Results 81 to 90 of about 116,340 (302)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Constrained predictive control of a robotic manipulator using quasi-LPV representations

, 2018
In this paper a practical approach to Nonlinear Model Predictive Control (NMPC) of a robotic manipulator subject to nonlinear state constraints is presented, which leads to a successful experimental implementation of the control algorithm.
Cisneros, Pablo S. G., Sridharan, Aadithyan, Werner, Herbert   +2 more
core   +1 more source

Incremental State-Space Model Predictive Control of a Fresnel Solar Collector Field

Energies, 2018
Model predictive control has been demonstrated to be one of the most efficient control techniques for solar power systems. An incremental offset-free state-space Model Predictive Controller (MPC) is developed for the Fresnel collector field located at ...
Eduardo F. Camacho, Antonio J. Gallego, Adolfo J. Sanchez, Manuel Berenguel   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Offset Free Model Predictive Control of an Open Water Reach

, 2014
Model predictive control (MPC) is a powerful tool which is used more and more to managing water systems such as reservoirs over a short-term prediction horizon.
Tian, X. (author), van Overloop, Peter-Jules, Tian, Xin, Aydin, Boran Ekin, Aydin, B.E. (author), van Overloop, P.J.A.T.M. (author)   +5 more
core   +1 more source

A multiple model, state feedback strategy for robust control of non-linear processes

, 2007
The major limitation of reported multiple model approaches is that robustness against process/controller disturbances cannot be addressed for processes consisting of hybrid stable/unstable regimes, or with chaotic dynamics. In this paper, a significantly
Bahri, B., Bahri, P.A., Lee, P., Cameron, I.T., Lee, P.L., Wang, F.Y.   +5 more
core   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Multiloop Integral Controllability Analysis for Nonlinear Multiple-Input Single-Output Processes

, 2017
© 2017 American Chemical Society. The decentralized integral controllability (DIC) for linear/nonlinear square processes implies the existence of stable decentralized controllers with integral actions capable of achieving offset-free control and detuning
Celler, B, Andrey Savkin, Nguyen, H, Savkin, A, Hung Nguyen, Su, S, Yi Zhang, Branko Celler, Zhang, Y, Steven Su   +9 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Adaptive Model Predictive Control for Offset-Free Setpoint Tracking of Nonlinear Processes

, 2020
This thesis presents an overview of model predictive control (MPC) and an improved linear adaptive MPC (AMPC) method for nonlinear process regulation. The beginning introduces the different aspects of MPC from theory to implementation.
Perez, Anthony R.
core