Results 71 to 80 of about 98,650 (241)

Introducción al pensamiento estético de María Zambrano: Algunos lugares de la pintura

Logos, 2003
María Zambrano art critic presents the special space that painting was for her. Transcribing her contemplations, she reveals an appropriate way to enter in the pictures: the poetic reason, which constitutes a new aesthetic based on fidelity to original ...
Cécile Micheron
doaj  

Active Immunotherapy for the Prevention of Alzheimer’s and Parkinson’s Disease

Vaccines
Neurodegenerative diseases (ND) give rise to significant declines in motor, autonomic, behavioral, and cognitive functions. Of these conditions, Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most prevalent, impacting over 55 million ...
Madeline M. Vroom, Jean-Cosme Dodart
doaj   +1 more source

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Odyssey: a semi-automated pipeline for phasing, imputation, and analysis of genome-wide genetic data

BMC Bioinformatics, 2019
Background Genome imputation, admixture resolution and genome-wide association analyses are timely and computationally intensive processes with many composite and requisite steps.
Ryan J. Eller, Sarath C. Janga, Susan Walsh   +2 more
doaj   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Data assimilation of coherent structures in parametric and gridded spaces: an idealized ocean eddy study [PDF]

Nonlinear Processes in Geophysics
Data assimilation (DA) combines observations and model background to estimate the state of geophysical systems. Coherent structures, such as ocean eddies, are localized geophysical features characterized by a small set of properties: position, amplitude,
S. Dealbera, S. Dealbera, S. Raynaud, C. Granero Belinchon, C. Granero Belinchon, B. Boussidi, C. Le Goff, P. Tandeo, P. Tandeo   +8 more
doaj   +1 more source

Odyssey: a public GPU-based code for GRRT

, 2016
<p>Odyssey is a public, GPU-based General Relativistic Radiative Transfer (GRRT) code for computing images and/or spectra in Kerr metric, which described the spacetime aroung a rotating black hole. Implemented in CUDA C/C++, Odyssey is based on the
Yoon, Suk-Jin (5304253), Younsi, Ziri, Younsi, Ziri (5304247), Yun, Kiyun (5304256), Pu, Hung-Yi, Yoon, Suk-Jin, Pu, Hung-Yi (5304250), Yun, Kiyun   +7 more
core   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Awakening from the nightmare: a study of the democratic hero in James Joyce's Ulysses [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Florianópolis ...
Silva, José Célio
core  

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source