surface Bacterial Microbiota

Frontiers in Medicine, 2022
PurposeThis study aimed to determine the composition and diversity of bacterial communities on the ocular surface before and after the intervention with sodium hyaluronate eye drops (with or without preservatives) using 16S rRNA gene amplicon sequencing ...
Yanlin Zhong, Yanlin Zhong, Xie Fang, Xie Fang, Xuemei Wang, Xuemei Wang, Yu-An Lin, Yu-An Lin, Huping Wu, Huping Wu, Cheng Li, Cheng Li   +11 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Corneal lymphangiogenesis facilitates ocular surface inflammation and cell trafficking in dry eye disease

, 2018
PURPOSE: While the normal cornea has limited innervation by the lymphatic system, chronic immune-inflammatory disorders such as dry eye (DE) can induce lymphangiogenesis in the ocular surface.
노혜미, 김소영, 여아름, 최은영, 지용우, 이형근, 강현구   +6 more
core   +1 more source

Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders

, 2022
Substance P (SP) is a tachykinin expressed by various cells in the nervous and immune systems. SP is predominantly released by neurons and exerts its biological and immunological effects through the neurokinin receptors, primarily the neurokinin-1 ...
Ortiz, Gustavo, Dohlman, Thomas H., Musayeva, Aytan, Dana, Reza, Cho, Wonkyung, Chen, Yihe, Naderi, Amirreza, Ferrari, Giulio, Singh, Rohan Bir   +8 more
core   +1 more source

Is dry eye disease the same in young and old patients? A narrative review of the literature

BMC Ophthalmology, 2022
Advanced age is one of the most evident risk factors for dry eye disease (DED), with male/female sex, chronic drug consumption, and prolonged device use.
Stefano Barabino
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Ectoine, from a Natural Bacteria Protectant to a New Treatment of Dry Eye Disease

Pharmaceutics
Ectoine, a novel natural osmoprotectant, protects bacteria living in extreme environments. This study aimed to explore the therapeutic effect of ectoine for dry eye disease. An experimental dry eye model was created in C57BL/6 mice exposed to desiccating
Xin Chen, Na Lin, Jin-Miao Li, Haixia Liu, Anmar Abu-Romman, Ebru Yaman, Fang Bian, Cintia S. de Paiva, Stephen C. Pflugfelder, De-Quan Li   +9 more
doaj   +1 more source