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Towards an Identification of Odorant Receptors
Journal of Receptor Research, 1993The molecular nature and diversity of receptive sites for odorous molecules is a central unanswered issue in olfaction. Based on the enormous resolving power of the olfactory system, which enables the stereospecific discrimination of numerous compounds at low concentrations specific receptor proteins have been proposed.
H, Breer +4 more
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Ligand specificity of odorant receptors
Journal of Molecular Modeling, 2006Odorant receptors belong to class A of the G protein-coupled receptors (GPCRs) and detect a large number of structurally diverse odorant molecules. A recent structural bioinformatic analysis suggests that structural features are conserved across class A of GPCRs in spite of their low sequence identity.
Khafizov, K. +3 more
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Suppression of Odorant Responses by Odorants in Olfactory Receptor Cells
Science, 1994Odorants activate an inward current in vertebrate olfactory receptor cells. Here it is shown, in receptor cells from the newt, that odorants can also suppress this current, by a mechanism that is distinct from inhibition and adaptation. Suppression provides a simple explanation for two seemingly unrelated phenomena: the anomalously long latency of ...
T, Kurahashi, G, Lowe, G H, Gold
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Structural basis of amine odorant perception by a mammal olfactory receptor
Nature, 2023Lu Guo +25 more
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Odorant receptor genes in humans
Current Opinion in Genetics & Development, 1999The sense of smell is highly sophisticated in vertebrates but Homo sapiens ranks low in olfactory performance when compared to other species - why? Olfaction initiates with the interaction of odorants with specific receptors on the surface of olfactory sensory neurons in the nose.
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Odorant–Receptor Interactions and Odor Percept: A Chemical Perspective
Chemistry & Biodiversity, 2008AbstractReceptor–ligand interaction models are generally based on a ‘lock and key’ concept. How far this holds true for olfactory receptors and odor molecules is currently uncertain. Here, we have investigated the response of a human olfactory receptor, OR1D2, to a broad array of odorants and found that there is no simple, direct correlation between a ...
Annika, Triller +6 more
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Searching for the Ligands of Odorant Receptors
Molecular Neurobiology, 2007Through the sense of smell mammals can detect and discriminate between a large variety of odorants present in the surrounding environment. Odorants bind to a large repertoire of odorant receptors located in the cilia of olfactory sensory neurons of the nose. Each olfactory neuron expresses one single type of odorant receptor, and neurons expressing the
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2016
Until now the odorant receptors are greatly underappreciated. Olfaction is very important for the live of humans and animals, especially animals depend more on olfaction than humans in many function such as to distinguish suitable food, to unfit foodstuff, to avoid dangers, to protect from enemies, to communicate that way, and to find a receptive mate.
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Until now the odorant receptors are greatly underappreciated. Olfaction is very important for the live of humans and animals, especially animals depend more on olfaction than humans in many function such as to distinguish suitable food, to unfit foodstuff, to avoid dangers, to protect from enemies, to communicate that way, and to find a receptive mate.
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Structural basis of odor sensing by insect heteromeric odorant receptors
ScienceMost insects, including human-targeting mosquitoes, detect odors through odorant-activated ion channel complexes consisting of a divergent odorant-binding subunit (OR) and a conserved co-receptor subunit (Orco).
Jiawei Zhao +3 more
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The Role of Drosophila Odorant Receptors in Odor Coding
2006Drosophila melanogaster is a powerful genetic model organism, and a promising model system in olfaction. At the onset of my thesis research, the expression patterns of fly's 62 odorant receptors (ORs) were largely unknown. I set out to understand the rules of connectivity of olfactory sensory neurons and the resulting properties of olfactory circuit ...
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