Results 101 to 110 of about 12,593,734 (299)

Working in a 'dementia-friendly' office: Stirling University's Iris Murdoch Building

, 2006
The paper examines the office environment in the context of a university building designed for two quite different purposes – as office accommodation for staff and as an exemplar of ‘dementia-friendly’ design.
McCabe, Louise, Sim, Duncan
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A proposal of method for module commonization in product family (Application of diversity analysis method to servo motors and verification of its effectiveness)

Nihon Kikai Gakkai ronbunshu
A method for both quality improvement and design efficiency is required to meet diversifying customer requirements and human resource development. Especially in the case of production approach with customization, such as in industrial equipment, a design
Naoki INOUE, Kenichi SAGAYAMA, Kenta SUMA, Takashi KOBAYASHI, Kenichi WAKITA, Takehiro NAKAI, Yoshiki MAEDA, Kazuki MASUDA, Fumiaki TSUCHIYA   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Solar-optimum design principles for office buildings

MATEC Web of Conferences, 2017
New concept of passive cooling of buildings is presented in this article.. In order to achieve that, it is planned to define three basic elements of the building concept – shape of building, sun movement and sustainability of the building.
Borodinecs Anatolijs, Sorokins Juris, Bykova Yulia, Nefedova Anna   +3 more
doaj   +1 more source

Office design as a risk factor for disability retirement: A prospective registry study of Norwegian employees. [PDF]

Scand J Work Environ Health, 2021
Nielsen MB, Emberland JS, Knardahl S.
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Integratıng bıophılıc desıgn elements ınto offıce desıgns

Ain Shams Engineering Journal
Biophilic design, in the context of modern interior spaces, focuses on incorporating natural elements and materials to counter the growing disconnect between people and nature. It aims to enhance human well-being, particularly within office environments,
Ahenk Karci Demirkol, Ayşe Kalayci Önaç   +1 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source