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Zeb1 Promotes Odontoblast Differentiation in a Stage-Dependent Manner
Journal of dentistry research, 2021A comprehensive study of odontoblastic differentiation is essential to understand the process of tooth development and to achieve the ability of tooth regeneration in the future.
Y. Xiao+7 more
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S100A4 is expressed in human odontoblasts and odontoblast-like cells
Tissue and Cell, 2022The calcium-binding protein S100A4 has been found in fibroblasts in many tissues. It has been well studied in the regulating process of inflammation and tumor metastasis. However, as a calcium regulating protein, its expression in the dental pulp has not yet been elucidated.
Xue, Cai, Lu, Zhang, Xiaoyan, Wang
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Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation
Journal of Molecular Histology, 2023FAM20C phosphorylates secretory proteins at S-x-E/pS motifs, and previous studies of Fam20C-dificient mice revealed that FAM20C played essential roles in bone and tooth formation. Inactivation of FAM20C in mice led to hypophosphatemia that masks direct effect of FAM20C in these tissues, and consequently the direct role of FAM20C remains unknown.
Kohei Naniwa+7 more
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Stem Cells, 2020
Mouse dental papilla cells (mDPCs) derive from cranial neural crest cells and maintain mesenchymal stem cell characteristics. The differentiation of neural crest cells into odontoblasts is orchestrated by transcription factors regulating the expression ...
Lin YuXiu+7 more
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Mouse dental papilla cells (mDPCs) derive from cranial neural crest cells and maintain mesenchymal stem cell characteristics. The differentiation of neural crest cells into odontoblasts is orchestrated by transcription factors regulating the expression ...
Lin YuXiu+7 more
semanticscholar +1 more source
Midkine Promotes Odontoblast-like Differentiation and Tertiary Dentin Formation
Journal of dentistry research, 2020Autophagy is an intracellular self-degradation process that is essential for tissue development, cell differentiation, and survival. Nevertheless, the role of autophagy in tooth development has not been definitively identified. The goal of this study was
Y.H. Park+6 more
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Odontoblasts in odontogenic tumors
Medical Hypotheses, 2013Odontoblasts are secretory cells displaying epithelial and mesenchymal features, which exist in a monolayer at the interface between the dentin and pulp of a tooth. During embryogenesis, these cells form a dentin shell and throughout life continue to produce dentin while, also acting as sensor cells helping to mediate tooth sensitivity. In this process,
Nadine C. Milos+2 more
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Mitochondria in Odontoblastic Processes [PDF]
THE odontoblastic processes of human dentin are projections of the odontoblast cytoplasm into spaces in the dense collagenous, highly mineralized dentin matrix1. These projections can be up to several mm in length resulting in the cytoplasm being a long distance (2,000–3,000µ) from the odontoblast nucleus.
R.C. Herold, Harold Kaye
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Journal of Oral Biosciences, 2010
Abstract Odontoblasts, well-polarized columnar cells at the periphery of the dental pulp, originate from neural crest cells. They are primarily involved in dentin formation (dentinogenesis) as sites of the synthesis and secretion of collagenous and non-collagenous matrix proteins, and also participate in the directional transport of Ca 2+ from the ...
Masaki Sato+7 more
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Abstract Odontoblasts, well-polarized columnar cells at the periphery of the dental pulp, originate from neural crest cells. They are primarily involved in dentin formation (dentinogenesis) as sites of the synthesis and secretion of collagenous and non-collagenous matrix proteins, and also participate in the directional transport of Ca 2+ from the ...
Masaki Sato+7 more
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Structure and organization of odontoblasts
The Anatomical Record, 1996Differentiation of odontoblasts involves cell-to-cell recognition, contact stabilization involving the formation of attachment specializations, cytoplasmic polarization, development of the protein synthetic and secretory apparatus, and the active transport of mineral ions.
Takahisa Sasaki, Philias R. Garant
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