Results 41 to 50 of about 461,287 (304)

Trigger-day hCG effects on DNA methylation and neurodevelopment in ART offspring

Nature Communications
Assisted reproductive technology influences the epigenetic landscape of offspring, but whether trigger-day pharmacotherapy affects epigenetics and neurodevelopment remains unclear.
Yue Jiang, Xiaoyu Wei, Xianghu Liu, Jun Zhou, Muyi Han, Anqi Zhao, Hong Lv, Yangqian Jiang, Yayun Gu, Cheng Wang, Juncheng Dai, Hongxia Ma, Guangfu Jin, Ran Huo, Qiang Wang, Xuejiang Guo, Hongbing Shen, Yuan Lin, Yuanlin He, Qigang Zhou, Zhibin Hu   +20 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Socioeconomic disparities and health-related parenting practices in shaping early infant neurodevelopment: evidence from a Chinese prospective birth cohort

BMC Pregnancy and Childbirth
Background Few studies have comprehensively examined, within the same population, the roles of both prenatal and postnatal factors in the association between family socioeconomic status (SES) and early infant neurodevelopment. Methods Four thousand seven
Jie Chen, Wanting Huang, Jiayi He, Rui Qin, Hong Lv, Tianyu Sun, Yuanyan Dou, Xin Xu, Cong Liu, Chao Wang, Lei You, Xiumei Han, Bo Xu, Xiaoyu Liu, Kun Zhou, Yangqian Jiang, Jiangbo Du, Guangfu Jin, Hongxia Ma, Yuan Lin, Zhibin Hu, Tao Jiang, For the China National Birth Cohort (CNBC Study Group)   +22 more
doaj   +1 more source

The influence of maternal effects on indirect benefits associated with polyandry [PDF]

, 2010
Despite numerous and diverse theoretical models for the indirect benefits of polyandry, empirical support is mixed. One reason for the difficulty in detecting indirect benefits of polyandry may be that these are subtle and are mediated by environmental ...
House, Clarissa M., House, Clarissa M. (R18735), Clarissa M. House, Bronwyn H. Bleakley, Price, Thomas A.R., Price, Thomas A., Clare E. Stamper, Craig A. Walling, Thomas A. R. Price, Stamper, Clare E., Bleakley, Bronwyn H., Moore, Allen J., Price, Thomas A. R., Allen J. Moore, Walling, Craig A.   +14 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Mesenchymal stem cells promote ovarian reconstruction in mice

Stem Cell Research & Therapy
Background Studies have shown that chemotherapy and radiotherapy can cause premature ovarian failure and loss of fertility in female cancer patients. Ovarian cortex cryopreservation is a good choice to preserve female fertility before cancer treatment ...
Jiazhao Li, Haonan Fan, Wei Liu, Jing Zhang, Yue Xiao, Yue Peng, Weijie Yang, Wenwen Liu, Yuanlin He, Lianju Qin, Xiang Ma, Jing Li   +11 more
doaj   +1 more source

Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice

, 2012
Aims: to determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring.Methods: female C57BL6J mice were fed an obesogenic high fat diet (HF, 45%
Geraldine F Clough, Clough, G.F., Torrens Christopher, Mann, Giovanni E.; id_orcid, Hanson Mark A., Mann Giovanni E., Kimberley D Bruce, Cagampang Felino R. A., Christopher Torrens (114420), Mann, G.E., Ethirajan Priya, Richard C M Siow, Geraldine F. Clough (114433), Byrne Christopher D., Christopher D. Byrne (114429), Siow, Richard C. M.; id_orcid, Felino R. A. Cagampang (114423), Ethirajan, Priya, Cagampang, Felino R. A., Mark A. Hanson (114427), Bruce, K.D., Byrne, Christopher D., Richard C. M. Siow (114425), Giovanni E. Mann (114431), Priya Ethirajan, Mark A Hanson, Kimberley D. Bruce (114422), Bruce Kimberley D., Siow Richard C. M., Christopher D Byrne, Ethirajan, P., Priya Ethirajan (114421), Clough Geraldine F., Torrens, Christopher, Felino R A Cagampang, Giovanni E Mann, Hanson, Mark A., Christopher Torrens, Bruce, Kimberley D., Clough, Geraldine F., Siow, R.C., Cagampang, F.R.   +41 more
core   +1 more source

The generation of live offspring from vitrified oocytes [PDF]

, 2011
Oocyte cryopreservation is extremely beneficial for assisted reproductive technologies, the treatment of infertility and biotechnology and offers a viable alternative to embryo freezing and ovarian grafting approaches for the generation of embryonic stem
Sanchez-Partida, Luis, Sumer, Huseyin, Sumer, H, Kelly, Richard, Lo, Camden, Kelly, RDW, Aharon, R, Moira K. O'Bryan, Kelly Richard D. W., Michael K. Holland, Camden Y. Lo, O'Bryan Moira K., St. John, Justin C., Justin C St John, Camden Y Lo, St John, Justin C., L. Gabriel Sanchez-Partida, Sumner, Huseyin, Sanchez-Partida L. Gabriel, John St., JC, St John, Justin, Sanchez-Partida, L. Gabriel, Richard D W Kelly, Michael K Holland, Moira K O'Bryan, St. John Justin C., Aharon Rotem, Sumer Huseyin, Lo Camden Y., Holland, Michael K., O'Bryan, Moira K., Rotem Aharon, Aharon, Rotem, Justin C. St. John, Holland Michael K., Sanchez-Partida, LG, O'Bryan, Moira, Lo, CY, Holland, MK, Lo, Camden Y., Huseyin Sumer, L Gabriel Sanchez-Partida, Richard D. W. Kelly, Kelly, Richard D. W., Sanchez-Partilda, L. Gabriel, O'Bryan, MK, Holland, Michael   +46 more
core   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source