Results 101 to 110 of about 660,630 (306)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The Design Requirements of Office Systems
, 1983 Automation of office work constitutes a new growing appl ication of information systems. The original characteri stics of an Office Information System (OIS) in comparison with a conventional information system imply the need for devel opi ng new design ...
PERNICI, BARBARA, BRACCHI, GIAMPIO
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Integratıng bıophılıc desıgn elements ınto offıce desıgns
Ain Shams Engineering JournalBiophilic design, in the context of modern interior spaces, focuses on incorporating natural elements and materials to counter the growing disconnect between people and nature. It aims to enhance human well-being, particularly within office environments,
Ahenk Karci Demirkol +1 more
doaj +1 more source
Office design as a risk factor for disability retirement: A prospective registry study of Norwegian employees. [PDF]
Scand J Work Environ Health, 2021 Nielsen MB, Emberland JS, Knardahl S.
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Working in a 'dementia-friendly' office: Stirling University's Iris Murdoch Building
, 2006 The paper examines the office environment in the context of a university building designed for two quite different purposes – as office accommodation for staff and as an exemplar of ‘dementia-friendly’ design.
McCabe, Louise, Sim, Duncan
core +1 more source
Office Rent Determinants: A Hedonic Panel Analysis [PDF]
It has been frequently observed that office markets are subject to particularly high fluctuations in rents and vacancy levels, thus exposing real estate investors to considerable risk regarding expected future income streams.
Fuerst, Franz
core +1 more source