Results 61 to 70 of about 461,287 (304)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Association of borderline hypertension defined by ACC-AHA diagnostic criteria during pregnancy with neurodevelopment in infants

BMC Medicine
Background The American College of Cardiology (ACC) and the American Heart Association (AHA) revised the diagnostic criteria for hypertension, recommending a lower threshold of 130/80 mmHg for nonpregnant adults.
Yuanyuan Zhang, Jiangbo Du, Xue You, Tianyu Sun, Hong Lv, Yangqian Jiang, Tao Jiang, Rui Qin, Xin Xu, Yuanyan Dou, Bo Xu, Guangfu Jin, Hongbing Shen, Zhibin Hu, Yuan Lin, Xiangqing Kong, Hongxia Ma   +16 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Parent-offspring correlations under full-sib and parent-offspring mating systems

, 1975
A study of the parent-offspring correlations under full-sib mating and parent-offspring mating system has been conducted. A general theory for obtaining the correlation between one parent and k offspring, as well as the correlation between both the ...
George, K. C., Narain, P.
core   +1 more source

Titanium exposure and gestational diabetes mellitus: associations and potential mediation by perturbation of amino acids in early pregnancy

Environmental Health
Background Several recent studies reported the potential adverse effects of titanium exposure on glucose homeostasis among the non-pregnant population, but the association of titanium exposure with gestational diabetes mellitus (GDM) is scarce.
Yangqian Jiang, Tianyu Sun, Yue Jiang, Xiaoyan Wang, Qi Xi, Yuanyan Dou, Hong Lv, Yuting Peng, Shuxin Xiao, Xin Xu, Cong Liu, Bo Xu, Xiumei Han, Hongxia Ma, Zhibin Hu, Zhonghua Shi, Jiangbo Du, Yuan Lin, China National Birth Cohort (CNBC) Study Group   +18 more
doaj   +1 more source

Relative costs of offspring sex and offspring survival in a polygynous mammal [PDF]

Biology Letters, 2016
Costs of reproduction are expected to be ubiquitous in wild animal populations and understanding the drivers of variation in these costs is an important aspect of life-history evolution theory. We use a 43 year dataset from a wild population of red deer to examine the relative importance of two factors that influence the costs of reproduction to ...
Froy, Hannah, Walling, Craig A, Pemberton, Josephine M, Clutton-Brock, Tim H, Kruuk, Loeske EB   +4 more
openaire   +4 more sources

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Associations of maternal dietary iron intake during pregnancy with infant neurodevelopment: evidence from a prospective cohort study

Nutrition Journal
Background Iron, an essential micronutrient, plays a critical role in fetal neurodevelopment. Animal studies have demonstrated that maternal iron-deficient diets during pregnancy induce permanent structural and functional alterations in offspring brains.
Rui Qin, Liya Pang, Haiting Hu, Yangqian Jiang, Hong Lv, Kan Ye, Cong Liu, Xin Xu, Xiaoyu Liu, Kun Zhou, Tao Jiang, Jiangbo Du, Lingmin Hu, Zhibin Hu, Zhonghua Shi, Yuan Lin   +15 more
doaj   +1 more source

Conflict over condition-dependent sex allocation can lead to mixed sex-determination systems [PDF]

, 2014
Theory suggests that genetic conflicts drive turnovers between sex-determining mechanisms, yet these studies only apply to cases where sex allocation is independent of environment or condition.
Kuijper, B, Pen, Ido, Pen, I, Kuijper, Bram   +3 more
core   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source