Results 61 to 70 of about 6,718,311 (305)

Corneal densitometry in Chinese adults with healthy corneas: associations with sex, age, ocular metrics, and optical characteristics

BMC Ophthalmology
Background Standardized corneal densitometry (CD) values in large samples of healthy Chinese individuals are scarce. Therefore, we aimed to determine the standard CD values using a Scheimpflug camera in healthy corneas, investigate the correlations of ...
Jiliang Ning, Siyu Sun, Qiaosi Zhang, Lin Jin, Xiaoyu Liu, Jun Xu, Lijun Zhang   +6 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Pulsed synchrony regulation of intraocular and cerebrospinal fluid pressure: a novel paradigm for glaucoma pathogenesis and treatment

Frontiers in Medicine
Glaucoma, the leading cause of irreversible blindness worldwide, is characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons.
Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Duan-Qing Huang, Duan-Qing Huang, Duan-Qing Huang, Duan-Qing Huang, Duan-Qing Huang, Duan-Qing Huang, Ting-Ting Li, Ting-Ting Li, Ting-Ting Li, Ting-Ting Li, Ting-Ting Li, Ting-Ting Li, Wei Liang, Wei Liang, Wei Liang, Wei Liang, Wei Liang, Wei Liang, Meng Xu, Meng Xu, Meng Xu, Meng Xu, Meng Xu, Meng Xu, Dong-Kan Li, Dong-Kan Li, Dong-Kan Li, Dong-Kan Li, Dong-Kan Li, Dong-Kan Li   +35 more
doaj   +1 more source

Various therapies for ocular surface diseases [PDF]

Romanian Journal of Ophthalmology, 2018
This paper aims to discuss various therapeutical strategies (corneal cross-linking, amniotic membrane transplantation with or without autologous serum application, medical regenerative therapy) for treating ocular surface diseases according to medical indications, etiology, local and general status of the patient. Besides the evolution and treatment of
Alina, Gheorghe, Ancuţa Teodora, Rosoga, Fildys, Mrini, Iulia, Vărgău, Florentina, Gherghiceanu   +4 more
openaire   +2 more sources

The use of high resolution optical coherence tomography (HR-OCT) in the diagnosis of ocular surface masqueraders

, 2022
Ocular surface masqueraders encompass any ocular surface lesion masquerading as another ocular surface lesion. High resolution optical coherence tomography (HR-OCT) has emerged as an adjunctive tool to clinical acumen. This study's purpose is to evaluate
Sander, Dubovy L, Theotoka, Despoina, Sripawadkul, Wathanee, Galor, Anat, Khzam, Rayan Abou, Tang, Vincent, Karp, Carol L, Wall, Sarah   +7 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Case Report: IVCM of corneal chlorpromazine toxicity drug deposits

Frontiers in Medicine
To investigate corneal deposits in a patient undergoing long-term chlorpromazine therapy using in vivo confocal microscopy with the HRT II Rostock Corneal Module.
Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Xie Fang, Xie Fang, Xie Fang, Xie Fang, Xie Fang, Xie Fang, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Shunrong Luo, Shunrong Luo, Shunrong Luo, Shunrong Luo, Shunrong Luo, Shunrong Luo, Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Huping Wu   +35 more
doaj   +1 more source

Treatment of Ocular Surface Disease in Ocular Cicatricial Pemphigoid

Ocular Immunology and Inflammation
While substantial research has focused on systemic immunomodulatory therapy for ocular cicatricial pemphigoid (OCP), limited data exist on managing associated ocular surface disease (OSD). This study evaluates treatments for OCP-related OSD at our institution.We conducted a retrospective analysis of patients diagnosed with cicatrizing conjunctivitis at
Kaleb S, Abbott, Alan G, Palestine, Scott G, Hauswirth, Darren G, Gregory, Jennifer L, Patnaik, Amit K, Reddy   +5 more
openaire   +2 more sources

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source