Results 11 to 20 of about 1,272,638 (236)

G protein-coupled oestrogen receptor 1, oestrogen receptors and androgen receptor in the sand rat (Psammomys obesus) efferent ducts [PDF]

Folia Morphologica, 2020
BACKGROUND: The efferent ducts are mainly involved in the reabsorption of the seminiferous tubular fluid. Testosterone and oestrogens regulate efferent ducts functions via their receptors.
R. Menad, M. Fernini, L. Lakabi, N. Soudani, S. Smaï, X. Bonnet, T. Gernigon-Spychalowicz, E. Moudilou, J.-M. Exbrayat   +8 more
doaj   +2 more sources

Histological detection of oestrogen receptor in human breast carcinomas

, 1980
Histological (immunocytochemical and cytochemical) methods for demonstrating oestrogen receptor within breast-cancer cells gave a positive reaction in 29 (83%) of 35 breast carcinomas.
Cove, D H, Walker, R A, Howell, A; id_orcid   +2 more
core   +11 more sources

Microarray analysis of tamoxifen resistance in breast cancer. [PDF]

, 2009
PhDTamoxifen remains a widely used hormone therapy for pre and postmenopausal women with hormone receptor positive breast cancer in both adjuvant and metastatic disease settings. Resistance to this well tolerated and cost-effective drug limits its use.
Moss, Charlotte
core   +4 more sources

Design and optimization of Oestrogen Receptor PROTACs based on 4-hydroxytamoxifen [PDF]

, 2022
In the last four decades, treatment of oestrogen receptor positive (ER+) breast cancer (BCa), has focused on targeting the estrogenic receptor signaling pathway. This signaling function is pivotal to sustain cell proliferation.
Irene, Espuny, Antoni, Riera, Alicia, Llorente, Roger , Gomis, Guillem, Loren, Craig, Donoghue, Xavier, Verdaguer   +6 more
core   +2 more sources

GPER limits adverse changes to Ca2+ signalling and arrhythmogenic activity in ovariectomised guinea pig cardiomyocytes

Frontiers in Physiology, 2022
Background: The increased risk of post-menopausal women developing abnormalities of heart function emphasises the requirement to understand the effect of declining oestrogen levels on cardiac electrophysiology and structure, and investigate possible ...
Alice J. Francis, Jahn M. Firth, Jose L. Sanchez-Alonso, Julia Gorelik, Kenneth T. MacLeod   +4 more
doaj   +1 more source

GRACE-trial: a randomised active-controlled trial for vulvovaginal atrophy in patients with breast cancer on endocrine therapy – study protocol

BMJ Open, 2023
Introduction Breast cancer is the most common cancer type in women worldwide. Due to hormone receptor positivity in the majority of the breast cancer tumours is endocrine therapy a crucial part in the treatment landscape of breast cancer.
Glenn Vergauwen, Hannelore Denys, Piet Cools, Hans Verstraelen, Koen van de Vijver, Tom Fiers, Liv Veldeman   +6 more
doaj   +1 more source

The surgical effect on overactive bladder symptoms in women with pelvic organ prolapse

Scientific Reports, 2021
This study aimed to explore the effect of pelvic reconstruction surgery on the relation of pelvic organ prolapse (POP) and overactive bladder (OAB) and the impact of preoperative vaginal oestrogen supplement on vaginal tissue.
Ling-Ying Wu, Kuan-Hui Huang, Tsai-Hwa Yang, Hui-Shan Huang, Tzu-Shu Wang, Kuo-Chung Lan, Fei-Chi Chuang   +6 more
doaj   +1 more source

Oestrogen Inhibits Arterial Calcification by Promoting Autophagy

Scientific Reports, 2017
Arterial calcification is a major complication of cardiovascular disease. Oestrogen replacement therapy in postmenopausal women is associated with lower levels of coronary artery calcification, but its mechanism of action remains unclear.
Yi-Qun Peng, Dan Xiong, Xiao Lin, Rong-Rong Cui, Feng Xu, Jia-Yu Zhong, Ting Zhu, Feng Wu, Min-Zhi Mao, Xiao-Bo Liao, Ling-Qing Yuan   +10 more
doaj   +1 more source

Parenteral oestrogen in the treatment of prostate cancer: a systematic review. [PDF]

, 2008
The objectives of this study were to assess the effectiveness and safety of parenteral oestrogen in the treatment of prostate cancer, and to examine any dose relationship. A systematic review was undertaken.
Langley, R. E., Ritchie, G, Abel, P, Norman, G., Langley, RE, Parmar, M. K B, R E Langley, Abel, P., Dean, ME, Hodges, ZC, Sydes, M. R., P Abel, M E Dean, A J Eastwood, G Norman, Norman, G, Z C Hodges, Ritchie, G., Sydes, MR, Hodges, Z. C., Dean, M. E., Eastwood, AJ, M R Sydes, Parmar, MKB, G Ritchie, Eastwood, A. J., M K B Parmar   +26 more
core   +1 more source

SOX2OT Long Noncoding RNA Is Regulated by the UPR in Oestrogen Receptor-Positive Breast Cancer

Sci, 2021
Endoplasmic reticulum (ENR) stress perturbs cell homeostasis and induces the unfolded protein response (UPR). In breast cancer, this process is activated by oestrogen deprivation and is associated with tamoxifen resistance.
Carole Ferraro-Peyret, Marjan E. Askarian-Amiri, Debina Sarkar, Wayne R. Joseph, Herah Hansji, Bruce C. Baguley, Euphemia Y. Leung   +6 more
doaj   +1 more source