Results 81 to 90 of about 9,432,011 (294)

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Role of high resolution optical coherence tomography in diagnosing ocular surface squamous neoplasia with coexisting ocular surface diseases

, 2017
Coexistence of an ocular surface disease can mask the typical features of ocular surface squamous neoplasia (OSSN). The purpose of this study was to evaluate high resolution optical coherence tomography (HR-OCT) as an adjunct in the detection and ...
Victor L. Perez, Guillermo Amescua, Nanji, Afshan, Sander Dubovy, Galor, Anat, Perez, Victor L, Amescua, Guillermo, Dubovy, Sander, Marwan Atallah, Carol L. Karp, Madhura Joag, Jianhua Wang, Anat Galor, Afshan Nanji, Karp, Carol L, Wang, Jianhua, Atallah, Marwan, Joag, Madhura   +17 more
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study

, 2021
Ibrahim Y Allam,1 Sihem Lazreg,2 Mohamed Shafik Shaheen,1 Mohamed Fahmy Doheim,1 Mai A Mohammed1 1Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 2Cabinet Ophtalmologie, Alger Centre, Algiers ...
Shafik Shaheen M, Allam IY, Doheim MF, Lazreg S, Mohammed MA   +4 more
core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Characterising the ocular surface and tear film in a population-based birth cohort of 45-year old New Zealand men and women

PurposeTo assess the prevalence of dry eye disease, aqueous tear deficiency, meibomian gland dysfunction, and asymptomatic ocular surface disease in a population-based cohort of 45-year-old New Zealand men and women.MethodsThis cross-sectional study of ...
Wilson, Graham A, Craig, Jennifer P, Cheyne, Kirsten, Wang, Michael T M, Ambler, Antony   +4 more
core   +1 more source

Long-Term Clinical Outcomes of nDSAEK and Machine Learning-Based Prediction of Graft Survival in Corneal Endothelial Decompensation

Clinical Ophthalmology
Yuan Lin,1– 6,* Yiming Hu,7,* Zhiwen Xie,1– 6,* Xie Fang,1– 6 Shunrong Luo,1– 6 Xianwen Xiao,1– 6 Zhirong Lin,1– 6 Huping Wu1– 6 1Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, People’s ...
Lin Y, Hu Y, Xie Z, Fang X, Luo S, Xiao X, Lin Z, Wu H   +7 more
doaj  

Profiles, Distribution, and Functions of Gamma Delta T Cells in Ocular Surface Homeostasis and Diseases

Frontiers in Bioscience-Landmark
The ocular surface microenvironment, containing the cornea, conjunctiva, and lacrimal gland, constitutes the mucosal frontline of the eye and houses a myriad of immune cells.
Zhengze Sun, Haolan Ji, Yifan Zhou, Hongyu Duan, Baikai Ma, Hong Qi   +5 more
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Comparison of ocular-surface disease index questionnaire, tearfilm break-up time, and Schirmer tests for the evaluation of the tearfilm in computer users with and without dry-eye symptomatology

Clinical Ophthalmology, 2012
Cihan Ünlü,1 Esra Güney,1 Betül İlkay Sezgin Akçay,1 Gülünay Akçalı,1 Gürkan Erdoğan,1 Hüseyin Bayramlar21Ümraniye Training and Research Hospital ...
Unlu C, Guney E, Akcay BI, Akcali G, Erdogan G, Bayramlar H   +5 more
doaj