Results 1 to 10 of about 861,121 (278)

Maternal cholesterol deficiency predisposes congenital heart defects risk

Signal Transduction and Targeted Therapy
The relationship between maternal cholesterol deficiency and the risk of congenital heart defects (CHDs) in offspring is not fully understood. In a birth cohort study of 5041 family trios, we found that low maternal cholesterol levels were significantly ...
Yayun Gu, Jimiao Gao, Hong Lv, Yan Zhou, Tao Jiang, Jia Guo, Wanting Ma, Yiwei Cheng, Xia Chi, Qi Xi, Kan Ye, Jiangbo Du, Jiong Li, Cheng Wang, Juncheng Dai, Hongxia Ma, Guangfu Jin, Yuan Lin, Hongbing Shen, Zhibin Hu   +19 more
doaj   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure

Cell Discovery
Androgen exposure (AE) poses a profound health threat to women, yet its transgenerational impacts on male descendants remain unclear. Here, employing a large-scale mother-child cohort, we show that maternal hyperandrogenism predisposes sons to β-cell ...
Yuqing Zhang, Shourui Hu, Shan Han, Congcong Liu, Xiaofan Liang, Yuxuan Li, Zongxuan Lin, Yiming Qin, Chunxuan Geng, Yue Liu, Linlin Cui, Jingmei Hu, Changming Zhang, Zhao Wang, Xin Liu, Jinlong Ma, Zi-Jiang Chen, Han Zhao   +17 more
doaj   +1 more source

Delayed Second Cell Cleavage in Human Early Embryo Is Associated With Adverse Developmental Competence and Pregnancy Outcomes, Even If the Third Cleavage Completes on Time

Maternal-Fetal Medicine
. Objective:. To investigate the impact of the second division timing on pregnancy outcome after in vitro fertilization. Methods:. In this unpaired retrospective study, 16,696 embryos from 6571 patients were analyzed.
Ran Dong, Qing Li, Shuiying Ma, Cheng Li, Haibin Zhao, Lianjie Li, Kai Xu, Hui Zhao, Boyang Liu, Mei Li, Jue Li   +10 more
doaj   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Karyotypic analysis of 62,587 Han Chinese infertile couples undergoing assisted reproductive technology treatments: insights into chromosomal variations

BMC Genomics
Objective This retrospective cytogenetic analysis aimed to characterize karyotypic profiles in a cohort of infertile Han Chinese couples undergoing assisted reproductive technology (ART) interventions. Methods G-banding karyotyping analysis was performed
Shiheng Zhu, Qian Zhang, Mengchun Hu, Yaxuan Zhang, Anmiao Sun, Xuan Gao, Hong Chen, Junhao Yan   +7 more
doaj   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Stage‐Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis

Advanced Science
Spermiogenesis is the committed step of sperm production, during which spermatid cells undergo dramatic morphological transformations and transcriptional silencing.
Tianyu Zhu, Yan Zhu, Xinyi Jiang, Xiangzheng Zhang, Bing Wang, Yu Chen, Yichen Zhao, Yulian Wang, Qi Zhou, Zhongyan Han, Yaling Qi, Mengjiao Luo, Haixia Tu, Bingjie Hao, Mengmeng Gao, Jie Ren, Xin Zhou, Xingyu Zhang, Xu Chen, Haojie Li, Qian Huang, Chenghao Situ, Yueshuai Guo, Hui Zhu, Yan Li, Xuejiang Guo   +25 more
doaj   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway

Cell Communication and Signaling
Background Reduced oocyte quality is a key factor in age-related fertility decline, and there are no effective treatments available. The secretome of mesenchymal stem cells (MSC-sec) contains various bioactive factors and has the potential to improve ...
Jing Zhou, Cheng Li, Xin Mi, Jiali Zhou, Caiyi Chen, Jiayi Ren, Ran Liu, Gang Liu, Zi-Jiang Chen, Yingying Qin, Keliang Wu, Shidou Zhao   +11 more
doaj   +1 more source