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Molecular basis of dental sensitivity: The odontoblasts are multisensory cells and express multifunctional ion channels

open access: yesAnnals of Anatomy, 2018
Odontoblasts are the dental pulp cells responsible for the formation of dentin. In addition, accumulating data strongly suggest that they can also function as sensory cells that mediate the early steps of mechanical, thermic, and chemical dental ...
J A Vega
exaly   +2 more sources
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Odontoblast physiology

Experimental Cell Research, 2014
Odontoblasts are post-mitotic cells organized as a layer of palisade cells along the interface between the dental pulp and dentin. They are responsible for the formation of the physiological primary and secondary dentins. They synthesize the organic matrix of type I collagen and actively participate to its mineralization by secreting proteoglycans and ...
openaire   +2 more sources

Odontoblasts in odontogenic tumors

Medical Hypotheses, 2013
Odontoblasts are secretory cells displaying epithelial and mesenchymal features, which exist in a monolayer at the interface between the dentin and pulp of a tooth. During embryogenesis, these cells form a dentin shell and throughout life continue to produce dentin while, also acting as sensor cells helping to mediate tooth sensitivity. In this process,
Nadine C, Milos   +2 more
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Structure and organization of odontoblasts

The Anatomical Record, 1996
Differentiation of odontoblasts involves cell-to-cell recognition, contact stabilization involving the formation of attachment specializations, cytoplasmic polarization, development of the protein synthetic and secretory apparatus, and the active transport of mineral ions.
T, Sasaki, P R, Garant
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The Amazing Odontoblast

Journal of Dental Research, 2013
Odontoblasts are dentin-secreting cells that survive for the whole life of a healthy tooth. Once teeth are completely erupted, odontoblasts transform into a mature stage that allows for their functional conservation for decades, while maintaining the capacity for secondary and reactionary dentin secretion.
E, Couve, R, Osorio, O, Schmachtenberg
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Odontoblast commitment and differentiation

Biochemistry and Cell Biology, 1998
Histological and cytological organization confer specificity to the odontoblasts. These postmitotic, neural crest derived, polarized cells are aligned in a single layer at the periphery of the dental pulp and secrete the organic components of predentin-dentin.
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Nucleoli of human odontoblasts

Archives of Oral Biology, 1972
Abstract Nucleoli of human odontoblasts were studied in smears stained with buffered toluidine blue at pH 5, for the demonstration of RNP-containing structures, including nucleoli. The odontoblasts were obtained from 5 premolars removed for orthodontic reasons.
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Terminal end of the odontoblast process

Journal of Endodontics, 1988
The terminal end of the odontoblast process wasexamined in rat and human molars by scanning electron microscopy on teeth that were surface demineralized and collagenase digested. It was found that in both samples the odontoblast process ended as a dilated sphere at or just below the dentinoenamel junction.
M J, Sigal, R, Chernecky
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Activation of mitophagy in inflamed odontoblasts

Oral Diseases, 2019
AbstractObjectivesMitophagy is an important mitochondrial quality control mechanism. In this study, we investigated the mitochondrial damage and mitophagy occurred in inflammatory human dental pulp and lipopolysaccharide‐stimulated preodontoblasts.Materials and MethodsIn dental pulp tissues and lipopolysaccharide‐stimulated preodontoblasts ...
Fuhua Yang   +6 more
openaire   +2 more sources

Odontoblast: a mechano‐sensory cell

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2008
AbstractOdontoblasts are organized as a single layer of specialized cells responsible for dentine formation and presumably for playing a role in tooth pain transmission. Each cell has an extension running into a dentinal tubule and bathing in the dentinal fluid.
Magloire, Henry   +4 more
openaire   +3 more sources

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