Results 41 to 50 of about 911,118 (353)

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science
Testicular organoids (TOs) offer an opportunity to preserve fertility, but current TO protocols are limited by suboptimal maintenance of the organoid structure, meiotic defects, and incomplete in vitro spermatogenesis (IVS). Here, a strategy is developed
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
doaj   +1 more source

Secondary reproductive strategies in Pacific black brant (Branta bernicla nigricans) [PDF]

, 1999
Thesis (M.S.) University of Alaska Fairbanks, 1999Waterfowl are known to use secondary reproductive strategies, both extra-pair copulations and intraspecific brood parasitism, to increase fitness. We used five polymorphic microsatellite loci to determine
Svete, Pamela A.
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

NKAPL facilitates transcription pause-release and bridges elongation to initiation during meiosis exit

Nature Communications
Transcription elongation, especially RNA polymerase II (Pol II) pause-release, is less studied than transcription initiation in regulating gene expression during meiosis.
Zhenlong Kang, Chen Xu, Shuai Lu, Jie Gong, Ruoyu Yan, Gan Luo, Yuanyuan Wang, Qing He, Yifei Wu, Yitong Yan, Baomei Qian, Shenglin Han, Zhiwen Bu, Jinwen Zhang, Xian Xia, Liang Chen, Zhibin Hu, Mingyan Lin, Zheng Sun, Yayun Gu, Lan Ye   +20 more
doaj   +1 more source

Differences in early developmental rate and yolk conversion efficiency in offspring of trout with alternative life histories [PDF]

, 2016
Partial migration, in which some individuals of a population migrate while other individuals remain resident, is generally associated with ontogenetic shifts to better feeding areas or as a response to environmental instability, but its underlying ...
Abbott, Allen, Bachman, Berghe, Berthold, Braun, Brockelman, Brodersen, Burton, Burton, Chapman, Cutts, Cutts, Dodson, Dziminski, Eek, Ege, Einum, Elliott, Fleming, Fleming, Forseth, Grayson, Gross, Imre, Jonsson, Jonsson, Jonsson, Kamler, Killen, Kinnison, Leeuwen, Metcalfe, Monaghan, Morinville, Mousseau, Nakano, O'Neal, Olofsson, Olsson, Olsson, Olsson, Paez, Pakkasmaa, Pulido, Quinn, R Core Team, Reid, Reznick, Roff, Rollinson, Rollinson, Rosenfeld, Régnier, Sandell, Skoglund, Sloman, Steffensen, Stevens, Taborsky, Taylor, Taylor, Thorpe, Wysujack   +63 more
core   +1 more source

Experimental evidence for offspring learning in parent–offspring communication

Proceedings of the Royal Society of London. Series B: Biological Sciences, 2000
The offspring of birds and mammals solicit food from their parents by a combination of movements and vocalizations that have come to be known collectively as 'begging'. Recently, begging has most often been viewed as an honest signal of offspring need. Yet, if offspring learn to adjust their begging efforts to the level that rewards them most, begging ...
H, Kedar, M A, Rodríguez-Gironés, S, Yedvab, D W, Winkler, A, Lotem   +4 more
openaire   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Titanium exposure and gestational diabetes mellitus: associations and potential mediation by perturbation of amino acids in early pregnancy

Environmental Health
Background Several recent studies reported the potential adverse effects of titanium exposure on glucose homeostasis among the non-pregnant population, but the association of titanium exposure with gestational diabetes mellitus (GDM) is scarce.
Yangqian Jiang, Tianyu Sun, Yue Jiang, Xiaoyan Wang, Qi Xi, Yuanyan Dou, Hong Lv, Yuting Peng, Shuxin Xiao, Xin Xu, Cong Liu, Bo Xu, Xiumei Han, Hongxia Ma, Zhibin Hu, Zhonghua Shi, Jiangbo Du, Yuan Lin, China National Birth Cohort (CNBC) Study Group   +18 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

STYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation

Nature Communications
Tubulin-based microtubule is a core component of flagella axoneme and essential for sperm motility and male fertility. Structural components of the axoneme have been well explored.
Yu Chen, Mengjiao Luo, Haixia Tu, Yaling Qi, Yueshuai Guo, Xiangzheng Zhang, Yiqiang Cui, Mengmeng Gao, Xin Zhou, Tianyu Zhu, Hui Zhu, Chenghao Situ, Yan Li, Xuejiang Guo   +13 more
doaj   +1 more source