Results 61 to 70 of about 9,236 (227)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Rare Novel Genetic Variants of the OFD1 Gene Associated With a Familial Form and a Sporadic Case of Long Bone Atypical Fractures

Clinical Genetics, EarlyView.
A novel rare variant of the OFD1 gene was identified in a family with dental hypoplasia, facial hypoplasia, and adult‐onset multiple atypical fractures of long bones. Another variant of the OFD1 gene was found in a woman with bisphosphonate‐associated atypical femur fracture.
Marie‐Ève Boisvert, Halim Maaroufi, Rachel Laframboise, Frédéric Fournier, Suzanne N. Morin, Edith Gagnon, Claudia Gagnon, Fabrice Mac‐Way, Mahmoud Rouabhia, Louis‐Georges Ste‐Marie, Arnaud Droit, Jacques P. Brown, Laëtitia Michou   +12 more
wiley   +1 more source

Gelatinases Cleave Dentin Sialoprotein Intracellularly

Frontiers in Physiology, 2020
Dentin sialoprotein (DSP), the NH2-terminal fragment of dentin sialophosphoprotein (DSPP), is essential for dentin formation and further processed into small fragments inside the odontoblasts. Gelatinases, including matrix metalloproteinases 9 (MMP9) and
Xiaohui Gou, Yifan Xue, Huiwen Zheng, Guobin Yang, Shuo Chen, Zhi Chen, Guohua Yuan   +6 more
doaj   +1 more source

Cellular Dynamics and Dentine Bridge Formation Following Direct Pulp Capping With MTA and Biodentine in a Murine Model

International Endodontic Journal, EarlyView.
ABSTRACT Aim Formation of a mineralized dentine bridge is the hallmark of successful direct pulp capping (DPC). Mineral trioxide aggregate (MTA) and Biodentine are widely used capping materials, but in vivo evidence comparing their regenerative potential remains inconclusive. This study used a controlled murine model to compare dentine bridge formation
Amnah Sajdeya, Joshua Milgram, Nurit Kot‐Limon, Itzhak Abramovitz, Amnon Sharir   +4 more
wiley   +1 more source

Evaluasi Apoptosis Sel Odontoblas Akibat Paparan Radiasi Ionisasi

Journal of Dentistry Indonesia, 2013
Ionizing radiation that is commonly used in the treatment of head and neck cancer can result in multiple effects, such as cell death (apoptotic or necrotic) and malignant transformation.
Supriyadi Supriyadi
doaj   +1 more source

Histopathologic Validity and Clinical Reliability of Wolters Classification of Pulpitis: An Exploratory Study

International Endodontic Journal, EarlyView.
ABSTRACT Aim Wolters' classification of pulpitis has been proposed to classify pulpitis into 4 categories (initial, mild, moderate, severe), aiming to guide clinicians to implement the relevant vital endodontic treatment. The main objective of this study was to test the histologic validity and clinical reliability of the Wolters classification ...
Çağla Fatmanur Yılmaz, Emre Barış, Ozlem Ilk, Güven Kayaoğlu   +3 more
wiley   +1 more source

SHED Differentiate into Functional Odontoblasts and Endothelium

, 2010
Studies on mechanisms underlying the differentiation of dental pulp stem cells are critical for the understanding of the biology of odontogenesis and for dental tissue engineering.
NEIVA, K. G., SANTOS, C. F., MACHADO, M. A. A. M., NOER, J. E., SHI, S., SAKAI, V. T., ZHANG, Z., DONG, Z.   +7 more
core   +1 more source

Enzymes, Dentinogenesis and Dental Caries: a Literature Review

eJournal of Oral Maxillofacial Research, 2014
Objectives: Search in PubMed with keywords “enzymes, dentinogenesis, and dental caries” revealed only 4 items, but when combined with “enzymes, osteogenesis, and osteoporosis” as high as 404 items resulted.
Markku Larmas, George K. B. Sándor
doaj   +1 more source

Synergistic Effects of Bacterial Mimetic and Mechanical Stimulation in Dental Pulp Cell Inflammatory Signalling: A Laboratory Investigation

International Endodontic Journal, EarlyView.
ABSTRACT Objectives Mechanical and/or microbial stimuli can prompt extracellular ATP release in many cell types, where it acts as an inflammatory mediator to amplify pain signals and inflammation. This study aimed to investigate the synergistic effects of microbial and/or mechanical stimulation on ATP and cytokine release from dental pulp cells (DPCs ...
Orla M. Dunne, Lorcan P. McGarvey, Imad About, Fionnuala T. Lundy, Ikhlas El‐Karim   +4 more
wiley   +1 more source

Ultrasructure of THe Crown and Root Odontoblasts

, 2003
The ultrastructure of the odontoblast reflects the certain phases that the cell undergoes in their lifecycle. Ultrastructure studies of the odontoblasts have often been carried out using young teeth.
master administrator
core