Results 101 to 110 of about 134,535 (267)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Imaging-based assessment of corneal graft rejection after penetrating keratoplasty: insights from confocal microscopy and anterior chamber analysis

Frontiers in Medicine
ObjectiveThis study aimed to explore the distribution of rejection and visual changes after optical and therapeutic penetrating keratoplasty (PKP) in Southeastern China.MethodsThis retrospective study included 104 patients who underwent either optical or
Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Miaomiao Liu, Miaomiao Liu, Miaomiao Liu, Miaomiao Liu, Miaomiao Liu, Miaomiao Liu, Hanqiao Li, Hanqiao Li, Hanqiao Li, Hanqiao Li, Hanqiao Li, Hanqiao Li, Xie Fang, Xie Fang, Xie Fang, Xie Fang, Xie Fang, Xie Fang, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Shunrong Luo, Shunrong Luo, Shunrong Luo, Shunrong Luo, Shunrong Luo, Shunrong Luo, Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Huping Wu   +47 more
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Acute retinal necrosis presenting exudative retinal detachment: a case report

Frontiers in Medicine
BackgroundAcute retinal necrosis (ARN) is a severe, rapidly progressive viral retinitis that is commonly complicated by rhegmatogenous retinal detachment in its late stage.
Han Wang, Ying Zhu, Ai Xuan Cheng, Chao Zhang   +3 more
doaj   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Impact of inflammasomes on the ocular surface

Current Opinion in Allergy & Clinical Immunology
Purpose of review The ocular surface is prone to inflammation due to exposure to environmental irritants and pathogens. Inflammasomes are intracellular, multiprotein complexes that communicate potentially dangerous signals to the immune system.
Stinnett, Gwen S., Kuo, Chuan-Hui, Ono, Santa J.   +2 more
openaire   +2 more sources

Ocular surface leproma

Journal of Postgraduate Medicine, 2018
Ram, J, Kakkar, N, Gupta, G, Gupta, PC
openaire   +2 more sources

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, Accepted Article.
Objective VEXAS syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures. A VEXAS‐specific disease activity index (DAI) is an essential tool for reliably capturing changes in disease ...
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source