Results 81 to 90 of about 1,272,638 (236)

An oestrogen receptor β-selective agonist exerts anti-neoplastic effects in experimental intrahepatic cholangiocarcinoma

, 2012
Background: Cholangiocarcinoma cells over-express oestrogen receptor-beta, which displays anti-proliferative and pro-apoptotic effects. Aim: To evaluate the effects of a newly developed and highly selective oestrogen receptor-beta agonist (KB9520) on ...
Domenico Alvaro, Antonio Benedetti, Elisabet Kallin, Alessia Torrice, Irene Pierantonelli, Stefan Nilsson, Giammarco Fava, Patrik Rhonnstad, GAUDIO, EUGENIO, SEMERARO, ROSSELLA, Chiara Rychlicki, ONORI, PAOLO, S. Nisson, Paolo Onori, Cinzia Candelaresi, Samuele De Minicis, Theresa Apelqvist, FRANCHITTO, Antonio, Laura Agostinelli, GENTILE, RAFFAELE, Marco Marzioni, Rossella Semeraro, Antonio Franchitto, Guido Carpino, ALVARO, Domenico, Stefania Saccomanno, Luciano Trozzi, Eugenio Gaudio, Raffaele Gentile, TORRICE, Alessia   +29 more
core   +2 more sources

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Effect of theophylline on nuclear retention of oestrogen-receptor complexes: correlation with oestrogen responses [PDF]

, 1985
In the ovariectomized adult rat uterine oedema induced by 0.01 and 0.1 μg oestradiol-17β/100 g body weight increased further in the presence of theophylline.
Fierro, C., Steinsapir, J., Alarcón, O., Fuentes, I., Rojas, A. M., Bruzzone Valdés, María Eugenia, White, A., Ampuero, R., González, O., Fuentes, M.   +9 more
core   +1 more source

Hypothalamic and sex-related hormones in migraine

The Journal of Headache and Pain
The hypothalamus and sex hormones are closely linked to primary headache disorders. Migraine is the most prevalent disabling neurological disorder, affecting up to 15% of the global population, with enormous socioeconomic and personal impacts.
Karin Warfvinge, Jacob C. A. Edvinsson, Aida Maddahi, Lars Edvinsson   +3 more
doaj   +1 more source

Immunohistochemical Pattern of Breast Cancer Patients from a Limited Geographical Region of Tamil Nadu, India: A Retrospective Study [PDF]

National Journal of Laboratory Medicine
Introduction: Breast Cancer is the leading cause of cancer incidence worldwide among females, accounting for 11.6% of all cancers, with an estimated mortality rate of 6.9%, ranking fourth according to Global Cancer Observatory (GLOBOCAN) 2022 statistics.
Rajiv Kumar Krishnan, R Vishnusri
doaj   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Oestrogenic and androgenic activity of oxybenzone and methylparaben in vitro

Arhiv za Higijenu Rada i Toksikologiju
Motivated by emerging concerns about health hazards associated with various industrial chemicals, this study investigated the disruption of endocrine system using well established in vitro assays.
Peranić Nikolina, Božičević Lucija, Vrček Ivana Vinković   +2 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Insufficient antibody validation challenges oestrogen receptor beta research

Nature Communications, 2017
A large body of work into the role of oestrogen receptor b (ERb) in breast cancer is contradictory, hindering future progress. Here the authors conduct extensive validation of anti-ERb antibodies , and show that normal and cancerous breast tissue do not ...
Sandra Andersson, Mårten Sundberg, Nusa Pristovsek, Ahmed Ibrahim, Philip Jonsson, Borbala Katona, Carl-Magnus Clausson, Agata Zieba, Margareta Ramström, Ola Söderberg, Cecilia Williams, Anna Asplund   +11 more
doaj   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source