Results 11 to 20 of about 171,697 (302)

Possible Strategies to Mitigate Placebo or Vehicle Response in Dry Eye Disease Trials: A Narrative Review

open access: yesOphthalmology and Therapy, 2023
Many candidate drugs for dry eye disease (DED) have been assessed over the years in pursuit of demonstrating efficacy in both signs and symptoms. However, patients with DED have very limited treatment options for management of both signs and symptoms of ...
Michela Montecchi-Palmer   +5 more
doaj   +1 more source

Corneal and Epidermal Nerve Quantification in Chemotherapy Induced Peripheral Neuropathy

open access: yesFrontiers in Medicine, 2022
Chemotherapy-induced neurotoxicity is an increasingly recognized clinical issue in oncology. in vivo confocal microscopy (IVCM) of corneal nerves has been successfully used to diagnose peripheral neuropathies, including diabetic neuropathy.
Nilo Riva   +19 more
doaj   +1 more source

Conjunctival T Cell Profile in Allogeneic Hematopoietic Stem Cell Transplant Patients after Instilling Topical Cyclosporine-A 0.1% Cationic Emulsion

open access: yesOphthalmology and Therapy, 2023
Introduction To profile conjunctival T cell populations in allogeneic hematopoietic stem cell transplant (HSCT) patients after instillation of daily topical cyclosporine-A (CsA) 0.1% cationic emulsion (Ikervis), and to evaluate patients’ tolerance to ...
Louis Tong   +10 more
doaj   +1 more source

Conjunctival infiltrates and cytokines in an experimental immune-mediated blepharoconjunctivitis rat model

open access: yesFrontiers in Medicine, 2023
PurposeTo characterize the histopathological and immunological findings of a rat model of allergic blepharoconjunctivitis (BC) and demonstrate its potential utility for the assessment of BC therapies.MethodsSprague–Dawley (SD) rats were immunized with ...
Aihua Hou   +10 more
doaj   +1 more source

A novel pupilloplasty in crescent-shaped suturing pattern for coloboma and traumatic iris defects

open access: yesBMC Ophthalmology, 2023
Objective Purpose To observe the safety and effect of the C-pupilloplasty for the treatment of iris coloboma and traumatic iris defects. Methods A total of 21 cases (21 eyes) with iris coloboma or traumatic iris defects who underwent C-pupilloplasty (a ...
Xiaoming Yao   +8 more
doaj   +1 more source

Ocular surface disease in glaucoma patients on topical medications and its relation to duration of treatment and number of medications

open access: yesJournal of Clinical Ophthalmology and Research, 2022
Background: Topical antiglaucoma medications can alter the tear film and lead to ocular surface disease (OSD). Aim: This study was done to check for the presence of OSD in patients of glaucoma on topical antiglaucoma medications and to analyze the ...
Samruddhi N Chanekar   +2 more
doaj   +1 more source

Surfactant protein D contributes to ocular defense against Pseudomonas aeruginosa in a murine model of dry eye disease. [PDF]

open access: yes, 2013
Dry eye disease can cause ocular surface inflammation that disrupts the corneal epithelial barrier. While dry eye patients are known to have an increased risk of corneal infection, it is not known whether there is a direct causal relationship between ...
Evans, David   +4 more
core   +7 more sources

Ocular surface immune cell diversity in dry eye disease

open access: yesIndian Journal of Ophthalmology, 2023
Dry eye disease (DED) is a multifactorial chronic ocular surface inflammatory condition. Disease severity has been directly related to the immuno-inflammatory status of the ocular surface.
Archana Padmanabhan Nair   +5 more
doaj   +1 more source

Symptoms and signs of conjunctivitis as predictors of disease course in COVID-19 syndrome

open access: yesJournal of Ophthalmic Inflammation and Infection, 2021
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can induce conjunctivitis signs and symptoms. However, limited information is available on their impact on COVID-19 disease phenotype.
Martina Ranzenigo   +4 more
doaj   +1 more source

Impacto da poluição ambiental na superfície ocular de pacientes com síndrome de Sjögren [PDF]

open access: yes, 2018
Purpose: To evaluate the effect of air pollution on the ocular surface of patients with Sjögren's syndrome. Methods: We investigated the ocular surfaces of thirty patients with Sjögren's syndrome and thirty healthy volunteers (control group) living in ...
Berra, Alejandro   +5 more
core   +2 more sources

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