Results 101 to 110 of about 8,353,130 (346)

Cooperative role of MDSCs and Tregs in alum-induced alloimmune tolerance in corneal transplantation

Scientific Reports
Alum, a widely used adjuvant, has recently been recognized for its capacity to modulate immune responses beyond classical activation. In this study, we investigated whether alum-induced expansion of myeloid-derived suppressor cells (MDSCs) and their ...
Lifang Li, Yuping Han, Xiangrong Xie, Dakun Ren, Ying Zhang, Shaofeng Hao, Xuming Guo   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Corrigendum to

The authors would like to add new affiliations for Dr. Giulio Ferrari as follows. 1. IRCCS San Raffaele Scientific Institute, Division of Neuroscience, Cornea and Ocular Surface Disease Unit, Eye Repair Lab, Milan, Italy2.
Naroo, S. A., Rocha, E. M., Tong, L., Na, Kyung-Sun, Galor, Anat, Gupta, P. K., Wang, M. T. M., Craig, Jennifer P, Britten-Jones, Alexis Ceecee, Merayo-Lloves, Jesus, Feng, Yun, Goldblum, David, Britten Jones, A. C., Feng, Y., Na, K. S., Nichols, Kelly K, Gupta, Preeya K, Galor, A., Ferrari, Giulio, Wang, Michael T M, Rocha, Eduardo M, Naroo, Shehzad A, Tong, Louis, Goldblum, D., Ferrari, G., Nichols, K. K., Merayo Lloves, Jesús, Craig, J. P.   +27 more
core   +2 more sources

Corneal Subbasal Nerve Recovery in an Acute Case of Ultraviolet Keratitis Treated with Autologous Serum Eye Drops

Journal of Ophthalmology, 2018
Purpose. To report degeneration of subbasal corneal nerves and the subsequent neuroregeneration in a case of acute ultraviolet (UV) keratitis, treated with autologous serum eye drops. Methods. Case report. Results.
Farshad Abedi, Pedram Hamrah
doaj   +1 more source

Innate immunity of the ocular surface

Brain Research Bulletin, 2010
The ocular surface epithelium serves a critical function as the defensive front line of the innate immune system. While the detection of microbes is arguably its most important task, an exaggerated host defense reaction to endogenous bacterial flora may initiate and perpetuate inflammatory mucosal responses.
Shigeru, Kinoshita, Mayumi, Ueta
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Tumors of the ocular surface: A review

Indian Journal of Ophthalmology, 2015
Tumors of the Ocular Surface clinically manifest with a very wide spectrum and include several forms of epithelial, stromal, caruncular, and secondary tumors. As a group, these tumors are seen commonly in the clinical practice of a comprehensive ophthalmologist, cornea specialist, and an ocular oncologist.
Santosh G Honavar, Fairooz P Manjandavida   +1 more
openaire   +3 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

NF-κB/IL-6 axis drives impaired corneal wound healing in aqueous-deficient dry eye

Frontiers in Immunology
Dry eye disease (DED) commonly leads to compromised corneal epithelial integrity and chronic ocular surface inflammation; however, the precise molecular mechanisms underlying impaired corneal healing remain incompletely understood.
Cuipei Lin, Cuipei Lin, Jiaxin Wu, Jiaxin Wu, Yuxin Jing, Yuxin Jing, Jingbin Xie, Jingbin Xie, Jiayan Xiang, Jiayan Xiang, Qiwei Fan, Jiangman Liu, Jingheng Du, Xiukui Tan, Zhudan Zhuang, Yunxia Xue, Ting Fu, Jun Liu, Jun Liu, Zhijie Li, Zhijie Li   +20 more
doaj   +1 more source

Chronic inflammation as a proposed risk factor for ocular surface squamous neoplasia

Chronic inflammation is a predisposing factor for metaplastic changes and ultimately dysplasia. We describe cases of OSSN occurring in the setting of chronic ocular surface inflammation.
Theotoka, Despoina, De Arrigunaga, Sofia, Galor, Anat, Karp, Carol L., Dubovy, Sander, Friehmann, Asaf, Camacho, Matthew, Wall, Sarah   +7 more
core   +1 more source