Results 61 to 70 of about 9,432,011 (294)

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Dupilumab-associated ocular surface disease: a case report

, 2022
Aims: Australian dermatologists are becoming familiar with prescribing dupilumab since it was listed on the PBS on the 1st March 2021. The presentation, management and long-term sequelae of dupilumab-associated ocular surface disease is discussed as ...
Sander, Christina, O'Bryen, John
core   +1 more source

Corrigendum to

The authors would like to add new affiliations for Dr. Giulio Ferrari as follows. 1. IRCCS San Raffaele Scientific Institute, Division of Neuroscience, Cornea and Ocular Surface Disease Unit, Eye Repair Lab, Milan, Italy2.
Naroo, S. A., Rocha, E. M., Tong, L., Na, Kyung-Sun, Galor, Anat, Gupta, P. K., Wang, M. T. M., Craig, Jennifer P, Britten-Jones, Alexis Ceecee, Merayo-Lloves, Jesus, Feng, Yun, Goldblum, David, Britten Jones, A. C., Feng, Y., Na, K. S., Nichols, Kelly K, Gupta, Preeya K, Galor, A., Ferrari, Giulio, Wang, Michael T M, Rocha, Eduardo M, Naroo, Shehzad A, Tong, Louis, Goldblum, D., Ferrari, G., Nichols, K. K., Merayo Lloves, Jesús, Craig, J. P.   +27 more
core   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Atopic dermatitis and ocular surface disorders: a United States claims-based cross-sectional study

BMC Ophthalmology
Background To estimate the prevalence of ocular surface disorders (OSDs) by atopic dermatitis (AD) status and evaluate healthcare resource utilization (HRU) among patients with AD. Methods Patients (all ages) enrolled in the Optum Clinformatics® database
Penny Asbell, Esen K. Akpek, Joseph F. Merola, Jacob P. Thyssen, Andrea Marcus, Robert Lubwama, Marius Ardeleanu, Debra Sierka   +7 more
doaj   +1 more source

Various therapies for ocular surface diseases [PDF]

Romanian Journal of Ophthalmology, 2018
This paper aims to discuss various therapeutical strategies (corneal cross-linking, amniotic membrane transplantation with or without autologous serum application, medical regenerative therapy) for treating ocular surface diseases according to medical indications, etiology, local and general status of the patient. Besides the evolution and treatment of
Alina, Gheorghe, Ancuţa Teodora, Rosoga, Fildys, Mrini, Iulia, Vărgău, Florentina, Gherghiceanu   +4 more
openaire   +2 more sources

Epidemiological study of ocular trauma in an urban slum population in Delhi, India. [PDF]

, 2008
PURPOSE: To study the epidemiology and clinical profile of victims of ocular trauma in an urban slum population. MATERIALS AND METHODS: This cross-sectional study, conducted on 500 families each in three randomly selected urban slums in Delhi, collected ...
Vats, S, Gupta, SK, Vashist, P, Chandra, M, Gogoi, M, Murthy, GVS   +5 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders

, 2022
Substance P (SP) is a tachykinin expressed by various cells in the nervous and immune systems. SP is predominantly released by neurons and exerts its biological and immunological effects through the neurokinin receptors, primarily the neurokinin-1 ...
Ortiz, Gustavo, Dohlman, Thomas H., Musayeva, Aytan, Dana, Reza, Cho, Wonkyung, Chen, Yihe, Naderi, Amirreza, Ferrari, Giulio, Singh, Rohan Bir   +8 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source