Results 71 to 80 of about 247,095 (344)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial.
Journal of the American College of Cardiology, 2019 BACKGROUND The ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial compared alirocumab with placebo, added to high-intensity or maximum-tolerated statin treatment, after acute ...
M. Szarek +23 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
Space cowboys odyssey: beyond the Gould Belt
, 2007 We present our new advanced model for population synthesis of close-by cooling NSs. Detailed treatment of the initial spatial distribution of NS progenitors and a detailed ISM structure up to 3 kpc give us an opportunity to discuss the strategy to look ...
A. Cumming +9 more
core +1 more source
Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo [PDF]
, 2017 While the use of bioluminescent proteins for molecular imaging is a powerful technology to further our understanding of complex processes, fluorescent labeling with visible light fluorescent proteins such as GFP and RFP suffers from poor tissue ...
Blyth, Karen +11 more
core +1 more source
Plastidial retrograde modulation of light and hormonal signaling: an odyssey.
New Phytologist, 2021 The transition from an engulfed autonomous unicellular photosynthetic bacterium to a semi-autonomous endosymbiont plastid was accompanied by the transfer of genetic material from the endosymbiont to the nuclear genome of the host, ensued by the ...
Jishan Jiang, K. Dehesh
semanticscholar +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Host-Microbe Interactions in Microgravity: Assessment and Implications
Life, 2014 Spaceflight imposes several unique stresses on biological life that together can have a profound impact on the homeostasis between eukaryotes and their associated microbes.
Jamie S. Foster +2 more
doaj +1 more source
Surfacing undiagnosed disease: consideration, counting and coding
Frontiers in Pediatrics, 2023 The diagnostic odyssey for people living with rare diseases (PLWRD) is often prolonged for myriad reasons including an initial failure to consider rare disease and challenges to systemically and systematically identifying and tracking undiagnosed ...
Megan F. Baxter +9 more
doaj +1 more source
K+/pi+ probes of jet quenching in AA collisions [PDF]
, 2001 Non-abelian energy loss in quark gluon plasma is shown to lead to novel hadron ratio suppression patterns in ultrarelativistic nuclear collisions. We apply recent (GLV) estimates for the gluon radiative energy loss, which increases linearly with the jet ...
Fai, G. +3 more
core +2 more sources