Results 51 to 60 of about 247,095 (344)

Efficacy and Safety of Alirocumab in Adults With Homozygous Familial Hypercholesterolemia: The ODYSSEY HoFH Trial.

open access: yesJournal of the American College of Cardiology, 2020
BACKGROUND Homozygous familial hypercholesterolemia (HoFH) is characterized by extremely elevated low-density lipoprotein-cholesterol (LDL-C) levels and early onset atherosclerotic cardiovascular disease despite treatment with conventional lipid-lowering
D. Blom   +13 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

The Odyssey's mythological network. [PDF]

open access: yesPLoS ONE, 2018
In this work, we study the mythological network of Odyssey of Homer. We use ordinary statistical quantifiers in order to classify the network as real or fictional. We also introduce an analysis of communities which allows us to see how network properties
Pedro Jeferson Miranda   +2 more
doaj   +1 more source

Review of \u3cem\u3eProfessional Indian: The American Odyssey of Eleazar Williams\u3c/em\u3e by Michael Leroy Oberg [PDF]

open access: yes, 2016
Reviews the book Professional Indian: The American Odyssey of Eleazar Williams (Philadelphia: University of Pennsylvania Press, 2015) by Michael Leroy ...
Andrews, Edward E.
core   +1 more source

Superbubble Origin of Cosmic Rays

open access: yes, 2012
After a hundred years of searching for the origin of cosmic rays, where and how they are made has finally become clear. Here we briefly trace that odyssey through both astronomical observations and cosmic ray measurements.Comment: 5 pages, 3 figures ...
Lingenfelter, Richard E.
core   +1 more source

The Odyssey

open access: yesGreek and Roman Hell, 2019
The Odyssey is literature's grandest evocation of every man's journey through life. In the myths and legends that are retold here, renowned translator Robert Fagles has captured the energy and poetry of Homer's original in a bold, contemporary idiom and ...
S. Butler
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Odyssey of the mind: Social networking in a cyberschool

open access: yesInternational Review of Research in Open and Distributed Learning, 2012
K-12 online learning and cyber charter schools have grown at a tremendous rate over the past decade. At the same time, these online programs have struggled to provide the social spaces where students can interact that K-12 schools are traditionally able ...
Michael K Barbour, Cory Plough
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Impact as Odyssey [PDF]

open access: yes, 2014
Within the context of the UK’s Research Excellence Framework (REF), academic labor is being tagged to ‘impact’: to demonstrable outputs that go beyond academia and benefit “the wider economy and society” (HEFCE, 2009, 13; see also Rogers et al., this ...
Conlon, Deirdre   +3 more
core   +1 more source

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