Results 71 to 80 of about 12,597,069 (251)

Ocular surface assessment and morphological alterations in meibomian glands with meibography in obstructive sleep apnea Syndrome

, 2019
Meeting of the Turkish-Ophthalmology-Society -- 2018 -- Antalya, TURKEYBasoglu, Ozen K/0000-0001-8168-6611Purpose: To evaluate ocular surface and Meibomian glands morphology of patients with obstructive sleep apnea syndrome (OSAS). Materials and methods:
Palamar, Melis, Karaca, Irmak, Yagci, Ayse, Tasbakan, Mehmet Sezai, Basoglu, Ozen K.   +4 more
core   +2 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source

Congenital Aniridia and the Ocular Surface

, 2016
Aniridia is a congenital pan-ocular disorder caused by haplo-insufficiency of Pax6, a crucial gene for proper development of the eye. Aniridia affects a range of eye structures, including the cornea, iris, anterior chamber angle, lens, and fovea.
Fagerholm, Per,, Ihnatko, Robert,, Edén, Ulla, Lagali, Neil, Edén, Ulla,, Ihnatko, Robert, Fagerholm, Per, Lagali, Neil,   +7 more
core   +1 more source

Epidemiological study of ocular trauma in an urban slum population in Delhi, India. [PDF]

, 2008
PURPOSE: To study the epidemiology and clinical profile of victims of ocular trauma in an urban slum population. MATERIALS AND METHODS: This cross-sectional study, conducted on 500 families each in three randomly selected urban slums in Delhi, collected ...
Vats, S, Gupta, SK, Vashist, P, Chandra, M, Gogoi, M, Murthy, GVS   +5 more
core   +1 more source

Dupilumab-associated ocular surface disease: a case report

, 2022
Aims: Australian dermatologists are becoming familiar with prescribing dupilumab since it was listed on the PBS on the 1st March 2021. The presentation, management and long-term sequelae of dupilumab-associated ocular surface disease is discussed as ...
Sander, Christina, O'Bryen, John
core   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Correlation among ocular surface changes and systemic hematologic indexes and disease activity in primary Sjögren’s syndrome: a cross-sectional study

BMC Ophthalmology
Background To explore the relationship among ocular surface changes, systemic hematologic indexes, and disease activity in primary Sjögren’s syndrome patients.
Yan He, Jianing Feng, Wen Shi, Yuerong Ren, Yingyi Liu, Huanmin Kang, Jing Tian, Ying Jie   +7 more
doaj   +1 more source