Results 81 to 90 of about 12,631,699 (241)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Offset-Free Model Predictive Control of the Van De Vusse Reaction

This paper presents the design of the model predictive control (MPC) of the Van de Vusse reaction (VVR) with the state estimation and compares two offset-free reference tracking techniques.
Málik, Róbert, Tárník, Marián, Okienková, Kristína, Vaccari, Marco, Dodek, Martin, Bacci Di Capaci, Riccardo, Paulusová, Jana, Pannocchia, Gabriele   +7 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Velocity control of dynamic positioning vessel based on linear active disturbance rejection controller with environmental disturbance

Journal of Ocean Engineering and Science
The position keeping of a vessel typically can be accomplished through the implementation of a dynamic positioning (DP) system without specifically controlling the vessel velocity.
Ze Li, Ruiyan Gong, Jinhui Jiang, Yiting Wang, Lei Wang   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Experimental Validation of Offset-Free Model-Based Predictive Control in Voltage Source Inverters for Grid Connected and Microgrids Applications

Applied Sciences
This article presents the experimental validation of a model-based predictive control (MPC) strategy for the safe interconnection of voltage source inverters (VSI) with output LC filters for the grid connection of DC energy resources.
Reinier López Ahuar, Dave Figueroa, Juan C. Agüero, César A. Silva   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Validation in diabetic rats of a fully automated insulin delivery system based on impulsive offset-free MPC control.

PLoS ONE
The development of an impulsive automated insulin delivery system (i-AiDS) for type 1 diabetes mellitus aims to provide real-time blood glucose regulation with minimal human intervention.
Jhon E Goez-Mora, Natalia Arbelaez-Córdoba, Norman Balcazar-Morales, Pablo S Rivadeneira   +3 more
doaj   +1 more source