Results 81 to 90 of about 6,718,311 (305)

Exploring topical anti-glaucoma medication effects on the ocular surface in the context of the current understanding of dry eye

, 2018
PURPOSE:To assess tear film parameters, ocular surface characteristics, and dry eye symptomology in patients receiving topical anti-glaucoma medications.
Wong, Aaron BC, Wang, Michael, Aaron B.C. Wong, Jennifer P. Craig, Liu, Kevin, Kevin Liu, Danesh-Meyer, Helen, Michael T.M. Wang, Zak J. Prime, Prime, Zak J, Craig, Jennifer, Helen V. Danesh-Meyer   +11 more
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Insights and decision-making on surgical triggers of glaucoma-related complications in congenital cataract surgery: a clinical review

Frontiers in Medicine
Glaucoma-related adverse events (GRAE) after congenital cataract surgery severely affect the visual recovery of children and have attracted significant attention in the medical community. This article focuses on the research of its surgical factors.
Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Wei Fan, Wei Fan, Wei Fan, Wei Fan, Wei Fan, Wei Fan, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li   +17 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Intravitreal drug injection for glaucoma: mechanisms, clinical efficacy, and future horizons

Frontiers in Pharmacology
Intravitreal drug injection has emerged as a transformative approach in glaucoma management, overcoming the limitations of traditional treatments such as poor compliance with topical medications and high complication rates of filtration surgery.
Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Peng Shi, Peng Shi, Peng Shi, Peng Shi, Peng Shi, Peng Shi, Dong-Kan Li, Dong-Kan Li, Dong-Kan Li, Dong-Kan Li, Dong-Kan Li, Dong-Kan Li   +17 more
doaj   +1 more source

Estimating household and community transmission of ocular Chlamydia trachomatis. [PDF]

, 2009
INTRODUCTION: Community-wide administration of antibiotics is one arm of a four-pronged strategy in the global initiative to eliminate blindness due to trachoma. The potential impact of more efficient, targeted treatment of infected households depends on
Anthony W Solomon, Muñoz Beatriz, Solomon, AW, Martin J Holland, Manoj Gambhir, Sheila West, Gambhir Manoj, Bailey Robin L., West, S, Basáñez María-Gloria, María-Gloria Basáñez, Bailey, RL, David C W Mabey, Basanez, M-G, Basáñez, María-Gloria, Grassly, NC, Nicholas C Grassly, Munoz, B, Mabey, DCW, Solomon, Anthony W, Gambhir, Manoj, Blake Isobel M., Blake, Isobel M, Solomon Anthony W., Burton, Matthew J, Burton Matthew J., Mabey David C. W., Grassly, Nicholas C, Beatriz Muñoz, Muñoz, Beatriz, Robin L Bailey, Holland, MJ, Bailey, Robin L, West, Sheila, Holland, Martin J, Blake, IM, Gambhir, M, West Sheila, Grassly Nicholas C., Isobel M Blake, Matthew J Burton, Holland Martin J., Mabey, David CW, Burton, MJ   +43 more
core   +2 more sources

The role of sphingolipids in meibomian gland dysfunction and ocular surface inflammation

, 2022
Inflammation occurs in response to tissue injury and invasion of microorganisms and is carried out by the innate and adaptive immune systems, which are regulated by numerous chemokines, cytokines, and lipid mediators.
Mandal, Nawajes, Galor, Anat, Paranjpe, Vikram, Grambergs, Richard   +3 more
core   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Ocular manifestations of systemic diseases in children

, 2023
Knowledge of ocular diseases and understanding of the complex interplay between eye and systemic health have increased over the years. This knowledge is particularly important when caring for our youngest and most vulnerable paediatric patients when ...
Chong, Cheefoong, Dai, Shuan, Webber, Ann L   +2 more
core   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source