Results 1 to 10 of about 1,272,638 (236)

Silver and polystyrene nanoparticles activate oestrogen signalling via cytoplasmic oestrogen receptor [PDF]

Scientific Reports
This study explores the endocrine-disrupting potential of two commonly encountered nanomaterials, nanoplastic and silver nanoparticles (AgNPs). Many environmental pollutants, especially endocrine-disrupting chemicals (EDCs), such as bisphenol, heavy ...
Szymon Adam Lekki-Porębski, Sylwia Męczyńska-Wielgosz, Marcin Kruszewski, Agnieszka Grzelak   +3 more
doaj   +2 more sources

Deciphering the role of classical oestrogen receptor in insulin resistance and type 2 diabetes mellitus: From molecular mechanism to clinical evidence [PDF]

BioImpacts
The biological actions of oestrogen are mediated by the oestrogen receptor α or β (ERα or ERβ), which are members of a broad nuclear receptor superfamily.
Haryati Ahmad Hairi, Nurul Izzah Ibrahim, Muhammad Zulfiqah Sadikan, Putri Ayu Jayusman, Ahmad Nazrun Shuid   +4 more
doaj   +2 more sources

Oestrogen receptor positive breast cancer and its embedded mechanism: breast cancer resistance to conventional drugs and related therapies, a review [PDF]

Open Biology
Traditional medication and alternative therapies have long been used to treat breast cancer. One of the main problems with current treatments is that there is an increase in drug resistance in the cancer cells owing to genetic differences such as ...
Manu Yadav, Ishita Vaishkiar, Ananya Sharma, Akanksha Shukla, Aradhana Mohan, Madhuri Girdhar, Anil Kumar, Tabarak Malik, Anand Mohan   +8 more
doaj   +2 more sources

Low cytoplasmic NUB1 protein exerts hypoxic cell death with poorer prognosis in oestrogen receptor negative breast cancer patients [PDF]

Translational Oncology
Current prognostic biomarkers fall short in stratifying Oestrogen receptor (ER)-negative breast cancer patients regarding tumour progression risk at diagnosis. The role of AIPL1 in activating its tumour suppressor client protein, NEDD8 Ultimate Buster-1 (
Ka-Liong Tan, Syed Haider, Christos E. Zois, Jianting Hu, Helen Turley, Russell Leek, Francesca Buffa, Oreste Acuto, Adrian L. Harris, Francesco Pezzella   +9 more
doaj   +2 more sources

Clarification of oestrogen receptor thresholds and Allred scoring [PDF]

Breast
Tony Yiu Sang Yuen
doaj   +2 more sources

Phytoestrogens by inhibiting the non-classical oestrogen receptor, overcome the adverse effect of bisphenol A on hFOB 1.19 cells [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Since bisphenol A (BPA) induces bone loss and phytoestrogens enhance the osteoblastogenesis by binding to the non-classical and classical oestrogen receptors, respectively, the present study was aimed to observe the osteoprotective effect ...
Zar Chi Thent, Gabriele Ruth Anisah Froemming, Aletza Binti Mohd Ismail, Syed Baharom Syed Ahmad Fuad, Suhaila Muid   +4 more
doaj   +1 more source

Association between oestrogens receptor expressions in breast cancer and comorbidities: a cross-sectional, population-based study. [PDF]

PLoS ONE, 2014
BACKGROUND: Breast cancer with oestrogen receptor expression is common in older women. Several factors, such as age and reproductive hormone exposure, have been associated with oestrogen receptor expression in breast cancer.
Laure de Decker, Mario Campone, Frederique Retornaz, Gilles Berrut, Anastasia Kabeshova, Florence Molinié, Olivier Beauchet   +6 more
doaj   +1 more source

Positive interaction between GPER and β-alanine in the dorsal root ganglion uncovers potential mechanisms: mediating continuous neuronal sensitization and neuroinflammation responses in neuropathic pain

Journal of Neuroinflammation, 2022
Background The pathogenesis of neuropathic pain and the reasons for the prolonged unhealing remain unknown. Increasing evidence suggests that sex oestrogen differences play a role in pain sensitivity, but few studies have focused on the oestrogen ...
Zhenzhen Xu, Wanli Xie, Yiqi Feng, Yanting Wang, Xia Li, Jie Liu, Yue Xiong, Yuyao He, Lu Chen, Guoyang Liu, Qingping Wu   +10 more
doaj   +1 more source

Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells [PDF]

Open Biology, 2016
Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class of genes which do not code for proteins. LncRNA genes are approximately as numerous as protein-coding genes in the human genome.
Chin-Yo Lin, Erica L. Kleinbrink, Fabien Dachet, Juan Cai, Donghong Ju, Amanda Goldstone, Emily J. Wood, Ka Liu, Hui Jia, Anton-Scott Goustin, Mary A. Kosir, Pattaraporn Thepsuwan, Leonard Lipovich   +12 more
doaj   +1 more source

Towards Unravelling the Role of ERα-Targeting miRNAs in the Exosome-Mediated Transferring of the Hormone Resistance

Molecules, 2021
Hormone therapy is one of the most effective breast cancer treatments, however, its application is limited by the progression of hormonal resistance, both primary or acquired.
Olga E. Andreeva, Danila V. Sorokin, Ekaterina I. Mikhaevich, Irina V. Bure, Yuri Y. Shchegolev, Marina V. Nemtsova, Margarita V. Gudkova, Alexander M. Scherbakov, Mikhail A. Krasil’nikov   +8 more
doaj   +1 more source