Results 61 to 70 of about 12,597,069 (251)

Comparison of ocular-surface disease index questionnaire, tearfilm break-up time, and Schirmer tests for the evaluation of the tearfilm in computer users with and without dry-eye symptomatology

Clinical Ophthalmology, 2012
Cihan Ünlü,1 Esra Güney,1 Betül İlkay Sezgin Akçay,1 Gülünay Akçalı,1 Gürkan Erdoğan,1 Hüseyin Bayramlar21Ümraniye Training and Research Hospital ...
Unlu C, Guney E, Akcay BI, Akcali G, Erdogan G, Bayramlar H   +5 more
doaj  

The effect of diquafosol on tear film inflammatory markers in patients with dry eye: A noncomparative, open-label, proof-of-concept study

Journal of International Medical Research
Objective To analyze the effect of 3% diquafosol sodium ophthalmic solution on tear film proinflammatory cytokine levels, ocular symptoms, and tear film stability in patients with dry eye disease.
Raymund V Tanchuling, Paula Vivian C Tan, Raymond Nelson C Regalado, Ruben Lim Bon Siong   +3 more
doaj   +1 more source

Comparison of two treatments for dry eye disease after corneal refractive surgery [PDF]

Brazilian Journal of Medical and Biological Research
There are no international or Chinese guidelines for the management of dry eye disease that develops after corneal refractive surgery. Sodium hyaluronate is the first-line therapy for dry eye diseases but is not sufficient to treat severe conditions ...
Yiping Ma, Yukun Yang
doaj   +1 more source

Corneal lymphangiogenesis facilitates ocular surface inflammation and cell trafficking in dry eye disease

, 2018
PURPOSE: While the normal cornea has limited innervation by the lymphatic system, chronic immune-inflammatory disorders such as dry eye (DE) can induce lymphangiogenesis in the ocular surface.
노혜미, 김소영, 여아름, 최은영, 지용우, 이형근, 강현구   +6 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

A cross-sectional study of ocular surface discomfort and corneal nerve dysfunction after paclitaxel treatment for cancer

Scientific Reports, 2021
Ocular surface dysfunction is common in patients receiving anti-cancer drug treatment. The effects of paclitaxel, a neurotoxic chemotherapeutic drug, on ocular surface discomfort associated with dry eye disease was investigated.
Jeremy Chung Bo Chiang, David Goldstein, Terry Trinh, Kimberley Au, Susanna B. Park, Arun V. Krishnan, Maria Markoulli   +6 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Review and analysis of grading scales for ocular surface staining

, 2019
Vital dye staining has been used for over a century to assess the severity of ocular surface disease. However, despite common usage, a universally accepted “gold standard” grading scale does not exist for corneal and conjunctival staining, which can ...
Simpson, T, Begley, Carolyn G, Caffery, B, Chalmers, R, Situ, Ping, Nelson, J D   +5 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source